中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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大连化学物理研究... [182]
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Development of 3-arylaminothiophenic-2-carboxylic acid derivatives as new FTO inhibitors showing potent antileukemia activities
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2025, 卷号: 289, 页码: 17
作者:
Zhang, Deyan
;
Liu, Lu
;
Li, Ming
;
Hu, Xinyi
;
Zhang, Xi
  |  
收藏
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浏览/下载:0/0
  |  
提交时间:2025/04/24
RNA modification
N 6-methyladenosine
Demethylase FTO
Structure-activity relationship
Antileukemia
Modular Synthesis of the Potent Antibiotic Amycolamicin and Diastereomeric Analogues Thereof
期刊论文
OAI收割
ORGANIC LETTERS, 2025, 卷号: 27, 期号: 14, 页码: 3631-3636
作者:
Yin, Xuejian
;
Zhang, Zhengxuan
;
Yuan, Ziqi
;
Zhu, Qiuyu
;
Xu, Peng
  |  
收藏
  |  
浏览/下载:0/0
  |  
提交时间:2025/05/27
A patenting perspective of fat mass and obesity associated protein (FTO) inhibitors: 2017-present
期刊论文
OAI收割
EXPERT OPINION ON THERAPEUTIC PATENTS, 2025, 页码: 10
作者:
Dong, Ze
;
Huang, Yue
;
Xia, Wenyang
;
Liao, Yonggang
;
Yang, Cai-Guang
  |  
收藏
  |  
浏览/下载:0/0
  |  
提交时间:2025/05/27
RNA methylation
FTO inhibitors
anticancer
patents
obesity
Oral FPR2/ALX modulators tune myeloid cell activity to ameliorate mucosal inflammation in inflammatory bowel disease
期刊论文
OAI收割
ACTA PHARMACOLOGICA SINICA, 2025, 页码: 16
作者:
Yang, Wen-sheng
;
Liu, Qing
;
Li, Yang
;
Li, Guan-yi
;
Lin, Shi
  |  
收藏
  |  
浏览/下载:0/0
  |  
提交时间:2025/04/24
IBD
FPR2/ALX
Quin-C1
Quin-C7
neutrophils
macrophages
An efficient deep learning-based strategy to screen inhibitors for GluN1/GluN3A receptor
期刊论文
OAI收割
ACTA PHARMACOLOGICA SINICA, 2025, 页码: 9
作者:
Wang, Ze-chen
;
Zeng, Yue
;
Sun, Jin-yuan
;
Chen, Xue-qin
;
Wu, Hao-chen
  |  
收藏
  |  
浏览/下载:0/0
  |  
提交时间:2025/04/24
deep learning
scoring function
GluN1/GluN3A receptor
N
-methyl-
D
-aspartate (NMDA) receptor
virtual screening
drug discovery
Discovery of Covalent and Cell-Active ALKBH5 Inhibitors with Potent Antileukemia Effects
In Vivo
期刊论文
OAI收割
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2025, 页码: 9
作者:
Wu, Hengbo
;
Lai, Gan-Qiang
;
Cheng, Ruixiang
;
Huang, Hui
;
Wang, Ju
  |  
收藏
  |  
浏览/下载:0/0
  |  
提交时间:2025/04/24
RNA epigenetics
N
(6)-methyladenosine
ALKBH5
covalent inhibitor
antileukemia
Terrestrial ecosystem response to Early Cretaceous global environmental change: A calibrated, high-resolution Aptian record from Northeast China
期刊论文
OAI收割
EARTH AND PLANETARY SCIENCE LETTERS, 2025, 卷号: 653, 页码: 13
作者:
Sun, Ming-Dao
;
Lin, Qin
;
Ramezani, Jahandar
;
Liu, Jiang-Si
;
Lu, Zheng-An
  |  
收藏
  |  
浏览/下载:19/0
  |  
提交时间:2025/04/03
Early Cretaceous
Aptian
CA-ID-TIMS geochronology
Astrochronology
Carbon isotope stratigraphy
Discovery of Novel RNA Demethylase FTO Inhibitors Featuring an Acylhydrazone Scaffold with Potent Antileukemia Activity
期刊论文
OAI收割
JOURNAL OF MEDICINAL CHEMISTRY, 2025, 页码: 22
作者:
Liang, Xuewu
;
Huang, Yue
;
Ren, Hairu
;
Liu, Qi
;
Chen, Liang
  |  
收藏
  |  
浏览/下载:12/0
  |  
提交时间:2025/04/01
Structure-Guided Development of ClpP Agonists with Potent Therapeutic Activities against Staphylococcus aureus Infection
期刊论文
OAI收割
JOURNAL OF MEDICINAL CHEMISTRY, 2025, 卷号: 68, 期号: 2, 页码: 1810-1823
作者:
Zhang, Tao
;
Wu, Wei
;
Zhao, Yanling
;
Ding, Ziang
;
Wei, Bingyan
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收藏
  |  
浏览/下载:10/0
  |  
提交时间:2025/04/01
Acoustic emission and microfracture analysis of strain rockbursts in deep granite under varying intermediate principal stresses
期刊论文
OAI收割
MEASUREMENT, 2025, 卷号: 242, 页码: 16
作者:
Guo, Guang-tao
;
Xu, Ding-Ping
;
Wu, Xiao-gang
;
Zhu, Jun-xing
;
Xu, Huai-sheng
  |  
收藏
  |  
浏览/下载:0/0
  |  
提交时间:2025/06/27
Strain rockburst
B -value
RA-AF
Fracture morphology
Fractal dimension