中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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CAS IR Grid
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上海药物研究所 [19]
沈阳应用生态研究所 [9]
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期刊论文 [74]
会议论文 [3]
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Discovery of pyrrolo[2,3-d]pyrimidine derivatives as novel FLT3/ IRAK4 inhibitors
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2025, 卷号: 296, 页码: 23
作者:
Yuan, Haibin
;
Gao, Yue
;
Wang, Peipei
;
Dong, Xiaowu
;
Li, Jia
  |  
收藏
  |  
浏览/下载:1/0
  |  
提交时间:2025/08/20
AML
FLT3/IRAK4 inhibitor
Pyrrolo [2,3-d] pyrimidine
Acquired resistance
Adaptive resistance
Design, synthesis, and evaluation of Menin-targeting compounds for the treatment of acute Myelocytic leukemia (AML)
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2025, 卷号: 296, 页码: 17
作者:
Mo, Jun
;
Wang, Yuxian
;
Pan, Youlu
;
Xiao, Qitao
;
Zhao, Jinyi
  |  
收藏
  |  
浏览/下载:4/0
  |  
提交时间:2025/08/20
Menin
High binding affinity
Anti-proliferation activity
AML
Rice leaves microstructure-inspired high-efficiency electrodes for green hydrogen production
期刊论文
OAI收割
NANOSCALE, 2025, 卷号: 17, 期号: 10, 页码: 5812-5822
作者:
Li, Yuliang
;
Gao, Jinxin
;
Wang, Zhaoyang
  |  
收藏
  |  
浏览/下载:25/0
  |  
提交时间:2025/03/21
Development of novel epoxyketone macrocyclic peptidyl proteasome inhibitors through OPA-mediated one-step cyclization of unprotected peptides
期刊论文
OAI收割
BIOORGANIC CHEMISTRY, 2025, 卷号: 156, 页码: 16
作者:
Zeng, Gongruixue
;
Xu, Gaoya
;
Gao, Lixin
;
Zheng, Xiaoli
;
Chi, Xinglong
  |  
收藏
  |  
浏览/下载:33/0
  |  
提交时间:2025/04/01
Proteasome inhibitors
Macrocycle
Stability
Anti-cancer activities
Discovery of a potential hematologic malignancies therapy: Selective and potent HDAC7 PROTAC degrader targeting non-enzymatic function
期刊论文
OAI收割
ACTA PHARMACEUTICA SINICA B, 2025, 卷号: 15, 期号: 3, 页码: 1659-1679
作者:
Jin, Yuheng
;
Qi, Xuxin
;
Yu, Xiaoli
;
Cheng, Xirui
;
Chen, Boya
  |  
收藏
  |  
浏览/下载:19/0
  |  
提交时间:2025/06/23
HDAC7
PROTAC
Selectivity
Hematologic malignancies
Non-enzymatic function
Defining ortholog-specific UHRF1 inhibition by STELLA for cancer therapy
期刊论文
OAI收割
NATURE COMMUNICATIONS, 2025, 卷号: 16, 期号: 1, 页码: 22
作者:
Bai, Wenjing
;
Xu, Jinxin
;
Gu, Wenbin
;
Wang, Danyang
;
Cui, Ying
  |  
收藏
  |  
浏览/下载:42/0
  |  
提交时间:2025/04/01
Auto-RapTAC: A Versatile and Sustainable Platform for the Automated Rapid Synthesis and Evaluation of PROTAC
期刊论文
OAI收割
JOURNAL OF MEDICINAL CHEMISTRY, 2025, 页码: 15
作者:
Chen, Jiexuan
;
Wu, Mingfei
;
Mo, Jun
;
Hong, Ju
;
Wang, Wei
  |  
收藏
  |  
浏览/下载:31/0
  |  
提交时间:2025/04/01
Exploration of novel 20S proteasome activators featuring anthraquinone structures and their application in hypoxic cardiomyocyte protection
期刊论文
OAI收割
BIOORGANIC & MEDICINAL CHEMISTRY, 2024, 卷号: 115, 页码: 10
作者:
Yu, Qian
;
Gao, Lixin
;
Xu, Linhao
;
Han, Yubing
;
Cao, Yu
  |  
收藏
  |  
浏览/下载:37/0
  |  
提交时间:2024/12/11
Analysis of near-well hydraulic fracture propagation behavior in inhomogeneous deep-sea hydrate-bearing-sediments
期刊论文
OAI收割
GEOENERGY SCIENCE AND ENGINEERING, 2024, 卷号: 242, 页码: 15
作者:
Liu, Jinxin
;
Yu, Yongping
;
Ma, Xiaolong
;
Sun, Youhong
;
Li, Bing
  |  
收藏
  |  
浏览/下载:9/0
  |  
提交时间:2025/06/27
Inhomogeneous hydrate reservoir
Disseminated hydrates
Extended finite element method
Hydraulic fracturing
Insight into nonlinear thermal consolidation of saturated clay under coupled thermo-mechanical loading: a unified one-dimensional model
期刊论文
OAI收割
ACTA GEOTECHNICA, 2024, 页码: 27
作者:
Lu, Mengmeng
;
Sun, Jinxin
;
Wen, Minjie
;
Yang, Kang
;
Li, Kuo
  |  
收藏
  |  
浏览/下载:13/0
  |  
提交时间:2025/06/27
Heat transfer
Nonlinear consolidation
Saturated clay
Temperature effect
Thermo-hydro-mechanical coupling effect
Thermo-osmosis