机构

• 上海药物研究所 [10]
• 广州生物医药与健康研... [2]
• 深圳先进技术研究院 [1]
• 合肥物质科学研究院 [1]

采集方式

• OAI收割 [14]

内容类型

• 期刊论文 [14]

发表日期

• 2023 [1]
• 2022 [1]
• 2021 [1]
• 2018 [2]
• 2017 [1]
• 2016 [1]
• 更多

学科主题

• Biochemist... [2]
• Pharmacolo... [2]

筛选

浏览/检索结果: 共14条，第1-10条 帮助 条数/页： 5101520253035404550556065707580859095100 排序方式： 请选择题名升序题名降序提交时间升序提交时间降序作者升序作者降序发表日期升序发表日期降序 Discovery of HCD3514 as a potent EGFR inhibitor against C797S mutation in vitro and in vivo 期刊论文  OAI收割 JOURNAL OF CANCER, 2023, 卷号: 14, 期号: 1, 页码: 152-162 作者:  Lai, Mengzhen   |  收藏  |  浏览/下载：120/0  |  提交时间：2023/04/10 fourth-generation EGFR inhibitor  EGFRC797S mutation  NSCLC  drug resistance  small molecular inhibitor   Discovery of Pteridine-7(8H)-one Derivatives as Potent and Selective Inhibitors of Bruton's Tyrosine Kinase (BTK) 期刊论文  OAI收割 JOURNAL OF MEDICINAL CHEMISTRY, 2022, 卷号: 65, 期号: 3, 页码: 2694-2709 作者:  Dou, Dou;  Diao, Yanyan;  Sha, Wenjie;  Su, Rongrong;  Tong, Linjiang   |  收藏  |  浏览/下载：36/0  |  提交时间：2022/08/16 LS-106, a novel EGFR inhibitor targeting C797S, exhibits antitumor activities both in vitro and in vivo 期刊论文  OAI收割 CANCER SCIENCE, 2021, 页码: 12 作者:  Liu, Yingqiang;  Lai, Mengzhen;  Li, Shan;  Wang, Yanan;  Feng, Fang   |  收藏  |  浏览/下载：108/0  |  提交时间：2022/01/18 C797S  epidermal growth factor receptor  fourth-generation EGFR TKI  non-small cell lung cancer  osimertinib resistance   Discovery of 4,7-Diamino-5-(4-phenoxyphenyl)-6-methylene-pyrinnido[5,4-b]pyrrolizines as Novel Bruton's Tyrosine Kinase Inhibitors 期刊论文  OAI收割 JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 61, 期号: 10, 页码: 4608-4627 作者:  Xue, Yu;  Song, Peiran;  Song, Zilan;  Wang, Aoli;  Tong, Linjiang   |  收藏  |  浏览/下载：41/0  |  提交时间：2019/08/23 Discovery of 4,7-Diamino-5-(4-phenoxyphenyl)-6-methylene-pyrinnido[5,4-b]pyrrolizines as Novel Bruton's Tyrosine Kinase Inhibitors 期刊论文  OAI收割 JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 61, 期号: 10, 页码: 4608-4627 作者:  Xue, Yu;  Song, Peiran;  Song, Zilan;  Wang, Aoli;  Tong, Linjiang   |  收藏  |  浏览/下载：50/0  |  提交时间：2019/01/08 A structure-guided optimization of pyrido[2,3-d]pyrimidin-7-ones as selective inhibitors of EGFR(L858R/T790M) mutant with improved pharmacokinetic properties 期刊论文  OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2017, 卷号: 126, 页码: 1107-1117 作者:  Yu, Lei;  Huang, Minhao;  Xu, Tianfeng;  Tong, Linjiang;  Yan, Xiao-e   |  收藏  |  浏览/下载：39/0  |  提交时间：2019/01/08 EGFR(T790M) mutant  Pyrido[2,3-d]pyrimidin-7-ones  Pharmacokinetic property  NSCLC  Irreversible inhibitor   Treating psoriasis by targeting its susceptibility gene Rel 期刊论文  OAI收割 CLINICAL IMMUNOLOGY, 2016 作者:  Fan, Tingting;  Wang, Shaowen;  Yu, Linjiang;  Yi, Hugiang;  Liu, Ruiling 收藏  |  浏览/下载：46/0  |  提交时间：2017/01/16 C5-substituted pyrido[2,3-d]pyrimidin-7-ones as highly specific kinase inhibitors targeting the clinical resistance-related EGFR(T790M) mutant 期刊论文  OAI收割 MEDCHEMCOMM, 2015, 卷号: 6, 期号: 9, 页码: 1693-1697 作者:  Ding, Ke;  Ren, Xiaomei;  Zhang, Lianwen;  Yu, Lei;  Luo, Jinfeng   |  收藏  |  浏览/下载：51/0  |  提交时间：2018/12/13 C5-substituted pyrido[2,3-d]pyrimidin-7-ones as highly specific kinase inhibitors targeting the clinical resistance-related EGFR(T790M) mutant 期刊论文  OAI收割 MEDCHEMCOMM, 2015, 卷号: 6, 期号: 9, 页码: 1693-1697 Xu, Tianfeng; Peng, Ting; Ren, Xiaomei; Zhang, Lianwen; Yu, Lei; Luo, Jinfeng; Zhang, Zhang; Tu, Zhengchao; Tong, Linjiang; Huang, Zhaoru; Lu, Xiaoyun; Geng, Meiyu; Xie, Hua; Ding, Jian; Ding, Ke 收藏  |  浏览/下载：71/0  |  提交时间：2016/12/16 C5-substituted pyrido[2,3-d]pyrimidin-7-ones as highly specific kinase inhibitors targeting the clinical resistance-related EGFR(T790M) mutant 期刊论文  OAI收割 MEDCHEMCOMM, 2015, 卷号: 6, 期号: 9, 页码: 1693-1697 作者:  Xu, Tianfeng;  Peng, Ting;  Ren, Xiaomei;  Zhang, Lianwen;  Yu, Lei   |  收藏  |  浏览/下载：45/0  |  提交时间：2019/01/08