机构

• 上海药物研究所 [7]

采集方式

• OAI收割 [7]

_filter

_filter

_filter

筛选

浏览/检索结果: 共7条，第1-7条 帮助 条数/页： 5101520253035404550556065707580859095100 排序方式： 请选择作者升序作者降序题名升序题名降序发表日期升序发表日期降序提交时间升序提交时间降序 Development of novel epoxyketone macrocyclic peptidyl proteasome inhibitors through OPA-mediated one-step cyclization of unprotected peptides 期刊论文  OAI收割 BIOORGANIC CHEMISTRY, 2025, 卷号: 156, 页码: 16 作者:  Zeng, Gongruixue;  Xu, Gaoya;  Gao, Lixin;  Zheng, Xiaoli;  Chi, Xinglong   |  收藏  |  浏览/下载：13/0  |  提交时间：2025/04/01 Proteasome inhibitors  Macrocycle  Stability  Anti-cancer activities   Exploration of novel 20S proteasome activators featuring anthraquinone structures and their application in hypoxic cardiomyocyte protection 期刊论文  OAI收割 BIOORGANIC & MEDICINAL CHEMISTRY, 2024, 卷号: 115, 页码: 10 作者:  Yu, Qian;  Gao, Lixin;  Xu, Linhao;  Han, Yubing;  Cao, Yu   |  收藏  |  浏览/下载：15/0  |  提交时间：2024/12/11 Proteasome activation: A novel strategy for targeting undruggable intrinsically disordered proteins 期刊论文  OAI收割 BIOORGANIC CHEMISTRY, 2024, 卷号: 145, 页码: 17 作者:  Yu, Qian;  Wang, Zheng;  Tu, Yutong;  Cao, Yu;  Zhu, Huajian   |  收藏  |  浏览/下载：19/0  |  提交时间：2024/05/07 20S proteasome  Proteasome activation  IDPs  Undruggable  Protein homeostasis   Exploration of novel four-membered-heterocycle constructed peptidyl proteasome inhibitors with improved metabolic stability for cancer treatment 期刊论文  OAI收割 BIOORGANIC CHEMISTRY, 2023, 卷号: 138, 页码: 22 作者:  Wang, Hanlin;  Wu, Zhaoxiao;  Cao, Yu;  Gao, Lixin;  Shao, Jiaan   |  收藏  |  浏览/下载：27/0  |  提交时间：2023/10/17 Metabolic stability  Four-membered heterocycles  Proteasome inhibitors  Multiple myeloma   Metabolism guided optimization of peptidomimetics as non-covalent proteasome inhibitors for cancer treatment 期刊论文  OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2022, 卷号: 233, 页码: 18 作者:  Cao, Yu;  Tu, Yutong;  Fu, Liping;  Yu, Qian;  Gao, Lixin   |  收藏  |  浏览/下载：52/0  |  提交时间：2022/06/15 Metabolism  Design  Proteasome inhibitors  Non-covalent  Multiple myeloma   A Chemical Tuned Strategy to Develop Novel Irreversible EGFR-TK Inhibitors with Improved Safety and Pharmacokinetic Profiles 期刊论文  OAI收割 JOURNAL OF MEDICINAL CHEMISTRY, 2014, 卷号: 57, 期号: 23, 页码: 9889-9900 作者:  Xia, Guangxin;  Chen, Wenteng;  Zhang, Jing;  Shao, Jiaan;  Zhang, Yong   |  收藏  |  浏览/下载：46/0  |  提交时间：2019/01/08 Design, Synthesis, and Biological Evaluation of Novel Conformationally Constrained Inhibitors Targeting EGFR 期刊论文  OAI收割 ACS MEDICINAL CHEMISTRY LETTERS, 2013, 卷号: 4, 期号: 10, 页码: 974-978 作者:  Wu, Jianwei;  Chen, Wenteng;  Xia, Guangxin;  Zhang, Jing;  Shao, Jiaan   |  收藏  |  浏览/下载：58/0  |  提交时间：2019/01/08 Anticancer  kinase inhibitor  EGFR  conformationally constrained