中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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CAS IR Grid
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西北高原生物研究... [154]
上海药物研究所 [68]
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Design, synthesis and biological evaluation of Alisol B derivatives for potential treatment of non-alcoholic steatohepatitis
期刊论文
OAI收割
BIOORGANIC CHEMISTRY, 2025, 卷号: 155, 页码: 15
作者:
Yu, Nai-Rong
;
Huang, Suling
;
Deng, Zhen-Tao
;
Wang, Jiayue
;
Shen, Yu
  |  
收藏
  |  
浏览/下载:9/0
  |  
提交时间:2025/04/01
Non-alcoholic steatohepatitis (NASH)
Alisol B
Structural modification
Structure-activity relationship
HFD+CCl4-induced NASH mice model
One stone two birds: Introducing piperazine into a series of nucleoside derivatives as potent and selective PRMT5 inhibitors
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2025, 卷号: 281, 页码: 18
作者:
Li, Huaxuan
;
Yang, Hong
;
Liu, Li
;
Zheng, Jiahong
;
Shi, Qiongyu
  |  
收藏
  |  
浏览/下载:12/0
  |  
提交时间:2024/12/11
Protein arginine methyltransferase 5
Nucleoside derivatives
Piperazine
Metabolic stability
Symmetric dimethylarginines
Quantifying Global Hydrological Sensitivity to CO2 Physiological and Radiative Forcings Under Large CO2 Increases
期刊论文
OAI收割
EARTHS FUTURE, 2024, 卷号: 12, 期号: 12, 页码: e2023EF004246
作者:
Zhang, Xuanze
;
Zhang, Yongqiang
;
Wang, Ying-Ping
;
Tang, Qiuhong
;
Ban, Yunyun
  |  
收藏
  |  
浏览/下载:3/0
  |  
提交时间:2025/01/17
global water cycle
hydrological sensitivity
vegetation physiological effect
CO2 radiative forcing
CMIP6
A visual cortex-inspired edge neuromorphic hardware architecture with on-chip multi-layer STDP learning
期刊论文
OAI收割
COMPUTERS & ELECTRICAL ENGINEERING, 2024, 卷号: 120, 页码: 17
作者:
He, Junxian
;
Tian, Min
;
Jiang, Ying
;
Wang, Haibing
;
Wang, Tengxiao
  |  
收藏
  |  
浏览/下载:5/0
  |  
提交时间:2024/12/06
Neuromorphic
Convolutional neuronal network
Spiking neural network
HMAX
STDP
On-chip learning
Emerging Pollutants
期刊论文
OAI收割
PROGRESS IN CHEMISTRY, 2024, 卷号: 36, 期号: 11, 页码: 1607-1784
作者:
Wang, Yawei
;
Zhang, Qiurui
;
Yu, Nanyang
;
Wang, Yuan
;
Wei, Si
  |  
收藏
  |  
浏览/下载:12/0
  |  
提交时间:2025/04/03
emerging pollutants
occurrence level
environmental behavior
ecological risks
control strategies
EGCG-enabled Deep Tumor Penetration of Phosphatase and Acidity Dual-responsive Nanotherapeutics for Combinatory Therapy of Breast Cancer
期刊论文
OAI收割
SMALL, 2024, 页码: 20
作者:
Zhou, Mengxue
;
Zhou, Chuang
;
Geng, Huan
;
Huang, Zhiwei
;
Lin, Zhiyuan
  |  
收藏
  |  
浏览/下载:4/0
  |  
提交时间:2024/12/16
chemo/chemodynamic therapy
EGCG
nanomedicine
TGF-beta signaling
triple-negative breast cancer
Synthesis and Biological Activity of Tetracyclic Dispiro Core Derivatives of Natural Products Dispirocochlearoids A-C
期刊论文
OAI收割
ORGANIC LETTERS, 2024, 卷号: 26, 期号: 45, 页码: 9654-9658
作者:
Pei, Junping
;
Wang, Ying
;
Shi, Shengjie
;
Chen, Linhai
;
Yin, Jianpeng
  |  
收藏
  |  
浏览/下载:5/0
  |  
提交时间:2024/12/11
Discovery of CZL-046 with an (
S
)-3-Fluoropyrrolidin-2-one Scaffold as a p300 Bromodomain Inhibitor for the Treatment of Multiple Myeloma
期刊论文
OAI收割
JOURNAL OF MEDICINAL CHEMISTRY, 2024, 卷号: 67, 期号: 20, 页码: 18606-18628
作者:
Chen, Zonglong
;
Yang, Hong
;
Zhang, Yan
;
Lyu, Xiaodong
;
Shi, Qiongyu
  |  
收藏
  |  
浏览/下载:8/0
  |  
提交时间:2024/11/05
Heterozygous variants in USP25 cause genetic generalized epilepsy
期刊论文
OAI收割
BRAIN, 2024, 页码: 16
作者:
Fan, Cui-Xia
;
Liu, Xiao-Rong
;
Mei, Dao-Qi
;
Li, Bing-Mei
;
Li, Wen-Bin
  |  
收藏
  |  
浏览/下载:10/0
  |  
提交时间:2024/10/09
genetic generalized epilepsy
USP25
gain of function
loss of function
Transcriptomic decoding of regional cortical vulnerability to major depressive disorder
期刊论文
OAI收割
COMMUNICATIONS BIOLOGY, 2024, 卷号: 7, 期号: 1, 页码: 12
作者:
Zhu, Jiajia
;
Chen, Xiao
;
Lu, Bin
;
Li, Xue-Ying
;
Wang, Zi-Han
  |  
收藏
  |  
浏览/下载:14/0
  |  
提交时间:2024/09/10