中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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CAS IR Grid
机构
上海药物研究所 [10]
金属研究所 [3]
大连化学物理研究所 [2]
寒区旱区环境与工程研... [1]
上海营养与健康研究所 [1]
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OAI收割 [16]
iSwitch采集 [1]
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期刊论文 [17]
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2023 [2]
2022 [2]
2021 [1]
2020 [2]
2019 [2]
2018 [1]
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Discovery of JN122, a Spiroindoline-Containing Molecule that Inhibits MDM2/p53 Protein-Protein Interaction and Exerts Robust In Vivo Antitumor Efficacy
期刊论文
OAI收割
JOURNAL OF MEDICINAL CHEMISTRY, 2023, 卷号: 66, 期号: 24, 页码: 16991-17025
作者:
Cheng, Jing
;
Yan, Ziqin
;
Jiang, Kailong
;
Liu, Chen
;
Xu, Dehua
  |  
收藏
  |  
浏览/下载:6/0
  |  
提交时间:2024/02/19
Discovery of PVD-06 as a Subtype-Selective and Efficient PTPN2 Degrader
期刊论文
OAI收割
JOURNAL OF MEDICINAL CHEMISTRY, 2023, 卷号: 66, 期号: 22, 页码: 15269-15287
作者:
Hu, Linghao
;
Li, Huiyun
;
Qin, Junlin
;
Yang, Dan
;
Liu, Jieming
  |  
收藏
  |  
浏览/下载:27/0
  |  
提交时间:2024/02/27
Structure-based rational design enables efficient discovery of a new selective and potent AKT PROTAC degrader
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2022, 卷号: 238, 页码: 15
作者:
Zhu, Cheng-Liang
;
Luo, Xiaomin
;
Tian, Tian
;
Rao, Zijian
;
Wang, Hanlin
  |  
收藏
  |  
浏览/下载:30/0
  |  
提交时间:2022/08/16
AKT
Protein kinase B
PROTAC
Chemical degrader
Rational design
Mechanisms of Grain Refinement in Direct-Chill Casting 2024 Aluminum Alloy With Intensive Melt Shearing
期刊论文
OAI收割
METALLURGICAL AND MATERIALS TRANSACTIONS A-PHYSICAL METALLURGY AND MATERIALS SCIENCE, 2022, 页码: 9
作者:
Liu, Xudong
;
Zhu, Qingfeng
;
Zhu, Cheng
;
Zuo, Yubo
;
Jiang, Haichang
  |  
收藏
  |  
浏览/下载:18/0
  |  
提交时间:2022/07/01
SARS-CoV-2 envelope protein causes acute respiratory distress syndrome (ARDS)-like pathological damages and constitutes an antiviral target
期刊论文
OAI收割
CELL RESEARCH, 2021, 页码: 14
作者:
Xia, Bingqing
;
Shen, Xurui
;
He, Yang
;
Pan, Xiaoyan
;
Liu, Feng-Liang
  |  
收藏
  |  
浏览/下载:75/0
  |  
提交时间:2021/08/17
Fatigue properties of titanium alloy custom short stems fabricated by electron beam melting
期刊论文
OAI收割
JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY, 2020, 卷号: 52, 页码: 180-188
作者:
Wang, Liao
;
Li, Shujun
;
Yan, Mengning
;
Cheng, Yubo
;
Hou, Wentao
  |  
收藏
  |  
浏览/下载:25/0
  |  
提交时间:2021/02/02
Custom short stem
Titanium alloy
Electron beam melting
Fatigue property
Fatigue properties of titanium alloy custom short stems fabricated by electron beam melting
期刊论文
OAI收割
JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY, 2020, 卷号: 52, 页码: 180-188
作者:
Wang, Liao
;
Li, Shujun
;
Yan, Mengning
;
Cheng, Yubo
;
Hou, Wentao
  |  
收藏
  |  
浏览/下载:28/0
  |  
提交时间:2021/02/02
Custom short stem
Titanium alloy
Electron beam melting
Fatigue property
fDiscovery of pyrazole-thiophene derivatives as highly Potent, orally active Akt inhibitors
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 180, 页码: 72-85
作者:
Zhan, Wenhu
;
Che, Jinxin
;
Xu, Lei
;
Wu, Yizhe
;
Hu, Xiaobei
  |  
收藏
  |  
浏览/下载:20/0
  |  
提交时间:2020/07/01
Pyrazole-thiophene derivatives
Akt inhibitor
Antitumor
Discovery of novel indoleaminopyrimidine NIK inhibitors based on molecular docking-based support vector regression (SVR) model
期刊论文
OAI收割
CHEMICAL PHYSICS LETTERS, 2019, 卷号: 718, 页码: 38-45
作者:
Ye, Qing
;
Li, Qiu
;
Gao, Anhui
;
Ying, Huazhou
;
Cheng, Gang
  |  
收藏
  |  
浏览/下载:10/0
  |  
提交时间:2020/07/01
Convenient preparation of pinometostat and related 5 '-deoxy-5 '-amino adenosine derivatives as well as their activity against DOT1L
期刊论文
OAI收割
TETRAHEDRON LETTERS, 2018, 卷号: 59, 期号: 4, 页码: 415-417
作者:
Liu, Tongchao
;
Ren, Huanming
;
Li, Cong
;
Chen, Guohua
;
Cheng, Maosheng
  |  
收藏
  |  
浏览/下载:27/0
  |  
提交时间:2019/01/08
DOTI L inhibitor
Pinometostat
Amination
5 '-Deoxy-5 '-amino adenosine derivative
Structure activity relationship