机构

• 上海药物研究所 [15]
• 大连化学物理研究所 [1]
• 深海科学与工程研究所 [1]

采集方式

• OAI收割 [17]

内容类型

• 期刊论文 [16]
• 会议论文 [1]

发表日期

• 2025 [1]
• 2024 [4]
• 2023 [3]
• 2022 [3]
• 2021 [3]
• 2019 [2]
• 更多

学科主题

筛选

浏览/检索结果: 共17条，第1-10条 帮助 条数/页： 5101520253035404550556065707580859095100 排序方式： 请选择题名升序题名降序提交时间升序提交时间降序作者升序作者降序发表日期升序发表日期降序 Discovery of Novel RNA Demethylase FTO Inhibitors Featuring an Acylhydrazone Scaffold with Potent Antileukemia Activity 期刊论文  OAI收割 JOURNAL OF MEDICINAL CHEMISTRY, 2025, 页码: 22 作者:  Liang, Xuewu;  Huang, Yue;  Ren, Hairu;  Liu, Qi;  Chen, Liang   |  收藏  |  浏览/下载：7/0  |  提交时间：2025/04/01 Discovery of Novel 2-Aminopyridine-Based and 2-Aminopyrimidine-Based Derivatives as Potent CDK/HDAC Dual Inhibitors for the Treatment of Refractory Solid Tumors and Hematological Malignancies 期刊论文  OAI收割 JOURNAL OF MEDICINAL CHEMISTRY, 2024, 卷号: 67, 期号: 17, 页码: 15220-15245 作者:  Saidahmatov, Abdusaid;  Li, Jianan;  Xu, Shihao;  Hu, Xiaobei;  Gao, Xiangqian   |  收藏  |  浏览/下载：20/0  |  提交时间：2024/10/21 Discovery of Novel Pyrimidine-Based Derivatives as Nav1.2 Inhibitors with Efficacy in Mouse Models of Epilepsy 期刊论文  OAI收割 JOURNAL OF MEDICINAL CHEMISTRY, 2024, 卷号: 67, 期号: 15, 页码: 12912-12931 作者:  He, Guoxue;  Zheng, Yueming;  Chang, Shunzhen;  Wang, Long;  Yang, Xiaohao   |  收藏  |  浏览/下载：17/0  |  提交时间：2024/09/26 Discovery and Optimization of Novel Nonbile Acid FXR Agonists as Preclinical Candidates for the Treatment of Inflammatory Bowel Disease 期刊论文  OAI收割 JOURNAL OF MEDICINAL CHEMISTRY, 2024, 卷号: 67, 期号: 7, 页码: 5642-5661 作者:  Li, Yuan;  Xu, Tingting;  Zhao, Yue;  Zhang, Hui;  Liu, Zesheng   |  收藏  |  浏览/下载：19/0  |  提交时间：2024/05/07 Development of Potent MALT1 Inhibitors Featuring a Novel "2-Thioxo-2,3-dihydrothiazolo[4,5-d]pyrimidin-7(6H)-one" Scaffold for the Treatment of B Cell Lymphoma 期刊论文  OAI收割 JOURNAL OF MEDICINAL CHEMISTRY, 2024, 卷号: 67, 期号: 4, 页码: 2884-2906 作者:  Liang, Xuewu;  Yu, Haolan;  Liang, Renwen;  Feng, Zhuanghui;  Saidahmatov, Abdusaid   |  收藏  |  浏览/下载：33/0  |  提交时间：2024/04/09 Structure-based drug discovery of novel fused- pyrazolone carboxamide derivatives as potent and selective AXL inhibitors 期刊论文  OAI收割 ACTA PHARMACEUTICA SINICA B, 2023, 卷号: 13, 期号: 12, 页码: 4918-4933 作者:  Fang, Feifei;  Dai, Yang;  Wang, Hao;  Ji, Yinchun;  Liang, Xuewu   |  收藏  |  浏览/下载：23/0  |  提交时间：2024/01/26 derivatives  Antitumor drug development  Potential AXL inhibitor  Antitumor activity  Structure-based drug design  Fused-pyrazolone carboxamide   The new direction of drug development: Degradation of undruggable targets through targeting chimera technology 期刊论文  OAI收割 MEDICINAL RESEARCH REVIEWS, 2023, 页码: 54 作者:  Liang, Xuewu;  Ren, Hairu;  Han, Fengyang;  Liang, Renwen;  Zhao, Jiayan   |  收藏  |  浏览/下载：39/0  |  提交时间：2024/01/16 chimeric design  degradation System  PROTAC  targeted degradation technology  undruggable targets   Construction of Diversified Penta-Spiro-Heterocyclic and Fused-Heterocyclic Frameworks with Potent Antitumor Activity 期刊论文  OAI收割 CHEMISTRY-A EUROPEAN JOURNAL, 2023, 页码: 7 作者:  Liu, Qi;  Liu, Xuyi;  Li, Yazhou;  Zhou, Yu;  Zhao, Linxiang   |  收藏  |  浏览/下载：19/0  |  提交时间：2023/10/17 spiro  fused-heterocyclic frameworks  substrate- and pH- controlled strategies  C-H activation  [4+1] and [4+2] annulation  antitumor  indazolone   Discovery of Novel Imidazo[4,5-c]quinoline Derivatives to Treat Inflammatory Bowel Disease (IBD) by Inhibiting Multiple Proinflammatory Signaling Pathways and Restoring Intestinal Homeostasis 期刊论文  OAI收割 JOURNAL OF MEDICINAL CHEMISTRY, 2022, 页码: 21 作者:  Liang, Xuewu;  Xie, Yongle;  Liu, Xuyi;  Xu, Hui;  Ren, Hairu   |  收藏  |  浏览/下载：46/0  |  提交时间：2022/11/11 Implementation and Evaluation of the ORB-SLAM3 in the Underwater Environment 会议论文  OAI收割 作者:  Yuxiao Li;  Xuewu Hong;  Jiancheng Liu;  Yuxiang Chen;  Lixin Xu   |  收藏  |  浏览/下载：12/0  |  提交时间：2022/11/03