中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
机构
采集方式
内容类型
发表日期
学科主题
筛选

浏览/检索结果: 共6条,第1-6条 帮助

条数/页: 排序方式:
Methanolic extract of Cariniana rubra Gardner ex Miers stem bark negatively regulate the leukocyte migration and TNF-alpha and up-regulate the annexin-A1 expression 期刊论文  OAI收割
JOURNAL OF ETHNOPHARMACOLOGY, 2021, 卷号: 270, 页码: 113778
作者:  
Paulino Brandao Silva,Donata Norman;  Adriana,Flach;  de Oliveira Martins,Domingos Tabajara;  Borges,Quessi Irias;  Nunes Lindote,Marcus Vitor
  |  收藏  |  浏览/下载:69/0  |  提交时间:2022/04/02
Apoptosis induction and G2/M arrest of 2-methyl-1,3,6-trihydroxy-9,10-anthraquinone from Rubia yunnanensis in human cervical cancer HeLa cells 期刊论文  OAI收割
PHARMAZIE, 2013, 卷号: 68, 期号: 4, 页码: 293-299
作者:  
Zeng, Guang-Zhi;  Fan, Jun-Ting;  Xu, Jun-Ju;  Li, Yan;  Tan, Ning-Hua
收藏  |  浏览/下载:40/0  |  提交时间:2015/05/14
2-Methyl-1,3,6-trihydroxy-9,10-anthraquinone (MTA)  one of the major components isolated from the traditional  Chinese medicine Rubia yunnanensis  exhibited inhibitory activity on the proliferation of several  human cancer cell lines. The results from an annexin V-FITC (fluoresein-5-isothiocyanate) apoptosis assay  and DNA content analysis showed that MTA exerted cytotoxicity via apoptosis induction and G2/M cell cycle  arrest in human cervical carcinoma HeLa cells. Further  MTA was found to induce apoptosis of HeLa cells  through the mitochondria-mediated pathway. It caused the translocation of Bax to the mitochondria and  release of cytochrome c into the cytosol  which caused the cleavage of caspase and poly(ADP-ribose)  polymerase and finally triggered the apoptosis. Furthermore  the p53/p21/Cdc2-cyclin B1 signaling was  found related to the G2/M arrest caused by MTA. The over-expression of p21 and down-expression of  cyclin B1 caused by MTA inactivated the Cdc2-cyclin B1 complex of G2/M checkpoint and finally caused  the G2/M arrest in HeLa cells. This study demonstrated that MTA is a potential anti-cancer component of  R. yunnanensis  a folk anti-cancer herb used in Yunnan  China.  
A novel annexin A2 protein with platelet aggregation-inhibiting activity from amphibian Bombina maxima skin 期刊论文  OAI收割
TOXICON, 2010, 卷号: 56, 期号: 3, 页码: 458-465
作者:  
Zhang Y;  Yu GY;  Lee WH;  Zhang Y[*];  Wang YJ
收藏  |  浏览/下载:16/0  |  提交时间:2016/03/24
Comparative proteomic analysis to discover potential therapeutic targets in human multiple myeloma 期刊论文  iSwitch采集
Proteomics clinical applications, 2009, 卷号: 3, 期号: 11, 页码: 1348-1360
作者:  
Xiao, Chuan-Le;  Zhang, Zhi-Ping;  Xiong, Sheng;  Lu, Chun-Hua;  Wei, Hong-Ping
收藏  |  浏览/下载:26/0  |  提交时间:2019/05/09
Effects of subretinal implant materials on the viability, apoptosis and barrier function of cultured RPE cells 期刊论文  OAI收割
graefes archive for clinical and experimental ophthalmology, 2007, 卷号: 245, 期号: 1, 页码: 135-142
Wu HJ (Wu Hui-Juan); Li XX (Li Xiao-Xin); Dong JQ (Dong Jian-Qiang); Pei WH (Pei Wei-Hua); Chen HD (Chen Hong-Da)
收藏  |  浏览/下载:42/0  |  提交时间:2010/04/11
Expression and secretion of functional recombinant(1) scu-PA : AV in insect cell using signal peptides 期刊论文  OAI收割
PROTEIN AND PEPTIDE LETTERS, 2004, 卷号: 11, 期号: 1, 页码: 49-55
作者:  
Huang, YH;  Tian, RY;  Hu, W;  Wu, XF;  Yang, SL
收藏  |  浏览/下载:25/0  |  提交时间:2015/07/22