中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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CAS IR Grid
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昆明植物研究所 [30]
上海药物研究所 [29]
武汉岩土力学研究所 [15]
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期刊论文 [236]
会议论文 [7]
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Discovery of pyrrolo[2,3-d]pyrimidin-4-one derivative YCH3124 as a potent USP7 inhibitor for cancer therapy
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2024, 卷号: 277, 页码: 17
作者:
Zhuang, Zhen
;
Miao, Yu-Ling
;
Song, Shan-Shan
;
Leng, Guang-Tong
;
Zhang, Xiao-Fei
  |  
收藏
  |  
浏览/下载:20/0
  |  
提交时间:2024/09/26
USP7 inhibitor
Structure-activity relationships
Anti-cancer
pyrrolo[2,3-d]pyrimidin-4-one
Identification of a dual functional betulinic acid analog for the treatment of osteoarthritis by phenotypic screening
期刊论文
OAI收割
SCIENCE CHINA-LIFE SCIENCES, 2024, 页码: 3
作者:
Lin, Ze-Min
;
Xiang, Mai
;
Wei, Wen-Hui
;
Fan, Shu-Hui
;
Chen, Li
  |  
收藏
  |  
浏览/下载:149/0
  |  
提交时间:2024/12/11
Transcriptomic decoding of regional cortical vulnerability to major depressive disorder
期刊论文
OAI收割
COMMUNICATIONS BIOLOGY, 2024, 卷号: 7, 期号: 1, 页码: 12
作者:
Zhu, Jiajia
;
Chen, Xiao
;
Lu, Bin
;
Li, Xue-Ying
;
Wang, Zi-Han
  |  
收藏
  |  
浏览/下载:13/0
  |  
提交时间:2024/09/10
Identification of YCH2823 as a novel USP7 inhibitor for cancer therapy
期刊论文
OAI收割
BIOCHEMICAL PHARMACOLOGY, 2024, 卷号: 222, 页码: 11
作者:
Cheng, Yong -Jun
;
Zhuang, Zhen
;
Miao, Yu -Ling
;
Song, Shan -Shan
;
Bao, Xu-Bin
  |  
收藏
  |  
浏览/下载:8/0
  |  
提交时间:2024/05/07
YCH2823
USP7 inhibitor
FT671
BCL6
mTOR inhibitor
DZ2002 alleviates corneal angiogenesis and inflammation in rodent models of dry eye disease via regulating STAT3-PI3KAkt-NF-kappa B pathway
期刊论文
OAI收割
ACTA PHARMACOLOGICA SINICA, 2023, 页码: 14
作者:
Wu, Chun-mei
;
Mao, Jia-wen
;
Zhu, Jin-zhi
;
Xie, Can-can
;
Yao, Jia-ying
  |  
收藏
  |  
浏览/下载:28/0
  |  
提交时间:2023/10/17
dry eye disease
DZ2002
corneal angiogenesis
immunomodulatory function
NF-kappa B
ophthalmic therapy
Pulsed counterclockwise rotation of the southwestern Sichuan Basin in response to the India-Asia convergence during 128-42 Ma
期刊论文
OAI收割
EARTH AND PLANETARY SCIENCE LETTERS, 2023, 卷号: 611, 页码: 15
作者:
Shen, Qi
;
Jin, Chun-Sheng
;
Liang, Wen-Tian
;
Li, Chuan-Zhi
;
Yang, Hui-Hui
  |  
收藏
  |  
浏览/下载:29/0
  |  
提交时间:2023/12/29
paleomagnetic rotation
Sichuan Basin
eastern Tibetan Plateau
extrusion tectonics
India-Asia collision
mantle plume
Predicting In Vitro and In Vivo Anti-SARS-CoV-2 Activities of Antivirals by Intracellular Bioavailability and Biochemical Activity
期刊论文
OAI收割
ACS OMEGA, 2022, 页码: 13
作者:
Zhang, Jinwen
;
He, Mingfeng
;
Xie, Qian
;
Su, Ailing
;
Yang, Kuangyang
  |  
收藏
  |  
浏览/下载:26/0
  |  
提交时间:2023/04/10
Solar X-ray and EUV imager on board the FY-3E satellite
期刊论文
OAI收割
LIGHT-SCIENCE & APPLICATIONS, 2022, 卷号: 11, 期号: 1, 页码: 13
作者:
Chen, Bo
;
Zhang, Xiao-Xin
;
He, Ling-Ping
;
Song, Ke-Fei
;
Liu, Shi-Jie
  |  
收藏
  |  
浏览/下载:43/0
  |  
提交时间:2023/03/31
Design, synthesis and evaluation of the Brigatinib analogues as potent inhibitors against tertiary EGFR mutants (EGFR(del19/T790M/C797S) and EGFR(L858R/T790M/C797S))
期刊论文
OAI收割
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2022, 卷号: 72, 页码: 11
作者:
Fang, Haotian
;
Wu, Yingming
;
Xiao, Qitao
;
He, Dongbo
;
Zhou, Tongrui
  |  
收藏
  |  
浏览/下载:122/0
  |  
提交时间:2022/08/16
Non-small cell lung cancer
EGFR
Triple mutations
C797S
EGFR-TKIs
Deletion of Schizophrenia Susceptibility Gene Ulk4 Leads to Abnormal Cognitive Behaviors via Akt-GSK-3 Signaling Pathway in Mice
期刊论文
OAI收割
SCHIZOPHRENIA BULLETIN, 2022, 页码: 10
作者:
Hu, Ling
;
Zhou, Bing-Yao
;
Yang, Cui-Ping
;
Lu, Da-Yun
;
Tao, Yun-Chao
  |  
收藏
  |  
浏览/下载:46/0
  |  
提交时间:2022/06/15
Unc-51-like kinase 4
schizophrenia
sensorimotor gating
Akt
GSK-3
cerebral cortex