中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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CAS IR Grid
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广州生物医药与健康... [10]
上海药物研究所 [7]
金属研究所 [4]
国家天文台 [2]
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期刊论文 [30]
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2023 [1]
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Biochemis... [11]
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Spatial and Temporal Patterns of Carbon and Water Use Efficiency on the Loess Plateau and Their Influencing Factors
期刊论文
OAI收割
LAND, 2023, 卷号: 12, 期号: 1, 页码: 16
作者:
Zhang, Qi
;
Lu, Jinxin
;
Xu, Xuexuan
;
Ren, Xiuzi
;
Wang, Junfeng
  |  
收藏
  |  
浏览/下载:14/0
  |  
提交时间:2023/03/03
Loess Plateau
carbon and water use efficiency
climate change
human activities
Structure-based rational design enables efficient discovery of a new selective and potent AKT PROTAC degrader
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2022, 卷号: 238, 页码: 15
作者:
Zhu, Cheng-Liang
;
Luo, Xiaomin
;
Tian, Tian
;
Rao, Zijian
;
Wang, Hanlin
  |  
收藏
  |  
浏览/下载:30/0
  |  
提交时间:2022/08/16
AKT
Protein kinase B
PROTAC
Chemical degrader
Rational design
Structural Feature Analyzation Strategies toward Discovery of Orally Bioavailable PROTACs of Bruton's Tyrosine Kinase for the Treatment of Lymphoma
期刊论文
OAI收割
JOURNAL OF MEDICINAL CHEMISTRY, 2022, 卷号: 65, 期号: 13, 页码: 9096–9125
作者:
Zhang, Jingyu
;
Che, Jinxin
;
Luo, Xiaomin
;
Wu, Mingfei
;
Kan, Weijuan
  |  
收藏
  |  
浏览/下载:21/0
  |  
提交时间:2024/03/21
Design, synthesis and biological evaluation of sulfonamides inhibitors of XPO1 displaying activity against multiple myeloma cells
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2022, 卷号: 235
作者:
Qu, Bingxue
;
Xu, Yongjin
;
Lu, Yang
;
Zhuang, Weihao
;
Jin, Xinxin
  |  
收藏
  |  
浏览/下载:25/0
  |  
提交时间:2022/12/23
XPO1
Multiple myeloma
MM.1S
N-phenylsulfonamide
Oral administration
Discovery of seneciobipyrrolidine derivatives for the amelioration of glucose homeostasis disorders through 4E-BP1/Akt/AMPK signaling activation
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2022, 卷号: 228, 页码: 25
作者:
Che, Jinxin
;
Ma, Canliang
;
Lu, Jialiang
;
Chen, Binhui
;
Shi, Qiuqiu
  |  
收藏
  |  
浏览/下载:31/0
  |  
提交时间:2022/06/15
Seneciobipyrrolidine
Phenotypic screening
Glucose homeostasis
Proteomic analysis
L6 myotubes
4E-BP1
Multiscale characterization reveals oligomerization dependent phase separation of primer-independent RNA polymerase nsp8 from SARS-CoV-2
期刊论文
OAI收割
COMMUNICATIONS BIOLOGY, 2022, 卷号: 5, 期号: 1, 页码: 925
作者:
Xu, Jinxin
;
Jiang, Xin
;
Zhang, Yulong
;
Dong, Yan
;
Ma, Changli
  |  
收藏
  |  
浏览/下载:5/0
  |  
提交时间:2023/11/09
Structure-based design, synthesis and bioactivity evaluation of macrocyclic inhibitors of mutant isocitrate dehydrogenase 2 (IDH2) displaying activity in acute myeloid leukemia cells
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2020, 卷号: 203, 页码: 19
作者:
Che, Jinxin
;
Huang, Feng
;
Zhang, Mengmeng
;
Xu, Gaoya
;
Qu, Bingxue
  |  
收藏
  |  
浏览/下载:42/0
  |  
提交时间:2020/12/21
Metabolic pathways
Isocitrate dehydrogenase 2
Conformational restriction
Macrocyclic derivatives
Inhibitors
Structure-based design, synthesis and bioactivity evaluation of macrocyclic inhibitors of mutant isocitrate dehydrogenase 2 (IDH2) displaying activity in acute myeloid leukemia cells
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2020, 卷号: 203, 页码: 19
作者:
Che, Jinxin
;
Huang, Feng
;
Zhang, Mengmeng
;
Xu, Gaoya
;
Qu, Bingxue
  |  
收藏
  |  
浏览/下载:26/0
  |  
提交时间:2020/12/21
Metabolic pathways
Isocitrate dehydrogenase 2
Conformational restriction
Macrocyclic derivatives
Inhibitors
In vitro insights into the role of copper ions released from selective laser melted CoCrW-xCu alloys in the potential attenuation of inflammation and osteoclastogenesis
期刊论文
OAI收割
JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY, 2020, 卷号: 41, 页码: 56-67
作者:
Lu, Yanjin
;
Xu, Xiongcheng
;
Yang, Chunguang
;
Ren, Ling
;
Luo, Kai
  |  
收藏
  |  
浏览/下载:14/0
  |  
提交时间:2021/02/02
Osteoclast
Selective laser melting
Macrophage
Cu-bearing biomedical alloy
Biocompatibility
Site-testing at Muztagh-ata site I: ground meteorology and sky brightness
期刊论文
OAI收割
RESEARCH IN ASTRONOMY AND ASTROPHYSICS, 2020, 卷号: 20, 期号: 6
作者:
Xu, Jing
;
Esamdin, Ali
;
Hao, JinXin
;
Bai, JinMin
;
Yang, Ji
  |  
收藏
  |  
浏览/下载:26/0
  |  
提交时间:2021/12/06
TELESCOPE
site-testing
meteorological condition
optical observing