中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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上海药物研究所 [140]
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Conformational restriction enables discovering a series of chroman derivatives as potent and selective NaV1.8 inhibitors with improved pharmacokinetic properties
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2025, 卷号: 293, 页码: 24
作者:
Li, Na
;
Wang, Linlin
;
Hu, Xinyuan
;
Xu, Haiyan
;
Yang, Bowen
  |  
收藏
  |  
浏览/下载:1/0
  |  
提交时间:2025/08/20
Voltage-gated sodium channel 1.8
Conformational restriction
Pharmacokinetic
Structure-activity relationship
Analgesic
EP240801a/XRF 240801B: An X-Ray Flash Detected by the Einstein Probe and the Implications of Its Multiband Afterglow
期刊论文
OAI收割
ASTROPHYSICAL JOURNAL LETTERS, 2025, 卷号: 988, 期号: 1
作者:
Jiang, Shuai-Qing
;
Xu, Dong
;
Hoof, Agnes P. C. van
;
Lei, Wei-Hua
;
Liu, Yuan
  |  
收藏
  |  
浏览/下载:23/0
  |  
提交时间:2025/07/28
Androgens alleviate the depression-like phenotype in female mice by inhibiting AVPR1a in the hippocampal brain region
期刊论文
OAI收割
MOLECULAR MEDICINE, 2025, 卷号: 31, 期号: 1, 页码: 15
作者:
Ren, Shimin
;
Wang, Xian
;
Huang, Xueying
;
Chen, Liyang
;
Zhang, Bing
  |  
收藏
  |  
浏览/下载:1/0
  |  
提交时间:2025/08/20
Androgen receptors
AVPR1a
Female
Depression
DHEA
Hippocampus
Discovery of novel GluN1/GluN3A NMDA receptor inhibitors using a deep learning-based method
期刊论文
OAI收割
ACTA PHARMACOLOGICA SINICA, 2025, 页码: 8
作者:
Wang, Shi-hang
;
Zeng, Yue
;
Yang, Hao
;
Tian, Si-yuan
;
Zhou, Yong-qi
  |  
收藏
  |  
浏览/下载:10/0
  |  
提交时间:2025/07/25
N
-methyl-
D
-aspartate receptors
GluN1/GluN3A
ligand-based virtual screening
scaffold hopping
deep learning
GeminiMol
Discovery of 3-(Fluoro-imidazolyl)pyridazine Derivatives as Potent STING Agonists with Antitumor Activity
期刊论文
OAI收割
JOURNAL OF MEDICINAL CHEMISTRY, 2025, 卷号: 68, 期号: 10, 页码: 9864-9885
作者:
Hou, Hui
;
Zhou, Jingyi
;
Sui, Qibang
;
Zhang, Changfa
;
Su, Zhaoming
  |  
收藏
  |  
浏览/下载:11/0
  |  
提交时间:2025/07/25
Proteogenomic characterization of non-functional clinically relevant subgroups
期刊论文
OAI收割
CANCER CELL, 2025, 卷号: 43, 期号: 4, 页码: 36
作者:
Ji, Shunrong
;
Cao, Lihua
;
Gao, Jing
;
Du, Yang
;
Ye, Zeng
  |  
收藏
  |  
浏览/下载:30/0
  |  
提交时间:2025/06/23
An efficient deep learning-based strategy to screen inhibitors for GluN1/GluN3A receptor
期刊论文
OAI收割
ACTA PHARMACOLOGICA SINICA, 2025, 页码: 9
作者:
Wang, Ze-chen
;
Zeng, Yue
;
Sun, Jin-yuan
;
Chen, Xue-qin
;
Wu, Hao-chen
  |  
收藏
  |  
浏览/下载:13/0
  |  
提交时间:2025/04/24
deep learning
scoring function
GluN1/GluN3A receptor
N
-methyl-
D
-aspartate (NMDA) receptor
virtual screening
drug discovery
Science objectives of the Einstein Probe mission
期刊论文
OAI收割
SCIENCE CHINA-PHYSICS MECHANICS & ASTRONOMY, 2025, 卷号: 68, 期号: 3
作者:
Yuan, Weimin
;
Dai, Lixin
;
Feng, Hua
;
Jin, Chichuan
  |  
收藏
  |  
浏览/下载:87/0
  |  
提交时间:2025/02/13
Einstein Probe
X-ray astronomy
X-ray telescopes
time-domain astronomy
transients
variability
Terrestrial ecosystem response to Early Cretaceous global environmental change: A calibrated, high-resolution Aptian record from Northeast China
期刊论文
OAI收割
EARTH AND PLANETARY SCIENCE LETTERS, 2025, 卷号: 653, 页码: 13
作者:
Sun, Ming-Dao
;
Lin, Qin
;
Ramezani, Jahandar
;
Liu, Jiang-Si
;
Lu, Zheng-An
  |  
收藏
  |  
浏览/下载:46/0
  |  
提交时间:2025/04/03
Early Cretaceous
Aptian
CA-ID-TIMS geochronology
Astrochronology
Carbon isotope stratigraphy
An improved equivalent constitutive model for layered rock mass considering layer structure and the effect of asymptotic deterioration of deformation and strength
期刊论文
OAI收割
COMPUTERS AND GEOTECHNICS, 2025, 卷号: 179, 页码: 23
作者:
  |  
收藏
  |  
浏览/下载:11/0
  |  
提交时间:2025/06/27
Layered rock mass
Constitutive model
Layer structure
Asymptotic deterioration