机构

• 上海药物研究所 [12]
• 过程工程研究所 [1]

采集方式

• OAI收割 [13]

内容类型

• 期刊论文 [13]

发表日期

• 2024 [2]
• 2023 [3]
• 2022 [3]
• 2021 [2]
• 2020 [2]
• 2019 [1]
• 更多

学科主题

筛选

浏览/检索结果: 共13条，第1-10条 帮助 条数/页： 5101520253035404550556065707580859095100 排序方式： 请选择提交时间升序提交时间降序发表日期升序发表日期降序题名升序题名降序作者升序作者降序 Structure-based optimization of indoline-containing compounds as second generation inhibitors of NF-KB-inducing kinase (NIK) 期刊论文  OAI收割 JOURNAL OF MOLECULAR STRUCTURE, 2024, 卷号: 1295, 页码: 19 作者:  Cheng, Jing;  Yan, Ziqin;  Li, Xinzhi;  Liu, Chen;  Tong, Linjiang   |  收藏  |  浏览/下载：8/0  |  提交时间：2023/12/08 Kinase inhibitor  NIK  NF-KB2  Indoline  COT  Cytotoxicity   Discovery and Optimization of WDR5 Inhibitors via Cascade Deoxyribonucleic Acid-Encoded Library Selection Approach 期刊论文  OAI收割 JOURNAL OF MEDICINAL CHEMISTRY, 2024, 卷号: 67, 期号: 2, 页码: 1079-1092 作者:  Qin, Shaozhao;  Feng, Lijian;  Zhao, Qingyi;  Yan, Ziqin;  Lyu, Xilin   |  收藏  |  浏览/下载：17/0  |  提交时间：2024/02/27 Discovery of JN122, a Spiroindoline-Containing Molecule that Inhibits MDM2/p53 Protein-Protein Interaction and Exerts Robust In Vivo Antitumor Efficacy 期刊论文  OAI收割 JOURNAL OF MEDICINAL CHEMISTRY, 2023, 卷号: 66, 期号: 24, 页码: 16991-17025 作者:  Cheng, Jing;  Yan, Ziqin;  Jiang, Kailong;  Liu, Chen;  Xu, Dehua   |  收藏  |  浏览/下载：5/0  |  提交时间：2024/02/19 Selective degradation of cellular BRD3 and BRD4-L promoted by PROTAC molecules in six cancer cell lines 期刊论文  OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2023, 卷号: 254, 页码: 17 作者:  Yan, Ziqin;  Lyu, Xilin;  Lin, Dongze;  Wu, Gaoxing;  Gong, Yang   |  收藏  |  浏览/下载：25/0  |  提交时间：2023/10/17 Synthesis and Biological Evaluation of Sclareolide-Indole Conjugates and Their Derivatives 期刊论文  OAI收割 MOLECULES, 2023, 卷号: 28, 期号: 4, 页码: 1737 作者:  Cheng, Ying;  Lyu, Xilin;  Liu, Chen;  Wang, Xiancheng;  Cheng, Jing   |  收藏  |  浏览/下载：3/0  |  提交时间：2024/03/27 sclareolide  indole  polyphenol  acetal  antitumor activity   Mechano-bioconjugation Strategy Empowering Fusion Protein Therapeutics with Aggregation Resistance, Prolonged Circulation, and Enhanced Antitumor Efficacy 期刊论文  OAI收割 JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2022, 页码: 10 作者:  Liu, Yajie;  Bai, Xilin;  Lyu, Chengliang;  Fang, Jing;  Zhang, Fan   |  收藏  |  浏览/下载：13/0  |  提交时间：2023/02/24 Discovery of a selective and covalent small-molecule inhibitor of BFL-1 protein that induces robust apoptosis in cancer cells 期刊论文  OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2022, 卷号: 236, 页码: 114327 作者:  Feng, Xuexin;  Yan, Ziqin;  Zhou, Feilong;  Lou, Jianfeng;  Lyu, Xilin   |  收藏  |  浏览/下载：15/0  |  提交时间：2024/03/21 BFL-1  Apoptosis  Covalent inhibitor  Cytochrome c  BCL-2  Protein-Protein interaction   Structure-Based Discovery of MDM2/4 Dual Inhibitors that Exert Antitumor Activities against MDM4-Overexpressing Cancer Cells 期刊论文  OAI收割 JOURNAL OF MEDICINAL CHEMISTRY, 2022, 卷号: 65, 期号: 8, 页码: 6207-6230 作者:  Zhang, Shiyan;  Yan, Ziqin;  Li, Yafang;  Gong, Yang;  Lyu, Xilin   |  收藏  |  浏览/下载：21/0  |  提交时间：2022/08/16 Synthesis and bioactivity studies of covalent inhibitors derived from (-)-Chaetominine 期刊论文  OAI收割 JOURNAL OF MOLECULAR STRUCTURE, 2021, 卷号: 1241, 页码: 14 作者:  Zhou, Xian;  Feng, Xuexin;  Wang, Dachi;  Chen, Deheng;  Wu, Gaoxing   |  收藏  |  浏览/下载：88/0  |  提交时间：2021/08/17 Chaetominine  Cellular growth inhibition  Cancer cell line  Covalent warhead   Recent Progress and Clinical Development of Inhibitors that Block MDM4/p53 Protein-Protein Interactions 期刊论文  OAI收割 JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 64, 期号: 15, 页码: 10621-10640 作者:  Zhang, Shiyan;  Lou, Jianfeng;  Li, Yafang;  Zhou, Feilong;  Yan, Ziqin   |  收藏  |  浏览/下载：25/0  |  提交时间：2021/11/04