中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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机构
上海生物化学与细胞... [12]
上海药物研究所 [10]
上海应用物理研究所 [9]
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期刊论文 [53]
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2023 [1]
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Pharmacological characterization of the small molecule 03A10 as an inhibitor of α-synuclein aggregation for Parkinson's disease treatment
期刊论文
OAI收割
ACTA PHARMACOLOGICA SINICA, 2023, 卷号: 44, 期号: 6, 页码: 1122-1134
作者:
Wang, Qing
;
Yao, Sheng
;
Yang, Ze-xian
;
Zhou, Chen
;
Zhang, Yu
  |  
收藏
  |  
浏览/下载:24/0
  |  
提交时间:2024/03/27
Parkinson's disease
alpha-synuclein aggregation
protein-protein interaction
03A10
MPTP/p model
enema inoculation model
MCC950 ameliorates the dementia symptom at the early age of line M83 mouse and reduces hippocampal alpha-synuclein accumulation
期刊论文
OAI收割
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2022, 卷号: 611, 页码: 23-30
作者:
Ren, Yu
;
Wang, Qing
;
Yang, Zexian
;
Feng, Linyin
;
Zhang, Yu
  |  
收藏
  |  
浏览/下载:33/0
  |  
提交时间:2022/11/11
MCC950
Line M83
Dementia
A53T alpha-synuclein
Autophagy
Metabolic Study of Stable Isotope Labeled Indolinone Derivative in Hepatocyte Cell by UPLC/Q TOF MS
期刊论文
OAI收割
JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY, 2021, 卷号: 32, 期号: 6, 页码: 1538-1544
作者:
Yang, Jixia
;
Zhang, Gongzheng
;
Wang, Zhaoyang
;
Meng, Jian
;
Wen, Hongliang
  |  
收藏
  |  
浏览/下载:39/0
  |  
提交时间:2021/12/16
indolinone derivatives
alpha-synuclein
[C-3(2), N-15]-isotope labeling, metabolite
UPLC/QTOF
Advances in the development of imaging probes and aggregation inhibitors for alpha-synuclein
期刊论文
OAI收割
ACTA PHARMACOLOGICA SINICA, 2020, 卷号: 41, 期号: 4, 页码: 483-498
作者:
Xu, Ming-ming
;
Ryan, Philip
;
Rudrawar, Santosh
;
Quinn, Ronald J.
;
Zhang, Hai-yan
  |  
收藏
  |  
浏览/下载:34/0
  |  
提交时间:2020/07/01
Parkinson's disease
alpha-synuclein
imaging probes
aggregation inhibitors
thioflavin-T
mass spectrometry
Identification of a New alpha-Synuclein Aggregation Inhibitor via Mass Spectrometry Based Screening
期刊论文
OAI收割
ACS CHEMICAL NEUROSCIENCE, 2019, 卷号: 10, 期号: 6, 页码: 2683-2691
作者:
Xu, Mingming
;
Loa-Kum-Cheung, Wendy
;
Zhang, Haiyan
;
Quinn, Ronald J.
;
Mellick, George D.
  |  
收藏
  |  
浏览/下载:18/0
  |  
提交时间:2020/07/01
Parkinson's disease
alpha-synuclein
aggregation
mass spectrometry
screening
inhibitor
Naturally occurring autoantibodies against alpha-synuclein rescues memory and motor deficits and attenuates alpha-synuclein pathology in mouse model of Parkinson's disease
期刊论文
OAI收割
NEUROBIOLOGY OF DISEASE, 2019, 卷号: 124, 页码: 202-217
作者:
Huang, Ya-ru
;
Xie, Xi-xiu
;
Ji, Mei
;
Yu, Xiao-lin
;
Zhu, Jie
  |  
收藏
  |  
浏览/下载:86/0
  |  
提交时间:2019/04/03
Parkinson's disease
alpha-Synuclein
Naturally occurring autoantibodies
A53T mice
WIG
Calcium accelerates SNARE-mediated lipid mixing through modulating alpha-synuclein membrane interaction
期刊论文
OAI收割
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES, 2018, 卷号: 1860, 期号: 9, 页码: 1848-1853
作者:
Zhang, Zeting
;
Jiang, Xin
;
Xu, Danrui
;
Zheng, Wenwen
;
Liu, Maili
  |  
收藏
  |  
浏览/下载:32/0
  |  
提交时间:2018/11/05
Alpha-synuclein
Ca2++
Nmr Spectroscopy
Membrane Binding
Snare-mediated Membrane Fusion
Cell-addictive dual-target traceable nanodrug for Parkinson's disease treatment via flotillins pathway
期刊论文
OAI收割
THERANOSTICS, 2018, 卷号: 8, 期号: 19, 页码: 5469
作者:
Li, YH
;
Chen, ZX
;
Lu, ZG
;
Yang, QH
;
Liu, LY
  |  
收藏
  |  
浏览/下载:56/0
  |  
提交时间:2018/12/29
Parkinson's Disease
Blood-brain-barrier
Dopaminergic Neurons
Cocaine Binding-site
Egcg
Alpha-synuclein
Nanoparticles
Dopamine Transporter
Alpha-synclein Aggregation
Laminin Receptor
Tea Polyphenol
Potential Inhibitors
Alzheimers-disease
Mazindol Analogs
Delivery
PolyQ-expanded huntingtin and ataxin-3 sequester ubiquitin adaptors hHR23B and UBQLN2 into aggregates via conjugated ubiquitin
期刊论文
OAI收割
FASEB JOURNAL, 2018, 卷号: 32, 期号: 6, 页码: 2923-2933
作者:
Yang, Hui
;
Yue, Hong-Wei
;
He, Wen-Tian
;
Hong, Jun-Ye
;
Jiang, Lei-Lei
  |  
收藏
  |  
浏览/下载:30/0
  |  
提交时间:2019/04/28
Protein-quality Control
Group-c Protein
Polyglutamine Disease
Alpha-synuclein
Neurodegenerative Diseases
Parkinsons-disease
Nuclear Inclusions
Nucleocytoplasmic Transport
Deubiquitinating Function
Cytoplasmic Inclusions
Structural changes of gut microbiota in Parkinson's disease and its correlation with clinical features
期刊论文
OAI收割
SCIENCE CHINA-LIFE SCIENCES, 2017, 卷号: 60, 期号: 11, 页码: 1223-1233
作者:
Li, Wei
;
Wu, Xiaoli
;
Hu, Xu
;
Wang, Tao
;
Liang, Shan
  |  
收藏
  |  
浏览/下载:43/0
  |  
提交时间:2018/05/28
microbiome
alpha-synuclein
gastrointestinal dysfunction
gut-brain-axis
16S rRNA sequencing
short chain fatty acids