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• 高能物理研究所 [167]
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• iSwitch采集 [168]
• OAI收割 [97]

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• 期刊论文 [265]

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• 2025 [3]
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浏览/检索结果: 共265条，第1-10条 帮助 条数/页： 5101520253035404550556065707580859095100 排序方式： 请选择题名升序题名降序提交时间升序提交时间降序作者升序作者降序发表日期升序发表日期降序 Discovery of novel covalent stabilizers for p53 Y220C using structure-based drug discovery methods 期刊论文  OAI收割 MOLECULAR DIVERSITY, 2025, 页码: 14 作者:  Wen, Yiming;  Xu, Peijia;  Chen, Yijie;  Meng, Jingyi;  Zheng, Mingyue   |  收藏  |  浏览/下载：7/0  |  提交时间：2025/04/01 p53 Y220C  Covalent stabilizer  Virtual screening  Molecular dynamics  DNA binding  Structure-activity relationship  Cancer therapy   Design, synthesis, and structure-activity relationship studies of triazolo-pyrimidine derivatives as WRN inhibitors for the treatment of MSI tumors 期刊论文  OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2025, 卷号: 282, 页码: 21 作者:  Sui, Qibang;  Zhou, Yuanyang;  Li, Manjia;  Wang, Dan;  Cui, Rongrong   |  收藏  |  浏览/下载：2/0  |  提交时间：2024/12/25 Synthetic lethal  MSI tumors  WRN inhibitors  Triazolo-pyrimidine derivatives   Mutation in CDC42 Gene Set as a Response Biomarker for Immune Checkpoint Inhibitor Therapy 期刊论文  OAI收割 CANCER MEDICINE, 2025, 卷号: 14, 期号: 1, 页码: 13 作者:  Wang, Kun;  Zhang, Yingying;  Su, Zhaoming;  Wang, Bei;  Zhou, Yuanyang   |  收藏  |  浏览/下载：5/0  |  提交时间：2025/04/01 biomarker  CDC42  clinical response  immunotherapy  pan-cancer   Age-related decline in CD8+ tissue resident memory T cells compromises antitumor immunity 期刊论文  OAI收割 NATURE AGING, 2024, 卷号: 4, 期号: 12, 页码: 1828-+ 作者:  Pei, Siyu;  Deng, Xiuyu;  Yang, Ruirui;  Wang, Hui;  Shi, Jian-Hong   |  收藏  |  浏览/下载：6/0  |  提交时间：2025/02/28 SurfDock is a surface-informed diffusion generative model for reliable and accurate protein-ligand complex prediction 期刊论文  OAI收割 NATURE METHODS, 2024, 页码: 24 作者:  Cao, Duanhua;  Chen, Mingan   |  收藏  |  浏览/下载：3/0  |  提交时间：2025/01/06 Ginkgetin Alleviates Inflammation and Senescence by Targeting STING 期刊论文  OAI收割 ADVANCED SCIENCE, 2024, 页码: 15 作者:  Liu, Yadan;  Ye, Jialin;  Fan, Zisheng;  Wu, Xiaolong;  Zhang, Yinghui   |  收藏  |  浏览/下载：9/0  |  提交时间：2024/12/16 cGAS-STING signaling  Ginkgetin  senescence  STING inhibitor  target identification   An updated patent review of SOS1 inhibitors (2022-present) 期刊论文  OAI收割 EXPERT OPINION ON THERAPEUTIC PATENTS, 2024, 页码: 15 作者:  Zhou, Guizhen;  Zhou, Chuan;  Ma, Xinyi;  Xu, Jiahang;  Zhou, Zehui   |  收藏  |  浏览/下载：3/0  |  提交时间：2024/12/11 SOS1  KRAS  cancer  inhibitor  drug discovery   Targeting STING oligomerization with licochalcone D ameliorates STING-driven inflammatory diseases 期刊论文  OAI收割 SCIENCE CHINA-LIFE SCIENCES, 2024, 页码: 14 作者:  Zhang, Yinghui;  Liu, Yadan;  Jiang, Bing;  Chen, Lifan;  Hu, Jie   |  收藏  |  浏览/下载：18/0  |  提交时间：2024/10/21 cGAS-STING signaling  STING inhibitor  TransformerCPI model  Licochalcone D  inflammatory diseases   Design, synthesis, and bioevaluation of SOS1 PROTACs derived from pyrido [2,3- d ]pyrimidin-7-one-based SOS1 inhibitor 期刊论文  OAI收割 BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2024, 卷号: 107, 页码: 9 作者:  Wang, Kun;  Zhou, Zehui;  Ma, Xinyi;  Xu, Jiahang;  Xu, Wangyang   |  收藏  |  浏览/下载：21/0  |  提交时间：2024/07/12 SOS1  KRAS mutation  PROTAC  Anti-cancer activity   Deep representation learning of chemical-induced transcriptional profile for phenotype-based drug discovery 期刊论文  OAI收割 NATURE COMMUNICATIONS, 2024, 卷号: 15, 期号: 1, 页码: 14 作者:  Tong, Xiaochu;  Qu, Ning;  Kong, Xiangtai;  Ni, Shengkun;  Zhou, Jingyi   |  收藏  |  浏览/下载：10/0  |  提交时间：2024/08/22