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Chinese Academy of Sciences Institutional Repositories Grid
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CAS IR Grid
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上海药物研究所 [353]
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Inhibited peroxidase activity of peroxiredoxin 1 by palmitic acid exacerbates nonalcoholic steatohepatitis in male mice
期刊论文
OAI收割
NATURE COMMUNICATIONS, 2025, 卷号: 16, 期号: 1, 页码: 19
作者:
Yin, Wen
;
Xu, Heng
;
Bai, Zhonghao
;
Wu, Yue
;
Zhang, Yan
  |  
收藏
  |  
浏览/下载:20/0
  |  
提交时间:2025/04/01
Combination of miR159 Mimics and Irinotecan Utilizing Lipid Nanoparticles for Enhanced Treatment of Colorectal Cancer
期刊论文
OAI收割
PHARMACEUTICS, 2024, 卷号: 16, 期号: 4, 页码: 18
作者:
Yang, Rulei
;
Liu, Yiran
;
Yang, Ning
;
Zhang, Tian
;
Hou, Jiazhen
  |  
收藏
  |  
浏览/下载:23/0
  |  
提交时间:2024/05/31
colorectal cancer
plant-derived miR159
irinotecan
lipid nanoparticle
Computing the relative binding affinity of ligands based on a pairwise binding comparison network
期刊论文
OAI收割
Nature computational science, 2023, 卷号: 3, 期号: 10, 页码: 860-872
作者:
Yu, Jie
;
Li, Zhaojun
;
Chen, Geng
;
Kong, Xiangtai
;
Hu, Jie
  |  
收藏
  |  
浏览/下载:29/0
  |  
提交时间:2024/03/26
αExtractor: a system for automatic extraction of chemical information from biomedical literature
期刊论文
OAI收割
SCIENCE CHINA-LIFE SCIENCES, 2023, 页码: 4
作者:
Xiong, Jiacheng
;
Liu, Xiaohong
;
Li, Zhaojun
;
Xiao, Hongzhong
;
Wang, Guangchao
  |  
收藏
  |  
浏览/下载:41/0
  |  
提交时间:2023/12/08
Bioactive compounds from Huashi Baidu decoction possess both antiviral and anti-inflammatory effects against COVID-19
期刊论文
OAI收割
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2023, 卷号: 120, 期号: 18, 页码: 11
作者:
Xu, Haiyu
;
Li, Shufen
;
Liu, Jiayuan
;
Cheng, Jinlong
;
Kang, Liping
  |  
收藏
  |  
浏览/下载:116/0
  |  
提交时间:2023/10/17
COVID-19
traditional Chinese medicine
TCMT-NDRD
antivirus
anti-inflammation
MolFilterGAN: a progressively augmented generative adversarial network for triaging AI-designed molecules
期刊论文
OAI收割
JOURNAL OF CHEMINFORMATICS, 2023, 卷号: 15, 期号: 1, 页码: 42
作者:
Liu, Xiaohong
;
Zhang, Wei
;
Tong, Xiaochu
;
Zhong, Feisheng
;
Li, Zhaojun
  |  
收藏
  |  
浏览/下载:28/0
  |  
提交时间:2024/03/27
De novo molecule design
Generative models
Deep learning
Virtual screening
Compound quality control
Design, Synthesis, and Biological Evaluation of Bipyridazine Derivatives as Stimulator of Interferon Genes (STING) Receptor Agonists
期刊论文
OAI收割
JOURNAL OF MEDICINAL CHEMISTRY, 2023, 卷号: 66, 期号: 5, 页码: 3327-3347
作者:
Shan, Bin
;
Hou, Hui
;
Zhang, Keke
;
Li, Rui
;
Shen, Chang
  |  
收藏
  |  
浏览/下载:31/0
  |  
提交时间:2024/03/27
Design, synthesis of novel benzimidazole derivatives as ENL inhibitors suppressing leukemia cells viability via downregulating the expression of MYC
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2023, 卷号: 248, 页码: 14
作者:
Guo, Siqi
;
Jia, Tongguan
;
Xu, Xiaoming
;
Yang, Feng
;
Xiao, Senhao
  |  
收藏
  |  
浏览/下载:37/0
  |  
提交时间:2023/04/10
ENL Inhibitor
YEATS domain
Histone lysine acetylation
Benzimidazole derivatives
Acute myeloid leukemia
Insights into divalent cation regulation and G(13)-coupling of orphan receptor GPR35
期刊论文
OAI收割
CELL DISCOVERY, 2022, 卷号: 8, 期号: 1, 页码: 12
作者:
Duan, Jia
;
Liu, Qiufeng
;
Yuan, Qingning
;
Ji, Yujie
;
Zhu, Shengnan
  |  
收藏
  |  
浏览/下载:27/0
  |  
提交时间:2023/04/10
In vitro and in vivo evaluation of the main protease inhibitor FB2001 against SARS-CoV-2
期刊论文
OAI收割
ANTIVIRAL RESEARCH, 2022, 卷号: 208, 页码: 10
作者:
Shang, Weijuan
;
Dai, Wenhao
;
Yao, Cheng
;
Xu, Ling
;
Tao, Xiangming
  |  
收藏
  |  
浏览/下载:34/0
  |  
提交时间:2023/04/10
SARS-CoV-2
SARS-CoV-2 variants
FB2001
Main protease
PBPK
Anti-SARS-CoV-2 in vivo