机构

• 高能物理研究所 [167]
• 近代物理研究所 [54]
• 上海药物研究所 [19]
• 物理研究所 [1]
• 地球化学研究所 [1]
• 植物研究所 [1]
• 更多

采集方式

• iSwitch采集 [167]
• OAI收割 [76]

内容类型

• 期刊论文 [243]

发表日期

• 2025 [1]
• 2024 [7]
• 2023 [6]
• 2022 [4]
• 2021 [1]
• 2020 [1]
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学科主题

• Physics [1]

筛选

浏览/检索结果: 共243条，第1-10条 帮助 条数/页： 5101520253035404550556065707580859095100 排序方式： 请选择题名升序题名降序提交时间升序提交时间降序作者升序作者降序发表日期升序发表日期降序 Discovery of novel covalent stabilizers for p53 Y220C using structure-based drug discovery methods 期刊论文  OAI收割 MOLECULAR DIVERSITY, 2025, 页码: 14 作者:  Wen, Yiming;  Xu, Peijia;  Chen, Yijie;  Meng, Jingyi;  Zheng, Mingyue   |  收藏  |  浏览/下载：9/0  |  提交时间：2025/04/01 p53 Y220C  Covalent stabilizer  Virtual screening  Molecular dynamics  DNA binding  Structure-activity relationship  Cancer therapy   SurfDock is a surface-informed diffusion generative model for reliable and accurate protein-ligand complex prediction 期刊论文  OAI收割 NATURE METHODS, 2024, 页码: 24 作者:  Cao, Duanhua;  Chen, Mingan;  Zhang, Runze;  Wang, Zhaokun;  Huang, Manlin   |  收藏  |  浏览/下载：4/0  |  提交时间：2025/01/06 Targeting STING oligomerization with licochalcone D ameliorates STING-driven inflammatory diseases 期刊论文  OAI收割 SCIENCE CHINA-LIFE SCIENCES, 2024, 页码: 14 作者:  Zhang, Yinghui;  Liu, Yadan;  Jiang, Bing;  Chen, Lifan;  Hu, Jie   |  收藏  |  浏览/下载：19/0  |  提交时间：2024/10/21 cGAS-STING signaling  STING inhibitor  TransformerCPI model  Licochalcone D  inflammatory diseases   Generic protein-ligand interaction scoring by integrating physical prior knowledge and data augmentation modelling 期刊论文  OAI收割 NATURE MACHINE INTELLIGENCE, 2024, 页码: 21 作者:  Cao, Duanhua;  Chen, Geng;  Jiang, Jiaxin;  Yu, Jie;  Zhang, Runze   |  收藏  |  浏览/下载：19/0  |  提交时间：2024/07/12 KinomeMETA: a web platform for kinome-wide polypharmacology profiling with meta-learning 期刊论文  OAI收割 NUCLEIC ACIDS RESEARCH, 2024, 页码: 9 作者:  Li, Zhaojun;  Qu, Ning;  Zhou, Jingyi;  Sun, Jingjing;  Ren, Qun   |  收藏  |  浏览/下载：33/0  |  提交时间：2024/06/27 Targeting JMJD1C to selectively disrupt tumor Treg cell fitness enhances antitumor immunity 期刊论文  OAI收割 NATURE IMMUNOLOGY, 2024, 页码: 32 作者:  Long, Xuehui;  Zhang, Sulin;  Wang, Yuliang;  Chen, Jingjing;  Lu, Yanlai   |  收藏  |  浏览/下载：40/0  |  提交时间：2024/03/25 Synthesis and Biological Evaluation of β-Lactam Derivatives Targeting Speckle-Type POZ Protein (SPOP) 期刊论文  OAI收割 ACS MEDICINAL CHEMISTRY LETTERS, 2024, 卷号: 15, 期号: 2, 页码: 270-279 作者:  Zhou, Chenmao;  Hao, Xinyue;  Chen, Zhengyang;  Zhang, Runze;  Zhou, Qian   |  收藏  |  浏览/下载：40/0  |  提交时间：2024/03/13 Speckle-type POZ protein (SPOP)  SPOP inhibitors  Clear cell renal cell carcinoma (ccRCC)  Structure-activityrelationship (SAR)   Long-Term Variation Characteristics and Health Risks of Atmospheric Hg in the Largest City in Northwestern China 期刊论文  OAI收割 Toxics, 2024, 卷号: 12, 期号: 12 作者:  Yuqi Pang;  Hongmei Xu;  Mengyun Yang;  Bin Zhang;  Liyan Liu   |  收藏  |  浏览/下载：9/0  |  提交时间：2025/03/12 Inhibiting sorting nexin 10 promotes mucosal healing through SREBP2-mediated stemness restoration of intestinal stem cells 期刊论文  OAI收割 SCIENCE ADVANCES, 2023, 卷号: 9, 期号: 35, 页码: 17 作者:  Bao, Weilian;  You, Yan;  Ni, Jiahui;  Hou, Hui;  Lyu, Jiaren   |  收藏  |  浏览/下载：14/0  |  提交时间：2023/12/08 Sequence-based drug design as a concept in computational drug design 期刊论文  OAI收割 NATURE COMMUNICATIONS, 2023, 卷号: 14, 期号: 1, 页码: 21 作者:  Chen, Lifan;  Fan, Zisheng;  Chang, Jie;  Yang, Ruirui;  Hou, Hui   |  收藏  |  浏览/下载：46/0  |  提交时间：2023/10/17