中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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CAS IR Grid
机构
上海药物研究所 [5]
采集方式
OAI收割 [5]
内容类型
期刊论文 [5]
发表日期
2024 [1]
2023 [1]
2022 [1]
2014 [1]
2013 [1]
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Proteasome activation: A novel strategy for targeting undruggable intrinsically disordered proteins
期刊论文
OAI收割
BIOORGANIC CHEMISTRY, 2024, 卷号: 145, 页码: 17
作者:
Yu, Qian
;
Wang, Zheng
;
Tu, Yutong
;
Cao, Yu
;
Zhu, Huajian
  |  
收藏
  |  
浏览/下载:0/0
  |  
提交时间:2024/05/07
20S proteasome
Proteasome activation
IDPs
Undruggable
Protein homeostasis
Exploration of novel four-membered-heterocycle constructed peptidyl proteasome inhibitors with improved metabolic stability for cancer treatment
期刊论文
OAI收割
BIOORGANIC CHEMISTRY, 2023, 卷号: 138, 页码: 22
作者:
Wang, Hanlin
;
Wu, Zhaoxiao
;
Cao, Yu
;
Gao, Lixin
;
Shao, Jiaan
  |  
收藏
  |  
浏览/下载:13/0
  |  
提交时间:2023/10/17
Metabolic stability
Four-membered heterocycles
Proteasome inhibitors
Multiple myeloma
Metabolism guided optimization of peptidomimetics as non-covalent proteasome inhibitors for cancer treatment
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2022, 卷号: 233, 页码: 18
作者:
Cao, Yu
;
Tu, Yutong
;
Fu, Liping
;
Yu, Qian
;
Gao, Lixin
  |  
收藏
  |  
浏览/下载:27/0
  |  
提交时间:2022/06/15
Metabolism
Design
Proteasome inhibitors
Non-covalent
Multiple myeloma
A Chemical Tuned Strategy to Develop Novel Irreversible EGFR-TK Inhibitors with Improved Safety and Pharmacokinetic Profiles
期刊论文
OAI收割
JOURNAL OF MEDICINAL CHEMISTRY, 2014, 卷号: 57, 期号: 23, 页码: 9889-9900
作者:
Xia, Guangxin
;
Chen, Wenteng
;
Zhang, Jing
;
Shao, Jiaan
;
Zhang, Yong
  |  
收藏
  |  
浏览/下载:31/0
  |  
提交时间:2019/01/08
Design, Synthesis, and Biological Evaluation of Novel Conformationally Constrained Inhibitors Targeting EGFR
期刊论文
OAI收割
ACS MEDICINAL CHEMISTRY LETTERS, 2013, 卷号: 4, 期号: 10, 页码: 974-978
作者:
Wu, Jianwei
;
Chen, Wenteng
;
Xia, Guangxin
;
Zhang, Jing
;
Shao, Jiaan
  |  
收藏
  |  
浏览/下载:49/0
  |  
提交时间:2019/01/08
Anticancer
kinase inhibitor
EGFR
conformationally constrained