中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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CAS IR Grid
机构
合肥物质科学研究院 [9]
上海药物研究所 [8]
生态环境研究中心 [4]
数学与系统科学研究院 [3]
化学研究所 [2]
物理研究所 [1]
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期刊论文 [35]
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2025 [2]
2024 [2]
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纳米科技与材料物理:... [2]
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Preparation and characterization of LGR5 LOOP region-specific nanobodies
期刊论文
OAI收割
PROTEIN EXPRESSION AND PURIFICATION, 2025, 卷号: 229, 页码: 7
作者:
Jia, Li
;
Qiao, Huarui
;
Ding, Yuting
;
Cui, Qianqian
;
Wang, Yingjun
  |  
收藏
  |  
浏览/下载:25/0
  |  
提交时间:2025/04/01
LGR5
Nanobody
Wnt signaling
Topflash
Design, synthesis and pharmacological evaluation of 1,2,3,4-tetrahydrobenzofuro[2,3-c] pyridine derivatives as p21-activated kinase 4 inhibitors for treatment of pancreatic cancer
期刊论文
OAI收割
ACTA PHARMACEUTICA SINICA B, 2025, 卷号: 15, 期号: 1, 页码: 438-466
作者:
Li, Yang
;
Fang, Yan
;
Chen, Xiaoyu
;
Tong, Linjiang
;
Feng, Fang
  |  
收藏
  |  
浏览/下载:10/0
  |  
提交时间:2025/04/01
P21-activated kinase 4
Tetrahydrobenzofuro[2
3-c]pyridine
Structure-activity relationship
Allosteric inhibitor
Pharmacokinetics properties
Kinase selectivity
Pancreatic cancer
Immune infiltration
Zosuquidar Promotes Antitumor Immunity by Inducing Autophagic Degradation of PD-L1
期刊论文
OAI收割
ADVANCED SCIENCE, 2024
作者:
Ding, Ling
;
Guo, Hongjie
;
Zhang, Jie
;
Zheng, Mingming
;
Zhang, Wenjie
  |  
收藏
  |  
浏览/下载:3/0
  |  
提交时间:2024/11/20
ABCB1
autophagy
ER retention
PD-L1
zosuquidar
Discovery of a Covalent Inhibitor That Overcame Resistance to Venetoclax in AML Cells Overexpressing BFL-1
期刊论文
OAI收割
JOURNAL OF MEDICINAL CHEMISTRY, 2024, 页码: 36
作者:
Lou, Jianfeng
;
Zhou, Qianqian
;
Lyu, Xilin
;
Cen, Xinyi
;
Liu, Chen
  |  
收藏
  |  
浏览/下载:5/0
  |  
提交时间:2024/08/22
Design and synthesis of 1H-pyrazolo[3,4-
d
]pyrimidine derivatives as hematopoietic progenitor kinase 1 (HPK1) inhibitors
期刊论文
OAI收割
BIOORGANIC CHEMISTRY, 2023, 卷号: 140, 页码: 18
作者:
Zhang, Junjie
;
Li, Yan
;
Tang, Haotian
;
Zhou, Qianqian
;
Tong, Linjiang
  |  
收藏
  |  
浏览/下载:21/0
  |  
提交时间:2023/12/08
Cancer immunotherapy
HPK1
Structure -based design
HPK1 inhibitor
Development of HSP90 inhibitors-SN38 conjugates for cancer treatment
期刊论文
OAI收割
BIOORGANIC CHEMISTRY, 2023, 卷号: 137, 页码: 11
作者:
Cao, Yuting
;
Shen, Qianqian
;
Ding, Mengyuan
;
Chen, Yi
;
Lu, Wei
  |  
收藏
  |  
浏览/下载:75/0
  |  
提交时间:2023/10/17
HSP90
SN38 conjugate
Drug accumulation
Cancer treatment
Synthesis, and biological evaluation of EGFR/HER2-NAMPT conjugates for tumor treatment
期刊论文
OAI收割
MOLECULAR DIVERSITY, 2023, 页码: 20
作者:
Ding, Mengyuan
;
Shen, Qianqian
;
Lu, Wei
;
Zhu, Shulei
  |  
收藏
  |  
浏览/下载:100/0
  |  
提交时间:2023/10/17
EGFR
HER2
NAMPT
Resistance
Selectivity
Molecular docking
Error analysis of a conservative finite element scheme for time-dependent inductionless MHD problem
期刊论文
OAI收割
JOURNAL OF COMPUTATIONAL AND APPLIED MATHEMATICS, 2023, 卷号: 419, 页码: 22
作者:
Long, Xiaonian
;
Ding, Qianqian
;
Mao, Shipeng
  |  
收藏
  |  
浏览/下载:26/0
  |  
提交时间:2023/02/07
Inductionless magnetohydrodynamics
Current density conservation
Euler semi-implicit
Error estimate
Mixed finite element method
Pharmaceutical liposomal delivery-specific considerations of innovation and challenges
期刊论文
OAI收割
BIOMATERIALS SCIENCE, 2022, 页码: 14
作者:
Peng, Taoxing
;
Xu, Weihua
;
Li, Qianqian
;
Ding, Yang
;
Huang, Yongzhuo
  |  
收藏
  |  
浏览/下载:16/0
  |  
提交时间:2023/04/10
Error estimates of H(div)-conforming method for nonstationary magnetohydrodynamic system
期刊论文
OAI收割
ADVANCES IN COMPUTATIONAL MATHEMATICS, 2022, 卷号: 48, 期号: 5, 页码: 23
作者:
Ding, Qianqian
;
Mao, Shipeng
;
Sun, Jiaao
  |  
收藏
  |  
浏览/下载:17/0
  |  
提交时间:2023/02/07
Magnetohydrodynamics
Finite element method
H(div)-conforming element
Error analysis
Pressure-robust