机构

• 上海药物研究所 [38]
• 青海盐湖研究所 [11]
• 上海硅酸盐研究所 [6]
• 合肥物质科学研究院 [5]

采集方式

• OAI收割 [60]

内容类型

• 期刊论文 [60]

发表日期

• 2026 [1]
• 2025 [12]
• 2024 [4]
• 2023 [1]
• 2022 [7]
• 2021 [9]
• 更多

学科主题

• Materials ... [1]
• Materials ... [1]
• Metallurgy... [1]

筛选

浏览/检索结果: 共60条，第1-10条 帮助 条数/页： 5101520253035404550556065707580859095100 排序方式： 请选择发表日期升序发表日期降序题名升序题名降序提交时间升序提交时间降序作者升序作者降序 Discovery and optimization of Menin-MLL inhibitors targeting acute myeloid leukemia 期刊论文  OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2026, 卷号: 307, 页码: 15 作者:  Xiao, Qitao;  Wang, Yuxian;  Shen, Zheyuan;  Mo, Jun;  Li, Cong   |  收藏  |  浏览/下载：0/0  |  提交时间：2026/04/01 MLL-R AML  Menin inhibitor  thieno[2  d ]pyrimidine  Machine learning   Rational engineering of degradation tail-driven CELMoD-antibody conjugates for precision malignancy therapy 期刊论文  OAI收割 ACTA PHARMACEUTICA SINICA B, 2025, 卷号: 15, 期号: 12, 页码: 6510-6528 作者:  Guo, Yu;  Song, Yi;  Wang, Hanlin;  Lu, Yang;  Zhang, Jingyu   |  收藏  |  浏览/下载：0/0  |  提交时间：2026/01/29 Degrader-antibody conjugate  Antibody-drug conjugate  Cereblon E3 ligase modulator  Immunomodulatory drug  Molecular glue  Targeted protein degradation  Multiple myeloma  Hematologic malignancy   Development of Dual FLT3 and CHK1 PROTACs for the Treatment of AML 期刊论文  OAI收割 JOURNAL OF MEDICINAL CHEMISTRY, 2025, 卷号: 68, 期号: 20, 页码: 21939-21961 作者:  Lian, Xuanmin;  Gao, Yue;  Du, Wenjing;  Xu, Chengcheng;  Dong, Xiaowu   |  收藏  |  浏览/下载：0/0  |  提交时间：2025/12/04 Modular PROTAC/IMiD Bifunctional Molecule Design for the Degradation of Synergistic Targets in the Treatment of Lymphoma 期刊论文  OAI收割 JOURNAL OF MEDICINAL CHEMISTRY, 2025, 卷号: 68, 期号: 20, 页码: 21249-21281 作者:  Jin, Yuheng;  Liao, Xueyan;  Zhang, Jingyu;  Duan, Haiting;  Xu, Ran   |  收藏  |  浏览/下载：0/0  |  提交时间：2025/12/04 Discovery of pyrrolo[2,3-d]pyrimidine derivatives as novel FLT3/ IRAK4 inhibitors 期刊论文  OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2025, 卷号: 296, 页码: 23 作者:     |  收藏  |  浏览/下载：26/0  |  提交时间：2025/08/20 AML  FLT3/IRAK4 inhibitor  Pyrrolo [2,3-d] pyrimidine  Acquired resistance  Adaptive resistance   Design, synthesis, and evaluation of Menin-targeting compounds for the treatment of acute Myelocytic leukemia (AML) 期刊论文  OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2025, 卷号: 296, 页码: 17 作者:  Mo, Jun;  Wang, Yuxian;  Pan, Youlu;  Xiao, Qitao;  Zhao, Jinyi   |  收藏  |  浏览/下载：37/0  |  提交时间：2025/08/20 Menin  High binding affinity  Anti-proliferation activity  AML   Discovery of a Selective and Potent BCL6 PROTAC with Efficacious Antiproliferative Activity for the Treatment of Diffuse Large B-Cell Lymphoma 期刊论文  OAI收割 JOURNAL OF MEDICINAL CHEMISTRY, 2025, 卷号: 68, 期号: 19, 页码: 20180-20206 作者:  Yu, Xiaoli;  Liao, Xueyan;  Zhang, Jingyu;  Wang, Hanlin;  Li, Xian   |  收藏  |  浏览/下载：0/0  |  提交时间：2025/12/04 Discovery of Piperazine-Amide Derivatives as Highly Potent and Selective RET Inhibitors 期刊论文  OAI收割 ACS MEDICINAL CHEMISTRY LETTERS, 2025, 页码: 8 作者:  Luo, Penghao   |  收藏  |  浏览/下载：0/0  |  提交时间：2025/12/04 RET  KDR  Selective Inhibitor  Piperazine-amide   Discovery of a ubiquitin-specific protease 10 inhibitor with high binding affinity promoting cell apoptosis via down-regulated CDK4 for the treatment of hepatocellular carcinoma 期刊论文  OAI收割 BIOORGANIC CHEMISTRY, 2025, 卷号: 163, 页码: 17 作者:  Lu, Yang;  Wang, Wentao;  Yuan, Cheng;  Luo, Mengxin;  Wang, Peipei   |  收藏  |  浏览/下载：0/0  |  提交时间：2025/12/04 HCC  USP10  Deubiquitination  Binding affinity  CDK4   Proteogenomic characterization of non-functional clinically relevant subgroups 期刊论文  OAI收割 CANCER CELL, 2025, 卷号: 43, 期号: 4, 页码: 36 作者:  Ji, Shunrong;  Cao, Lihua;  Gao, Jing;  Du, Yang;  Ye, Zeng   |  收藏  |  浏览/下载：59/0  |  提交时间：2025/06/23