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上海药物研究所 [35]
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期刊论文 [51]
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Design, synthesis of auristatins-glucuronide conjugates targeting the β-glucuronidase in tumor microenvironment
期刊论文
OAI收割
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2023, 卷号: 95, 页码: 5
作者:
Wang, Yujie
;
Xu, Keshi
;
Liu, Hongchun
;
Zhang, Wei
;
Hu, Chun
  |  
收藏
  |  
浏览/下载:22/0
  |  
提交时间:2023/12/19
Auristatin E
beta-Glucuronidase
Antiproliferation
Tumor microenvironment
Discovery of (S)-N-(2-Amino-4-fluorophenyl)-4-(1-(3-(4-((dimethylamino)methyl)phenyl)-6-oxopyridazin-1(6H)-yl)ethyl)benzamide as Potent Class I Selective HDAC Inhibitor for Oral Anticancer Drug Candidate
期刊论文
OAI收割
JOURNAL OF MEDICINAL CHEMISTRY, 2023, 卷号: 66, 期号: 10, 页码: 7016-7037
作者:
Li, Daqiang
;
Zhang, Zhuo
;
Li, Yalei
;
Wang, Xinyi
;
Zhong, Hanyue
  |  
收藏
  |  
浏览/下载:26/0
  |  
提交时间:2023/10/17
Effect of rubber substrates on the flexibility and tribological properties of diamond-like carbon coatings
期刊论文
OAI收割
Surface & Coatings Technology, 2021, 期号: 422, 页码: 127526
作者:
Yan Xu
;
Junhong Jia
;
Guangan Zhang
;
Hongchun Li
;
Tijun Chen
  |  
收藏
  |  
浏览/下载:27/0
  |  
提交时间:2021/12/08
Diamond-like carbon film
Rubber elastomers
Adhesion
Tribological property
Clerodenoids A-F: C-ring Aromatized and/or Rearranged Abietane Diterpenoids from Clerodendrum chinense var. simplex
期刊论文
OAI收割
CHINESE JOURNAL OF CHEMISTRY, 2021, 页码: 7
作者:
Qi, Jingjing
;
Zhang, Yan
;
Liu, Qunfang
;
Liu, Hongchun
;
Fan, Yaoyue
  |  
收藏
  |  
浏览/下载:39/0
  |  
提交时间:2021/08/17
Clerodendrum chinense
Natural products
Diterpenoids
Structural elucidation
Antiproliferative activities
A Neural-Network Based Spatial Resolution Downscaling Method for Soil Moisture: Case Study of Qinghai Province
期刊论文
OAI收割
REMOTE SENSING, 2021, 卷号: 13, 期号: 8, 页码: 22
作者:
Lv, Aifeng
;
Zhang, Zhilin
;
Zhu, Hongchun
  |  
收藏
  |  
浏览/下载:26/0
  |  
提交时间:2021/06/10
soil moisture
neural network
downscaling
microwave data
MODIS data
A Neural-Network Based Spatial Resolution Downscaling Method for Soil Moisture: Case Study of Qinghai Province
期刊论文
OAI收割
REMOTE SENSING, 2021, 卷号: 13, 期号: 8, 页码: 22
作者:
Lv, Aifeng
;
Zhang, Zhilin
;
Zhu, Hongchun
  |  
收藏
  |  
浏览/下载:20/0
  |  
提交时间:2021/06/10
soil moisture
neural network
downscaling
microwave data
MODIS data
Development of hedgehog pathway inhibitors by epigenetically targeting GLI through BET bromodomain for the treatment of medulloblastoma
期刊论文
OAI收割
ACTA PHARMACEUTICA SINICA B, 2021, 卷号: 11, 期号: 2, 页码: 488-504
作者:
Liu, Xiaohua
;
Zhang, Yu
;
Li, Yalei
;
Wang, Juan
;
Ding, Huaqian
  |  
收藏
  |  
浏览/下载:34/0
  |  
提交时间:2021/05/24
Medulloblastoma
Hedgehog signaling
pathway
Drug resistance
GLI
BRD4
Discovery of selective HDAC/BRD4 dual inhibitors as epigenetic probes
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 209, 页码: 20
作者:
Chen, Jingjing
;
Li, Yalei
;
Zhang, Jie
;
Zhang, Minmin
;
Wei, Aihuan
  |  
收藏
  |  
浏览/下载:76/0
  |  
提交时间:2021/05/24
HDAC
BRD4
Selective dual inhibitors
Anticancer
Synthesis and biological activity of C-7, C-9 and C-10 modified taxane analogues from 1-deoxybaccatin VI
期刊论文
OAI收割
BIOORGANIC & MEDICINAL CHEMISTRY, 2020, 卷号: 28, 期号: 21, 页码: 8
作者:
Xie, Chenghu
;
Cui, Yongmei
;
Li, Lanlan
;
Zhang, Minmin
;
Liu, Hongchun
  |  
收藏
  |  
浏览/下载:46/0
  |  
提交时间:2020/12/21
Paclitaxel
Taxane analogues
1-Deoxybaccatin VI
Synthesis
In vitro anticancer activity
Effects of Exogenous Organic Acids on Cd Tolerance Mechanism of Salix variegata Franch. Under Cd Stress
期刊论文
OAI收割
FRONTIERS IN PLANT SCIENCE, 2020, 卷号: 11, 页码: 13
作者:
Zhang, Songlin
;
Chen, Hongchun
;
He, Danni
;
He, Xinrui
;
Yan, Ya
  |  
收藏
  |  
浏览/下载:34/0
  |  
提交时间:2021/02/24
cadmium
Salix variegata
organic acid
antioxidant enzymatic system
non-protein sulfhydryl compounds
gene expression