中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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De Novo siRNA nanoplatform with NIR-II imaging for treatment of carotid atherosclerotic plaques
期刊论文
OAI收割
CHEMICAL ENGINEERING JOURNAL, 2025, 卷号: 503, 页码: 13
作者:
Gao, Jialu
;
Zhu, Hua
;
Cai, Huanhuan
;
Ding, Qihang
;
Xiong, Xiaoxing
  |  
收藏
  |  
浏览/下载:4/0
  |  
提交时间:2025/02/28
siRNA delivery
Atheromatous plaques
NIR-II imaging
Multifunctional nanoplatform
Epsin1/2
Design, synthesis and pharmacological evaluation of 1,2,3,4-tetrahydrobenzofuro[2,3-c] pyridine derivatives as p21-activated kinase 4 inhibitors for treatment of pancreatic cancer
期刊论文
OAI收割
ACTA PHARMACEUTICA SINICA B, 2025, 卷号: 15, 期号: 1, 页码: 438-466
作者:
Li, Yang
;
Fang, Yan
;
Chen, Xiaoyu
;
Tong, Linjiang
;
Feng, Fang
  |  
收藏
  |  
浏览/下载:10/0
  |  
提交时间:2025/04/01
P21-activated kinase 4
Tetrahydrobenzofuro[2
3-c]pyridine
Structure-activity relationship
Allosteric inhibitor
Pharmacokinetics properties
Kinase selectivity
Pancreatic cancer
Immune infiltration
Integrative study of lung cancer adeno-to-squamous transition in EGFR TKI resistance identifies RAPGEF3 as a therapeutic target
期刊论文
OAI收割
NATIONAL SCIENCE REVIEW, 2024, 卷号: 11, 期号: 12, 页码: 20
作者:
Wang, Hua
;
Tang, Shijie
;
Wu, Qibiao
;
He, Yayi
;
Zhu, Weikang
  |  
收藏
  |  
浏览/下载:14/0
  |  
提交时间:2025/02/28
EGFR-mutant lung cancer
adeno-to-squamous transition
tyrosine kinase inhibitor resistance
transcription factor network
RAPGEF3
π-HuB: the proteomic navigator of the human body
期刊论文
OAI收割
NATURE, 2024, 卷号: 636, 期号: 8042, 页码: 322-331
作者:
He, Fuchu
;
Aebersold, Ruedi
;
Baker, Mark S.
;
Bian, Xiuwu
;
Bo, Xiaochen
  |  
收藏
  |  
浏览/下载:11/0
  |  
提交时间:2025/04/01
Design, Synthesis, and Biological Evaluation of Novel Diaminopyrimidine Macrocycles as Fourth Generation Reversible EGFR Inhibitors That Overcome Clinical Resistance to Osimertinib Mediated by C797S Mutation
期刊论文
OAI收割
JOURNAL OF MEDICINAL CHEMISTRY, 2024, 卷号: 67, 期号: 22, 页码: 20531-20558
作者:
Hu, Shiliang
;
Tong, Linjiang
;
Qin, Qiao
;
Wen, Jiaxin
;
Li, Yan
  |  
收藏
  |  
浏览/下载:8/0
  |  
提交时间:2024/12/11
INHBA promotes tumor growth and induces resistance to PD-L1 blockade by suppressing IFN-γ signaling
期刊论文
OAI收割
ACTA PHARMACOLOGICA SINICA, 2024, 页码: 14
作者:
Li, Fang-lin
;
Gu, Long-hua
;
Tong, Yong-liang
;
Chen, Run-qiu
;
Chen, Shi-yi
  |  
收藏
  |  
浏览/下载:14/0
  |  
提交时间:2024/10/21
cancer immunotherapy
INHBA
Activin A
IFN-gamma signaling pathway
PD-L1
Branched-chain amino acid transaminase 1 confers EGFR-TKI resistance through epigenetic glycolytic activation
期刊论文
OAI收割
SIGNAL TRANSDUCTION AND TARGETED THERAPY, 2024, 卷号: 9, 期号: 1, 页码: 17
作者:
Zhang, Tao
;
Pan, Zilu
;
Gao, Jing
;
Wu, Qingqing
;
Bai, Gang
  |  
收藏
  |  
浏览/下载:16/0
  |  
提交时间:2024/10/21
Discovery of a novel BTK inhibitor S-016 and identification of a new strategy for the treatment of lymphomas including BTK inhibitor-resistant lymphomas
期刊论文
OAI收割
ACTA PHARMACOLOGICA SINICA, 2024, 页码: 11
作者:
Song, Pei-ran
;
Wan, Zhi-peng
;
Huang, Ge-ge
;
Song, Zi-lan
;
Zhang, Tao
  |  
收藏
  |  
浏览/下载:64/0
  |  
提交时间:2024/07/12
diffuse large B-cell lymphoma
BTK inhibitors
drug resistance
BTK C481F
BTK A428D
SYHA1813
Cryo-EM structure of human HCN3 channel and its regulation by cAMP
期刊论文
OAI收割
JOURNAL OF BIOLOGICAL CHEMISTRY, 2024, 卷号: 300, 期号: 6, 页码: 10
作者:
Yu, Bo
;
Lu, Qiuyuan
;
Li, Jian
;
Cheng, Xinyu
;
Hu, Han
  |  
收藏
  |  
浏览/下载:11/0
  |  
提交时间:2024/12/11
Enhanced electrocaloric effect by configurational entropy change in (Ba,Sr, Ca,Bi,Li)TiO3 3 system
期刊论文
OAI收割
CERAMICS INTERNATIONAL, 2024, 卷号: 50
作者:
Xie, Lei
;
Zhao, Gaochao
;
Dong, Wei
;
Dong, Funing
;
Dou, Jinquan
  |  
收藏
  |  
浏览/下载:8/0
  |  
提交时间:2024/11/20
Electrocaloric effect
Ferroelectric
High entropy