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Discovery and Optimization of Novel Nonbile Acid FXR Agonists as Preclinical Candidates for the Treatment of Inflammatory Bowel Disease
期刊论文
OAI收割
JOURNAL OF MEDICINAL CHEMISTRY, 2024, 卷号: 67, 期号: 7, 页码: 5642-5661
作者:
Li, Yuan
;
Xu, Tingting
;
Zhao, Yue
;
Zhang, Hui
;
Liu, Zesheng
  |  
收藏
  |  
浏览/下载:3/0
  |  
提交时间:2024/05/07
Fucoxanthin Alleviates Dextran Sulfate Sodium-Induced Colitis and Gut Microbiota Dysbiosis in Mice
期刊论文
OAI收割
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2024, 卷号: 72, 期号: 8, 页码: 4142-4154
作者:
Yang, Yu-Hong
;
Chen, Chen
;
Zheng, Yan
;
Wu, Zi-Jian
;
Zhou, Meng-Qing
  |  
收藏
  |  
浏览/下载:23/0
  |  
提交时间:2024/04/07
fucoxanthin
colitis
intestinal barrier function
anti-inflammation
antioxidation
gut microbiota
The ALMA-QUARKS Survey. I. Survey Description and Data Reduction
期刊论文
OAI收割
RESEARCH IN ASTRONOMY AND ASTROPHYSICS, 2024, 卷号: 24, 期号: 2
作者:
Liu, Xunchuan
;
Liu, Tie
;
Zhu, Lei
;
Garay, Guido
;
Liu, Hong-Li
  |  
收藏
  |  
浏览/下载:6/0
  |  
提交时间:2024/03/29
stars: formation
stars: kinematics and dynamics
ISM: clouds
ISM: molecules
Np-Fe0 addition affects the microstructure and composition of the microwave-sintered lunar soil simulant CLRS-2
期刊论文
OAI收割
Advances in Space Research, 2024, 卷号: 73, 期号: 1, 页码: 945-957
作者:
Tian Zhang
;
Hong Tang
;
Xiongyao Li
;
Chuanjiao Zhou
;
Wen Yu
  |  
收藏
  |  
浏览/下载:12/0
  |  
提交时间:2024/03/14
Coexistence and Coevolution of Wrinkle and Ridge Patterns in the Film-Substrate System by Uniaxial Compression
期刊论文
OAI收割
LANGMUIR, 2023, 卷号: 40, 期号: 1, 页码: 403-412
作者:
Yu, Senjiang
;
Zhang, Jiahui
;
Zhou, Hong
;
Sun, Yadong
;
Ni Y(倪勇)
  |  
收藏
  |  
浏览/下载:4/0
  |  
提交时间:2024/02/05
Ecosystem responses dominate the trends of annual gross primary productivity over terrestrial ecosystems of China during 2000-2020
期刊论文
OAI收割
AGRICULTURAL AND FOREST METEOROLOGY, 2023, 卷号: 343, 页码: 109758
作者:
Zhu, Xian-Jin
;
Yu, Gui-Rui
;
Chen, Zhi
;
Zhang, Wei-Kang
;
Han, Lang
  |  
收藏
  |  
浏览/下载:13/0
  |  
提交时间:2023/12/04
Carbon cycles
Eddy covariance
Terrestrial ecosystems
Machine learning
Ecosystem responses
Substrate- and Catalyst-Controlled C-H Bond Activation/Annulation for Construction of Pyrido[2,3,4-
de
]quinazolinones and Indolo[1,2-
c
]quinazolinones
期刊论文
OAI收割
ADVANCED SYNTHESIS & CATALYSIS, 2023, 页码: 8
作者:
Hou, Xinjiao
;
Wang, Run
;
Zhou, Jianhui
;
Li, Yuan
;
Li, Jiyuan
  |  
收藏
  |  
浏览/下载:7/0
  |  
提交时间:2024/01/16
C-H bond activation
Fused heterocycles
Rh(III) catalysis
Ru(II) catalysis
A first-in-human phase 1 study of simnotrelvir, a 3CL-like protease inhibitor for treatment of COVID-19, in healthy adult subjects
期刊论文
OAI收割
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2023, 卷号: 191, 页码: 9
作者:
Yang, Xin-Mei
;
Yang, Yang
;
Yao, Bu-Fan
;
Ye, Pan-Pan
;
Xu, Yan
  |  
收藏
  |  
浏览/下载:11/0
  |  
提交时间:2023/12/11
COVID-19
Simnotrelvir
Safety
Pharmacokinetics
Healthy subjects
Structure-based drug discovery of novel fused- pyrazolone carboxamide derivatives as potent and selective AXL inhibitors
期刊论文
OAI收割
ACTA PHARMACEUTICA SINICA B, 2023, 卷号: 13, 期号: 12, 页码: 4918-4933
作者:
Fang, Feifei
;
Dai, Yang
;
Wang, Hao
;
Ji, Yinchun
;
Liang, Xuewu
  |  
收藏
  |  
浏览/下载:8/0
  |  
提交时间:2024/01/26
derivatives
Antitumor drug development
Potential AXL inhibitor
Antitumor activity
Structure-based drug design
Fused-pyrazolone carboxamide
Total synthesis of (±)-villosin C and (±)-teuvincenone B
期刊论文
OAI收割
ORGANIC CHEMISTRY FRONTIERS, 2023, 页码: 5
作者:
Zhou, Jin-Xin
;
Yan, Ming-Jie
;
Shi, Xiao-Yu
;
Wang, Yue-Qi
;
Shen, Hong-Yan
  |  
收藏
  |  
浏览/下载:26/0
  |  
提交时间:2024/01/16