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• 大连化学物理研究所 [79]
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浏览/检索结果: 共468条，第1-10条 帮助 条数/页： 5101520253035404550556065707580859095100 排序方式： 请选择题名升序题名降序发表日期升序发表日期降序提交时间升序提交时间降序作者升序作者降序 Design, synthesis, and evaluation of Menin-targeting compounds for the treatment of acute Myelocytic leukemia (AML) 期刊论文  OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2025, 卷号: 296, 页码: 17 作者:  Mo, Jun;  Wang, Yuxian;  Pan, Youlu;  Xiao, Qitao;  Zhao, Jinyi   |  收藏  |  浏览/下载：23/0  |  提交时间：2025/08/20 Menin  High binding affinity  Anti-proliferation activity  AML   Contrastive learning-based drug screening model for GluN1/GluN3A inhibitors 期刊论文  OAI收割 ACTA PHARMACOLOGICA SINICA, 2025, 页码: 13 作者:  Li, Kun;  Zeng, Yue;  Xiong, Yi-da;  Wu, Hao-chen;  Fang, Sui   |  收藏  |  浏览/下载：25/0  |  提交时间：2025/08/20 drug-target affinity prediction  virtual screening  contrastive learning  graph neural network  N-methyl-D-aspartate (NMDA) receptors  GluN3A subunit.   Enhanced antibody-mediated cellular cytotoxicity of germline-like anti-HER2 antibodies through a point mutation in complementarity-determining regions 期刊论文  OAI收割 JOURNAL OF IMMUNOLOGY, 2025, 页码: 11 作者:  Zhou, Guangyu;  Zhang, Yunsen;  Gu, Yuheng;  Cao, Bihui;  Fan, Xin   |  收藏  |  浏览/下载：35/0  |  提交时间：2025/06/23 affinity maturation  antibody-mediated cellular cytotoxicity  gremlin-like antibody  HER2  in silicon   Online bioactivity-guided HPLC-lipoprotein lipase system with medium-high pressure chromatography for rapid recognition and targeted isolation of natural affinity agents from Nitraria tangutorum 期刊论文  OAI收割 JOURNAL OF CHROMATOGRAPHY A, 2025, 卷号: 1762 作者:  Wu, Qianyu;  Zhang, Yu;  Sun, Ce;  Dang, Jun   |  收藏  |  浏览/下载：5/0  |  提交时间：2025/11/27 Nitraria tangutorum  Online HPLC-lipoprotein lipase system  Lipoprotein lipase active chromatographic peak recognition  Medium-high pressure liquid chromatography  Lipoprotein lipase affinity agents   Drug Target Investigation of N-p-Coumaroyl-N'-Caffeoylputrescine, a Naturally-Occurring Alkaloid Derived from Saxifraga tangutica 期刊论文  OAI收割 ANTIOXIDANTS, 2025, 卷号: 14, 期号: 1 作者:  Liu, Chuang;  Dang, Jun;  Wu, Minchen   |  收藏  |  浏览/下载：11/0  |  提交时间：2025/11/27 Saxifraga tangutica  N-p-coumaroyl-N'-caffeoylputrescine  drug affinity responsive target stability  reverse virtual docking  molecular dynamics simulation   Interaction-Based Inductive Bias in Graph Neural Networks: Enhancing Protein-Ligand Binding Affinity Predictions From 3D Structures 期刊论文  OAI收割 IEEE TRANSACTIONS ON PATTERN ANALYSIS AND MACHINE INTELLIGENCE, 2024, 卷号: 46, 期号: 12, 页码: 8191-8208 作者:  Yang, Ziduo   |  收藏  |  浏览/下载：48/0  |  提交时间：2025/01/14 Proteins  Programmable logic arrays  Three-dimensional displays  Predictive models  Graph neural networks  Data models  Convolution  Protein-ligand binding affinity  graph neural networks  inductive bias  drug-target interaction  structure-based virtual screening   Photo-induced protonation assisted nano primary battery for highly efficient immobilization of diverse heavy metal ions 期刊论文  OAI收割 JOURNAL OF HAZARDOUS MATERIALS, 2024, 卷号: 476 作者:  Ge, Hongjian;  Chen, Chaowen;  Li, Sijia;  Guo, Xinyue;  Zhang, Jing   |  收藏  |  浏览/下载：30/0  |  提交时间：2024/11/22 Multi heavy metal ions immobilization  Photo -induced protonation  Enhanced affinity  Fast electrons transfer   Design and synthesis of novel site-specific antibody-drug conjugates that target TROP2 期刊论文  OAI收割 BIOORGANIC & MEDICINAL CHEMISTRY, 2024, 卷号: 110, 页码: 16 作者:  Luo, Caili;  Ren, Anni;  Jin, Zixuan;  Zhang, Jianxin;  Shi, Wei   |  收藏  |  浏览/下载：39/0  |  提交时间：2024/08/22 TROP2  Antibody-drug conjugate (ADC)  Site-specific  Glycoengineering  Affinity-directed conjugation   Ultrathin Flexible Silica Nanosheets with Surface Chemistry-Modulated Affinity to Mammalian Cells 期刊论文  OAI收割 SMALL, 2024, 页码: 12 作者:  Wang, Jie;  Li, Ping;  Zhang, Renshuai;  Zhang, Miao;  Wang, Chao   |  收藏  |  浏览/下载：27/0  |  提交时间：2024/09/02 coarse grained molecular dynamics  flexibility  nanoparticle-cell affinity  surface chemistry  ultrathin silica nanosheets   A Novel Strategy for Automatic Selection of Cross-Basin Data to Improve Local Machine Learning-Based Runoff Models 期刊论文  OAI收割 WATER RESOURCES RESEARCH, 2024, 卷号: 60, 期号: 5, 页码: e2023WR035051 作者:     |  收藏  |  浏览/下载：42/0  |  提交时间：2024/06/17 LSTM  deep learning  basin-affinity  data selection