机构

• 上海硅酸盐研究所 [36]
• 上海药物研究所 [15]
• 地质与地球物理研究... [13]
• 地理科学与资源研究所 [4]
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• OAI收割 [85]
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内容类型

• 期刊论文 [86]

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• 2025 [3]
• 2024 [5]
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筛选

浏览/检索结果: 共86条，第1-10条 帮助 条数/页： 5101520253035404550556065707580859095100 排序方式： 请选择题名升序题名降序发表日期升序发表日期降序提交时间升序提交时间降序作者升序作者降序 A Rationally Designed Sulfonium Lipoglycopeptide with Micelles Self-Assembly to Combat Multidrug Resistance via Dual Enhanced Cell Wall-Membrane Inhibition and T7SS Proteins Downregulation 期刊论文  OAI收割 JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2025, 卷号: 147, 期号: 15, 页码: 12587-12603 作者:  Xie, Yuanyuan;  Wang, Xiaowen;  Li, Fang;  Chen, Zhifu;  Li, Qun   |  收藏  |  浏览/下载：2/0  |  提交时间：2025/05/27 A natural small molecule isoginkgetin alleviates hypercholesterolemia and atherosclerosis by targeting ACLY 期刊论文  OAI收割 THERANOSTICS, 2025, 卷号: 15, 期号: 10, 页码: 4325-4344 作者:  Zhang, Zhidan;  Chen, Meijie;  Xu, Yitong;  Wang, Zhihua;  Liu, Zhenghong   |  收藏  |  浏览/下载：1/0  |  提交时间：2025/06/23 Atherosclerosis  Hyperlipidemia  ATP-Citrate lyase (ACLY)  lipid metabolism  Isoginkgetin   A Phase I Study to Evaluate the Safety, Tolerability, Pharmacokinetics of BGT-002, a Novel ATP-Citrate Lyase Inhibitor, in Healthy Chinese Subjects 期刊论文  OAI收割 DRUG DESIGN DEVELOPMENT AND THERAPY, 2025, 卷号: 19, 页码: 1783-1794 作者:  Liu, Yun;  Yu, Chengyin;  Zhang, Yifan;  Xie, Zhifu;  Wang, Yating   |  收藏  |  浏览/下载：3/0  |  提交时间：2025/04/24 safety  tolerability  pharmacokinetics  pharmacodynamics  BGT-002  novel ACLY inhibitor   Single Amine or Guanidine Modification on Norvancomycin and Vancomycin to Overcome Multidrug-Resistance through Augmented Lipid II Binding and Increased Membrane Activity 期刊论文  OAI收割 JOURNAL OF MEDICINAL CHEMISTRY, 2024, 卷号: 67, 期号: 22, 页码: 20639-20663 作者:  Bian, Xiaolei;  Chen, Zhifu;  Li, Fang;  Xie, Yuanyuan;  Li, Yi   |  收藏  |  浏览/下载：13/0  |  提交时间：2024/12/11 Discovery of Alkyl Conjugated Diene Diacids as Novel ACLY Inhibitors 期刊论文  OAI收割 CHINESE JOURNAL OF ORGANIC CHEMISTRY, 2024, 卷号: 44, 期号: 11, 页码: 3476-3489 作者:  Cheng, Tingting;  Song, Gaolei;  Cheng, Long;  Wang, Fan;  Sun, Xinyu   |  收藏  |  浏览/下载：11/0  |  提交时间：2025/02/28 metabolic diseases  ATP-citrate lyase (ACLY)  lipogenesis  ACLY inhibitors  dienyldicarboxylic acid   Potential therapeutic strategies for MASH: from preclinical to clinical development 期刊论文  OAI收割 LIFE METABOLISM, 2024, 卷号: 3, 期号: 5, 页码: loae029 作者:  Xie, Zhifu;  Li, Yufeng;  Cheng, Long;  Huang, Yidan;  Rao, Wanglin   |  收藏  |  浏览/下载：1/0  |  提交时间：2025/06/04 steatosis  inflammation  fibrosis  metabolic dysfunction-associated steatohepatitis  pharmacotherapy   Simultaneous determination of BGT-002 and its acyl glucuronide metabolite ZM326E-M2 in human plasma by liquid chromatography-tandem mass spectrometry and its application to a pharmacokinetic study 期刊论文  OAI收割 JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2024, 卷号: 243, 页码: 8 作者:  Zhu, Xueran;  Cui, Shumin;  Liu, Xinjing;  Zhang, Mei;  Xie, Zhifu   |  收藏  |  浏览/下载：16/0  |  提交时间：2024/05/31 ATP-Citrate Lyase  BGT-002  Acyl glucuronide metabolite  Pseudo-MRM  LC-MS/MS  Pharmacokinetics   AMPK phosphorylation of FNIP1 (S220) controls mitochondrial function and muscle fuel utilization during exercise 期刊论文  OAI收割 SCIENCE ADVANCES, 2024, 卷号: 10, 期号: 6, 页码: 15 作者:  Xiao, Liwei;  Yin, Yujing;  Sun, Zongchao;  Liu, Jing;  Jia, Yuhuan   |  收藏  |  浏览/下载：24/0  |  提交时间：2024/05/31 Fast Radio Bursts: Electromagnetic Counterparts to Extreme Mass-ratio Inspirals 期刊论文  OAI收割 ASTROPHYSICAL JOURNAL LETTERS, 2023, 卷号: 956, 期号: 1, 页码: L2 作者:  Li, Rui-Nan;  Zhao, Zhen-Yin;  Gao, Zhifu;  Wang, Fa-Yin   |  收藏  |  浏览/下载：0/0  |  提交时间：2024/01/10 HIF-1 alpha inhibition in macrophages preserves acute liver failure by reducing IL-1 beta production 期刊论文  OAI收割 FASEB JOURNAL, 2023, 卷号: 37, 期号: 9, 页码: 12 作者:  Kong, Xiangrong;  Liu, Wei;  Zhang, Xinwen;  Zhou, Chendong;  Sun, Xinyu   |  收藏  |  浏览/下载：29/0  |  提交时间：2023/10/17 acute liver failure  cell death  HIF-1 alpha inhibitor  interleukin-1 beta  macrophage