中国科学院机构知识库网格
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CAS IR Grid
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上海药物研究所 [65]
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The Forest Filter Effect vs. Cold Trapping Effect on the AltitudinalDistribution of PCBs: A Case Study of Mt. Gongga, Eastern Tibetan Plateau
期刊论文
OAI收割
出版物, 3111, 期号: 0, 页码: 1-32
作者:
Xin Liu
;
Jun Li
;
Qian Zheng
;
Haijian Bing
;
Ruijie Zhang
  |  
收藏
  |  
浏览/下载:370/0
  |  
提交时间:2017/07/24
Conformational restriction enables discovering a series of chroman derivatives as potent and selective NaV1.8 inhibitors with improved pharmacokinetic properties
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2025, 卷号: 293, 页码: 24
作者:
  |  
收藏
  |  
浏览/下载:1/0
  |  
提交时间:2025/08/20
Voltage-gated sodium channel 1.8
Conformational restriction
Pharmacokinetic
Structure-activity relationship
Analgesic
EP240801a/XRF 240801B: An X-Ray Flash Detected by the Einstein Probe and the Implications of Its Multiband Afterglow
期刊论文
OAI收割
ASTROPHYSICAL JOURNAL LETTERS, 2025, 卷号: 988, 期号: 1
作者:
Jiang, Shuai-Qing
;
Xu, Dong
;
Hoof, Agnes P. C. van
;
Lei, Wei-Hua
;
Liu, Yuan
  |  
收藏
  |  
浏览/下载:26/0
  |  
提交时间:2025/07/28
Discovery of 3-(Fluoro-imidazolyl)pyridazine Derivatives as Potent STING Agonists with Antitumor Activity
期刊论文
OAI收割
JOURNAL OF MEDICINAL CHEMISTRY, 2025, 卷号: 68, 期号: 10, 页码: 9864-9885
作者:
Hou, Hui
;
Zhou, Jingyi
;
Sui, Qibang
;
Zhang, Changfa
;
Su, Zhaoming
  |  
收藏
  |  
浏览/下载:11/0
  |  
提交时间:2025/07/25
Tailoring nanovectors for optimal neoantigen vaccine efficacy
期刊论文
OAI收割
JOURNAL OF MATERIALS CHEMISTRY B, 2025, 卷号: 13, 期号: 13, 页码: 4045-4058
作者:
Zheng, Youshi
;
Wang, Bing
;
Cai, Zhixiong
;
Lai, Zisen
;
Yu, Haijun
  |  
收藏
  |  
浏览/下载:11/0
  |  
提交时间:2025/04/24
An efficient deep learning-based strategy to screen inhibitors for GluN1/GluN3A receptor
期刊论文
OAI收割
ACTA PHARMACOLOGICA SINICA, 2025, 页码: 9
作者:
Wang, Ze-chen
;
Zeng, Yue
  |  
收藏
  |  
浏览/下载:13/0
  |  
提交时间:2025/04/24
deep learning
scoring function
GluN1/GluN3A receptor
N
-methyl-
D
-aspartate (NMDA) receptor
virtual screening
drug discovery
Terrestrial ecosystem response to Early Cretaceous global environmental change: A calibrated, high-resolution Aptian record from Northeast China
期刊论文
OAI收割
EARTH AND PLANETARY SCIENCE LETTERS, 2025, 卷号: 653, 页码: 13
作者:
Sun, Ming-Dao
;
Lin, Qin
;
Ramezani, Jahandar
;
Liu, Jiang-Si
;
Lu, Zheng-An
  |  
收藏
  |  
浏览/下载:46/0
  |  
提交时间:2025/04/03
Early Cretaceous
Aptian
CA-ID-TIMS geochronology
Astrochronology
Carbon isotope stratigraphy
Comparison of Hydraulic Fracturing and Deflagration Fracturing Under High-Temperature Conditions in Large-Sized Granite
期刊论文
OAI收割
APPLIED SCIENCES-BASEL, 2025, 卷号: 15, 期号: 5, 页码: 17
作者:
Yang, Hengtao
;
Zou, Yan
;
Bai, Bing
;
Ci, Huiling
;
Zhang, Tiancheng
  |  
收藏
  |  
浏览/下载:14/0
  |  
提交时间:2025/06/27
hydraulic fracturing
deflagration fracturing
high-temperature
large-sized model experiments
Study on Stability of Soil Slope in Seasonally Frozen Region Based on Water Transfer and Strength Deterioration under Freeze-Thaw Cycles
期刊论文
OAI收割
JOURNAL OF COLD REGIONS ENGINEERING, 2025, 卷号: 39, 期号: 1, 页码: 9
作者:
Zhan, Yongxiang
;
Zhao, Mingyang
;
Lan, Bing
;
Liu, Gang
;
Lu, Zheng
  |  
收藏
  |  
浏览/下载:11/0
  |  
提交时间:2025/06/27
Seasonally frozen soil region
Soil slope
Coupling water-heat migration
Freeze-thaw interface
Stability
π-HuB: the proteomic navigator of the human body
期刊论文
OAI收割
NATURE, 2024, 卷号: 636, 期号: 8042, 页码: 322-331
作者:
He, Fuchu
;
Aebersold, Ruedi
;
Baker, Mark S.
;
Bian, Xiuwu
;
Bo, Xiaochen
  |  
收藏
  |  
浏览/下载:45/0
  |  
提交时间:2025/04/01