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PRIMER EXTENSION ENRICHMENTREACTION (PEER) AND OTHER METHODSFOR DIFFERENCE SCREENING
期刊论文
OAI收割
Nucleic Acids Hybridization, 3111, 页码: 125-165
作者:
Qi Jun ZHANG
;
Hui DOU
;
Qun Xiong ZHENG
;
Chang Xin ZHOU
;
Zhao Jun XU
  |  
收藏
  |  
浏览/下载:342/0
  |  
提交时间:2017/07/19
Conformational restriction enables discovering a series of chroman derivatives as potent and selective NaV1.8 inhibitors with improved pharmacokinetic properties
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2025, 卷号: 293, 页码: 24
作者:
Li, Na
  |  
收藏
  |  
浏览/下载:1/0
  |  
提交时间:2025/08/20
Voltage-gated sodium channel 1.8
Conformational restriction
Pharmacokinetic
Structure-activity relationship
Analgesic
Immunosuppressive nitrogen-containing triterpenoid saponins from
Mussaenda
erosa
and the therapeutic efficacy of heinsiagenin A in a murine lupus erythematosus model
期刊论文
OAI收割
BIOORGANIC CHEMISTRY, 2025, 卷号: 163, 页码: 11
作者:
Xu, Yidan
;
Xiang, Mai
;
Chang, Yuan
;
Chen, Zhenhua
;
Zhang, Rujun
  |  
收藏
  |  
浏览/下载:1/0
  |  
提交时间:2025/08/20
Mussaenda erosa
Nitrogen-containing triterpenoid saponins
Immunosuppressive activity
Autoimmune diseases
Heinsiagenin A
EP240801a/XRF 240801B: An X-Ray Flash Detected by the Einstein Probe and the Implications of Its Multiband Afterglow
期刊论文
OAI收割
ASTROPHYSICAL JOURNAL LETTERS, 2025, 卷号: 988, 期号: 1
作者:
Jiang, Shuai-Qing
;
Xu, Dong
;
Hoof, Agnes P. C. van
;
Lei, Wei-Hua
;
Liu, Yuan
  |  
收藏
  |  
浏览/下载:20/0
  |  
提交时间:2025/07/28
Study of ultra-high-energy gamma-ray source 1LHAASO J0056+6346u and its possible origins
期刊论文
OAI收割
SCIENCE CHINA-PHYSICS MECHANICS & ASTRONOMY, 2025, 卷号: 68, 期号: 7
作者:
Cao, Zhen
;
Aharonian, F.
;
Axikegu
;
Bai, Y. X.
;
Bao, Y. W.
  |  
收藏
  |  
浏览/下载:33/0
  |  
提交时间:2025/06/10
gamma rays
cosmic rays
supernova remnant
young massive cluster
pulsar
Crack propagation behavior in metal matrix composites: A coupled nonlocal crystal plasticity and phase field modelling
期刊论文
OAI收割
JOURNAL OF THE MECHANICS AND PHYSICS OF SOLIDS, 2025, 卷号: 200, 页码: 24
作者:
Xiong, Yukai
;
Zhao, Jianfeng
;
Zeng, Qinglei
;
Yuan, Fuping
;
Zhang, Xu
  |  
收藏
  |  
浏览/下载:9/0
  |  
提交时间:2025/07/22
Metal matrix composites
Nonlocal plasticity
Phase field method
Crack propagation
Geometrically necessary dislocations
Rapid Discovery of Celastrol Derivatives as Potent and Selective PRDX1 Inhibitors via Microplate-Based Parallel Compound Library and In Situ Screening
期刊论文
OAI收割
JOURNAL OF MEDICINAL CHEMISTRY, 2025, 卷号: 68, 期号: 13, 页码: 13609-13627
作者:
Chen, Shuang
;
Wang, Zhenyu
;
Gao, Jia
;
Wang, Yanlin
;
Liang, Jiayin
  |  
收藏
  |  
浏览/下载:5/0
  |  
提交时间:2025/08/20
De novo design of protein condensation inhibitors by targeting an allosteric site of cGAS
期刊论文
OAI收割
NATURE COMMUNICATIONS, 2025, 卷号: 16, 期号: 1, 页码: 20
作者:
Zhao, Wenfeng
;
Chen, Guofeng
;
He, Jian
;
Shen, Xiaofang
;
Xiong, Muya
  |  
收藏
  |  
浏览/下载:5/0
  |  
提交时间:2025/08/20
Development of Orally Bioavailable Octahydroindole-Based Peptidomimetic Derivative as a Broad-Spectrum Inhibitor against HCoV-OC43 and SARS-CoV-2
期刊论文
OAI收割
JOURNAL OF MEDICINAL CHEMISTRY, 2025, 卷号: 68, 期号: 11, 页码: 10823-10844
作者:
Hu, Shulei
;
Zhang, Yumin
;
Wang, Chenchen
;
Li, Jian
;
Su, Haixia
  |  
收藏
  |  
浏览/下载:19/0
  |  
提交时间:2025/07/25
Discovery of Hydrazineyl Amide Derivative of Pseudolaric Acid B for Reprogramming Tumor-Associated Macrophages Against Tumor Growth
期刊论文
OAI收割
MOLECULES, 2025, 卷号: 30, 期号: 10, 页码: 22
作者:
Peng, Xia
;
Yu, Siqi
;
Xu, Lin
;
Wang, Qinghua
;
Yang, Lin
  |  
收藏
  |  
浏览/下载:16/0
  |  
提交时间:2025/07/25
pseudolaric acid B
amide derivatives
tumor-associated macrophages
anti-tumor
repolarization