中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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CAS IR Grid
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金属研究所 [27]
上海药物研究所 [20]
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Development of novel epoxyketone macrocyclic peptidyl proteasome inhibitors through OPA-mediated one-step cyclization of unprotected peptides
期刊论文
OAI收割
BIOORGANIC CHEMISTRY, 2025, 卷号: 156, 页码: 16
作者:
Zeng, Gongruixue
;
Xu, Gaoya
;
Gao, Lixin
;
Zheng, Xiaoli
;
Chi, Xinglong
  |  
收藏
  |  
浏览/下载:9/0
  |  
提交时间:2025/04/01
Proteasome inhibitors
Macrocycle
Stability
Anti-cancer activities
Auto-RapTAC: A Versatile and Sustainable Platform for the Automated Rapid Synthesis and Evaluation of PROTAC
期刊论文
OAI收割
JOURNAL OF MEDICINAL CHEMISTRY, 2025, 页码: 15
作者:
Chen, Jiexuan
;
Wu, Mingfei
;
Mo, Jun
;
Hong, Ju
;
Wang, Wei
  |  
收藏
  |  
浏览/下载:13/0
  |  
提交时间:2025/04/01
Exploration of novel 20S proteasome activators featuring anthraquinone structures and their application in hypoxic cardiomyocyte protection
期刊论文
OAI收割
BIOORGANIC & MEDICINAL CHEMISTRY, 2024, 卷号: 115, 页码: 10
作者:
Yu, Qian
;
Gao, Lixin
;
Xu, Linhao
;
Han, Yubing
;
Cao, Yu
  |  
收藏
  |  
浏览/下载:9/0
  |  
提交时间:2024/12/11
Single-cell sequencing reveals the heterogeneity of pancreatic neuroendocrine tumors under genomic instability and histological grading
期刊论文
OAI收割
ISCIENCE, 2024, 卷号: 27, 期号: 9, 页码: 18
作者:
Ye, Zeng
;
Zhou, Yan
;
Hu, Yuheng
;
Li, Qiang
;
Xu, Zijin
  |  
收藏
  |  
浏览/下载:11/0
  |  
提交时间:2024/11/05
tumor cells
CNV neutral tumor cells
neuroendocrine cells
profile
Discovery of a Highly Potent and Selective BRD9 PROTAC Degrader Based on E3 Binder Investigation for the Treatment of Hematological Tumors
期刊论文
OAI收割
JOURNAL OF MEDICINAL CHEMISTRY, 2024, 页码: 28
作者:
Duan, Haiting
;
Zhang, Jingyu
;
Gui, Renzhao
;
Lu, Yang
;
Pang, Ao
  |  
收藏
  |  
浏览/下载:7/0
  |  
提交时间:2024/08/20
Discovery of potent small molecule ubiquitin-specific protease 10 inhibitors with anti-hepatocellular carcinoma activity through regulating YAP expression
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2024, 卷号: 272, 页码: 21
作者:
Lu, Yang
;
Gao, Jian
;
Wang, Peipei
;
Chen, Haifeng
;
He, Xinjun
  |  
收藏
  |  
浏览/下载:6/0
  |  
提交时间:2024/07/12
Hepatocellular carcinoma
Ubiquitin-specific protease 10
Deubiquitination
Selectivity
Extinction of microgravity partially premixed flame aboard the Chinese Space Station
期刊论文
OAI收割
PROCEEDINGS OF THE COMBUSTION INSTITUTE, 2024, 卷号: 40, 期号: 1-4, 页码: 7
作者:
Wen, Yuzhe
;
Li, Longfei
;
Li, Xingxian
;
Luo, Lei
;
Chen, Tao
  |  
收藏
  |  
浏览/下载:5/0
  |  
提交时间:2024/08/23
Partially premixed flame
Non-premixed flame
Radiation
Microgravity
Extinction
Structure-based identification of new orally bioavailable BRD9-PROTACs for treating acute myelocytic leukemia
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2023, 卷号: 262, 页码: 18
作者:
Zhang, Jingyu
;
Duan, Haiting
;
Gui, Renzhao
;
Wu, Mingfei
;
Shen, Liteng
  |  
收藏
  |  
浏览/下载:132/0
  |  
提交时间:2023/12/19
Acute myeloid leukemia
Bromodomain-containing protein 9
Proteolysis-targeting chimera
Orally bioavailable
Docking
Effects of quenching temperature on the microstructure and impact toughness of 50CrMnSiVNb spring steel
期刊论文
OAI收割
MATERIALS SCIENCE AND ENGINEERING A-STRUCTURAL MATERIALS PROPERTIES MICROSTRUCTURE AND PROCESSING, 2023, 卷号: 870, 页码: 14
作者:
Xia, Bo
;
Zhang, Peng
;
Wang, Bin
;
Li, Xiaowu
;
Zhang, Zhefeng
  |  
收藏
  |  
浏览/下载:1/0
  |  
提交时间:2024/01/07
Impact toughness
Quenching temperature
Carbides
Nucleation rate
A one-component phosphonium borane Lewis pair serves as a dual initiator and catalyst in the ring-opening alternating copolymerization of anhydrides and epoxides
期刊论文
OAI收割
POLYMER CHEMISTRY, 2022, 卷号: 13, 期号: 47, 页码: 6551-6563
作者:
Hui, Jiwen
;
Wang, Xiaowu
;
Yao, Xiaoqian
;
Li, Zhibo
  |  
收藏
  |  
浏览/下载:25/0
  |  
提交时间:2023/02/24