中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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CAS IR Grid
机构
上海药物研究所 [31]
广州地球化学研究所 [7]
自动化研究所 [7]
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期刊论文 [59]
会议论文 [5]
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Design and Development of a Novel Oral 4′-Fluorouridine Double Prodrug VV261 against SFTSV
期刊论文
OAI收割
JOURNAL OF MEDICINAL CHEMISTRY, 2025, 卷号: 68, 期号: 9, 页码: 9811-9826
作者:
Cheng, Yong
;
Zheng, Wei
;
Dong, Xinru
;
Sun, Tengxiao
;
Xu, Mengwei
  |  
收藏
  |  
浏览/下载:8/0
  |  
提交时间:2025/06/23
Design, synthesis, and evaluation of novel oxyacanthine derivatives for anti-SARS-CoV-2 activity
期刊论文
OAI收割
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2024, 卷号: 113, 页码: 5
作者:
Lu, Jie
;
Cheng, Yan
;
Zhang, Yumin
;
Wang, Yi
;
Xia, Bingqing
  |  
收藏
  |  
浏览/下载:13/0
  |  
提交时间:2025/02/28
Bisbenzylisoquinoline alkaloid
Oxyacanthine derivatives
SARS-CoV-2
Hygroscopic Properties of Plateau Surface Salts: Insights from Chemical Composition and Isotope Signatures
期刊论文
OAI收割
ACS EARTH AND SPACE CHEMISTRY, 2024, 卷号: 8, 期号: 5, 页码: 1111-1121
作者:
Hao, Yuxin
;
Qiu, Yuhe
;
Li, Jun
;
Liu, Wanyu
;
Chen, Lanxiadi
  |  
收藏
  |  
浏览/下载:26/0
  |  
提交时间:2024/09/13
hygroscopicity
salt evaporites
geochemicalisotopes
sulfur
chlorine
atmosphere
TPN10475 Constrains Effector T Lymphocytes Activation and Attenuates Experimental Autoimmune Encephalomyelitis Pathogenesis by Facilitating TGF-β Signal Transduction
期刊论文
OAI收割
JOURNAL OF NEUROIMMUNE PHARMACOLOGY, 2024, 卷号: 19, 期号: 1, 页码: 16
作者:
Wang, Chun
;
Jiang, Xiangrui
;
Lv, Jie
;
Zhuang, Wei
;
Xie, Ling
  |  
收藏
  |  
浏览/下载:46/0
  |  
提交时间:2024/04/09
Experimental autoimmune encephalomyelitis
TGF-beta signal transduction
Effector CD4(+) T cells activation
Th/Treg
Cell migration
Glimepiride, a novel soluble epoxide hydrolase inhibitor, protects against heart failure via increasing epoxyeicosatrienoic acids
期刊论文
OAI收割
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 2023, 卷号: 185, 页码: 13-25
作者:
Zhao, Chengcheng
;
Jiang, Xiangrui
;
Peng, Liyuan
;
Zhang, Yan
;
Li, Huihui
  |  
收藏
  |  
浏览/下载:51/0
  |  
提交时间:2024/01/16
Heart failure
Hypertrophy
Epoxyeicosatrienoic acids
Soluble epoxide hydrolase
TPN10475 alleviates concanavalin A-induced autoimmune hepatitis by limiting T cell development and function through inhibition of PI3K-AKT pathway
期刊论文
OAI收割
INTERNATIONAL IMMUNOPHARMACOLOGY, 2023, 卷号: 125, 页码: 13
作者:
Wang, Chun
;
Han, Mengyao
;
Li, Xinhang
;
Lv, Jie
;
Zhuang, Wei
  |  
收藏
  |  
浏览/下载:41/0
  |  
提交时间:2024/01/16
AIH
T cell
Pro-inflammatory
IFN-gamma
PI3K-AKT
The novel small molecule TPN10518 alleviates EAE pathogenesis by inhibiting AP1 to depress Th1/Th17 cell differentiation
期刊论文
OAI收割
INTERNATIONAL IMMUNOPHARMACOLOGY, 2023, 卷号: 123, 页码: 12
作者:
Xie, Ling
;
Lv, Jie
;
Saimaier, Kaidireya
;
Han, Sanxing
;
Han, Mengyao
  |  
收藏
  |  
浏览/下载:28/0
  |  
提交时间:2023/10/17
TPN10518
Th1/Th17 cells
AP1
Experimental autoimmune encephalomyelitis
A new Einstein coefficient method for mesopause–lower thermosphere atmosphere temperature retrieval under a non-local thermal equilibrium situation
期刊论文
OAI收割
Optics Express, 2023, 卷号: 31, 期号: 19, 页码: 30413-30434
作者:
Li, Haotian
;
Feng, Yutao
;
Li, Faquan
;
Wang, Houmao
;
Hu, Xiangrui
  |  
收藏
  |  
浏览/下载:26/0
  |  
提交时间:2023/10/26
Efficacy and safety of SIM0417 (SSD8432) plus ritonavir for COVID-19 treatment: a randomised, double-blind, placebo- controlled, phase 1b trial
期刊论文
OAI收割
LANCET REGIONAL HEALTH-WESTERN PACIFIC, 2023, 卷号: 38, 页码: 13
作者:
Wang, Fuxiang
;
Xiao, Wen
;
Tang, Yimin
;
Cao, Mengli
;
Shu, Dan
  |  
收藏
  |  
浏览/下载:34/0
  |  
提交时间:2023/10/17
Covid-19
3CL protease inhibitor
SARS-CoV-2 viral load
Alleviation of COVID-19 symptoms
Preventive and therapeutic benefits of nelfinavir in rhesus macaques and human beings infected with SARS-CoV-2
期刊论文
OAI收割
Signal Transduction and Targeted Therapy, 2023, 卷号: 8, 期号: 5, 页码: 2384-2391
作者:
Xu, Zhijian
;
Shi, Danrong
;
Han, Jianbao
;
Ling, Yun
;
Jiang, Xiangrui
  |  
收藏
  |  
浏览/下载:47/0
  |  
提交时间:2024/03/27