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昆明植物研究所 [2]
武汉病毒研究所 [1]
上海生物化学与细胞生... [1]
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昆明动物研究所 [1]
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期刊论文 [6]
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Methanolic extract of Cariniana rubra Gardner ex Miers stem bark negatively regulate the leukocyte migration and TNF-alpha and up-regulate the annexin-A1 expression
期刊论文
OAI收割
JOURNAL OF ETHNOPHARMACOLOGY, 2021, 卷号: 270, 页码: 113778
作者:
Paulino Brandao Silva,Donata Norman
;
Adriana,Flach
;
de Oliveira Martins,Domingos Tabajara
;
Borges,Quessi Irias
;
Nunes Lindote,Marcus Vitor
  |  
收藏
  |  
浏览/下载:69/0
  |  
提交时间:2022/04/02
Cariniana rubra, anti-inflammatory
Air pouch
TNF-alpha
Annexin A1
Gallic acid
Terpenes
Mice
GENE-EXPRESSION
INFLAMMATION
Apoptosis induction and G2/M arrest of 2-methyl-1,3,6-trihydroxy-9,10-anthraquinone from Rubia yunnanensis in human cervical cancer HeLa cells
期刊论文
OAI收割
PHARMAZIE, 2013, 卷号: 68, 期号: 4, 页码: 293-299
作者:
Zeng, Guang-Zhi
;
Fan, Jun-Ting
;
Xu, Jun-Ju
;
Li, Yan
;
Tan, Ning-Hua
收藏
  |  
浏览/下载:40/0
  |  
提交时间:2015/05/14
2-Methyl-1,3,6-trihydroxy-9,10-anthraquinone (MTA)
one of the major components isolated from the traditional
Chinese medicine Rubia yunnanensis
exhibited inhibitory activity on the proliferation of several
human cancer cell lines. The results from an annexin V-FITC (fluoresein-5-isothiocyanate) apoptosis assay
and DNA content analysis showed that MTA exerted cytotoxicity via apoptosis induction and G2/M cell cycle
arrest in human cervical carcinoma HeLa cells. Further
MTA was found to induce apoptosis of HeLa cells
through the mitochondria-mediated pathway. It caused the translocation of Bax to the mitochondria and
release of cytochrome c into the cytosol
which caused the cleavage of caspase and poly(ADP-ribose)
polymerase and finally triggered the apoptosis. Furthermore
the p53/p21/Cdc2-cyclin B1 signaling was
found related to the G2/M arrest caused by MTA. The over-expression of p21 and down-expression of
cyclin B1 caused by MTA inactivated the Cdc2-cyclin B1 complex of G2/M checkpoint and finally caused
the G2/M arrest in HeLa cells. This study demonstrated that MTA is a potential anti-cancer component of
R. yunnanensis
a folk anti-cancer herb used in Yunnan
China.
A novel annexin A2 protein with platelet aggregation-inhibiting activity from amphibian Bombina maxima skin
期刊论文
OAI收割
TOXICON, 2010, 卷号: 56, 期号: 3, 页码: 458-465
作者:
Zhang Y
;
Yu GY
;
Lee WH
;
Zhang Y[*]
;
Wang YJ
收藏
  |  
浏览/下载:16/0
  |  
提交时间:2016/03/24
Amphibian
Skin
Annexin
Platelet activation
Comparative proteomic analysis to discover potential therapeutic targets in human multiple myeloma
期刊论文
iSwitch采集
Proteomics clinical applications, 2009, 卷号: 3, 期号: 11, 页码: 1348-1360
作者:
Xiao, Chuan-Le
;
Zhang, Zhi-Ping
;
Xiong, Sheng
;
Lu, Chun-Hua
;
Wei, Hong-Ping
收藏
  |  
浏览/下载:26/0
  |  
提交时间:2019/05/09
Annexin a1
Multiple myeloma
Plasma cell
Effects of subretinal implant materials on the viability, apoptosis and barrier function of cultured RPE cells
期刊论文
OAI收割
graefes archive for clinical and experimental ophthalmology, 2007, 卷号: 245, 期号: 1, 页码: 135-142
Wu HJ (Wu Hui-Juan)
;
Li XX (Li Xiao-Xin)
;
Dong JQ (Dong Jian-Qiang)
;
Pei WH (Pei Wei-Hua)
;
Chen HD (Chen Hong-Da)
收藏
  |  
浏览/下载:42/0
  |  
提交时间:2010/04/11
retinal pigment epithelium (RPE)
subretinal microphotodiode array (MPDA)
biocompatibility
primary culture
microporous filter
PIGMENT EPITHELIAL-CELLS
ANNEXIN-V
EXPRESSION
ARPE-19
LINE
Expression and secretion of functional recombinant(1) scu-PA : AV in insect cell using signal peptides
期刊论文
OAI收割
PROTEIN AND PEPTIDE LETTERS, 2004, 卷号: 11, 期号: 1, 页码: 49-55
作者:
Huang, YH
;
Tian, RY
;
Hu, W
;
Wu, XF
;
Yang, SL
收藏
  |  
浏览/下载:25/0
  |  
提交时间:2015/07/22
protein expression
signal peptide
baculovirus-insect cell system
annexin V
low molecular weight urokinase