机构

• 上海药物研究所 [20]
• 昆明植物研究所 [4]
• 金属研究所 [2]
• 中国科学院大学 [2]
• 生物物理研究所 [1]
• 上海神经科学研究所 [1]
• 更多

采集方式

• OAI收割 [30]
• iSwitch采集 [2]

内容类型

• 期刊论文 [32]

发表日期

• 2023 [1]
• 2021 [1]
• 2019 [1]
• 2018 [3]
• 2017 [6]
• 2016 [4]
• 更多

学科主题

• Biochemist... [2]
• Chemistry [1]
• Neuroscien... [1]
• Pharmacolo... [1]

筛选

浏览/检索结果: 共32条，第1-10条 帮助 条数/页： 5101520253035404550556065707580859095100 排序方式： 请选择题名升序题名降序提交时间升序提交时间降序作者升序作者降序发表日期升序发表日期降序 ARL6IP1 mediates small-molecule-induced alleviation of Alzheimer pathology through FXR1-dependent BACE1 translation initiation 期刊论文  OAI收割 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2023, 卷号: 120, 期号: 22, 页码: e2220148120 作者:  Zhou,Gui-Feng;  Tang,Jing;  Ma,Yuan-Lin;  Fu,Xian;  Liu,Jun-Yan   |  收藏  |  浏览/下载：16/0  |  提交时间：2024/05/09 conophylline  ARL6IP1  5'UTR  FXR1  BACE1 translation  AMYLOID PRECURSOR PROTEIN  A-BETA  TRANSGENIC MICE  MOUSE MODEL  NEURODEGENERATION  EXPRESSION  REDUCTION  MEMBRANE  MEMORY  ER   Unprecedented polycyclic polyprenylated acylphloroglucinols with anti-Alzheimer's activity from St. John's wort 期刊论文  OAI收割 CHEMICAL SCIENCE, 2021, 卷号: 12, 期号: 34, 页码: 11438-11446 作者:  Guo,Yi;  Huang,Fang;  Sun,Weiguang;  Zhou,Yuan   |  收藏  |  浏览/下载：32/0  |  提交时间：2022/04/02 AMYLOID-BETA  NEUROFIBRILLARY DEGENERATION  HYPERFORIN  NEUROTOXICITY  PATHOGENESIS  INHIBITION  BACE1  DRUG  TAU   Structure-Based Survey of the Binding Modes of BACE1 Inhibitors 期刊论文  OAI收割 ACS CHEMICAL NEUROSCIENCE, 2019, 卷号: 10, 期号: 2, 页码: 880-889 作者:  Hu, Hangchen;  Chen, Zhaoqiang;  Xu, Xiang;  Xuo, Yechun   |  收藏  |  浏览/下载：19/0  |  提交时间：2020/07/01 BACE1  Alzheimer's disease  inhibitor  ligand binding mode  subsite  substructure   Protopanaxadiol derivative DDPU improves behavior and cognitive deficit in AD mice involving regulation of both ER stress and autophagy 期刊论文  OAI收割 NEUROPHARMACOLOGY, 2018, 卷号: 130, 页码: 77-91 作者:  Guo, Xiaodan;  Lv, Jianlu;  Lu, Jian;  Fan, Lei;  Huang, Xi   |  收藏  |  浏览/下载：66/0  |  提交时间：2019/01/08 Alzheimer's disease  Ginseng  Autophagy  BACE1  ER stress  Amyloid beta  Apoptosis  APP/PS1 transgenic mice   Visualization of Alzheimer's Disease Related alpha-/beta-/gamma-Secretase Ternary Complex by Bimolecular Fluorescence Complementation Based Fluorescence Resonance Energy Transfer 期刊论文  OAI收割 FRONTIERS IN MOLECULAR NEUROSCIENCE, 2018, 卷号: 11, 期号: 1, 页码: 431 作者:  Wang, Xin;  Pei, Gang   |  收藏  |  浏览/下载：29/0  |  提交时间：2019/04/28 Amyloid Precursor Protein  Beta-secretase  App  Site  Cleavage  Adam10  Bace1  Localization  Dimerization  Endocytosis   Effect of microenvironment on beta-site amyloid precursor protein cleaving enzyme 1 expression in PC12 Cells 期刊论文  OAI收割 Journal of Shanghai Jiaotong University .Medical Science, 2018, 卷号: 38, 期号: 9, 页码: 1005-1012 作者:  Yang Huanqing;  He Xiang;  Du Xiaoguang;  Xiao Shifu;  Wang Tao   |  收藏  |  浏览/下载：139/0  |  提交时间：2019/01/08 Alzheimer's disease  microenvironment  PC12 cell  beta-site amyloid precursor protein cleaving enzyme 1 (BACE1)  amyloid-beta peptide (Abeta)   Comparative QSAR studies using HQSAR, CoMFA, and CoMSIA methods on cyclic sulfone hydroxyethylamines as BACE1 inhibitors 期刊论文  OAI收割 COMPUTATIONAL BIOLOGY AND CHEMISTRY, 2017, 卷号: 67, 期号: 1, 页码: 38-47 作者:  Zhang, Shuqun;  Lin, Zichun;  Pu, Yinglan;  Zhang, Yunqin;  Zhang, Li 收藏  |  浏览/下载：35/0  |  提交时间：2017/05/19 BACE1  AD  HQSAR  CoMFA  CoMSIA   Comparative QSAR studies using HQSAR, CoMFA, and CoMSIA methods on cyclic sulfone hydroxyethylamines as BACE1 inhibitors 期刊论文  OAI收割 COMPUTATIONAL BIOLOGY AND CHEMISTRY, 2017, 卷号: 67, 页码: 38-47 作者:  Zhang, Shuqun;  Lin, Zichun;  Pu, Yinglan;  Zhang, Yunqin;  Zhang, Li   |  收藏  |  浏览/下载：32/0  |  提交时间：2019/01/08 BACE1  AD  HQSAR  CoMFA  CoMSIA   Synthetic Analogues of Betulinic Acid as Potent Inhibitors of PS1/BACE1 Interaction to Reduce A Generation 期刊论文  OAI收割 CHINESE JOURNAL OF CHEMISTRY, 2017, 卷号: 35, 期号: 1, 页码: 103-112 作者:  Zhang, Chenlu;  Wang, Xiaoyin;  Cui, Jin;  Li, Xiaohang;  Zhang, Yangming   |  收藏  |  浏览/下载：30/0  |  提交时间：2019/01/08 Alzheimer's disease  PS1  BACE1 interaction  A  betulinic acid  SAR   Thamnolia vermicularis extract improves learning ability in APP/PS1 transgenic mice by ameliorating both A beta and Tau pathologies 期刊论文  OAI收割 ACTA PHARMACOLOGICA SINICA, 2017, 卷号: 38, 期号: 1, 页码: 9-28 作者:  Li, Cong;  Gu, Xiao-dan;  Lei, Min;  Wu, Jia-yi;  Jin, Jia-zhen   |  收藏  |  浏览/下载：36/0  |  提交时间：2019/01/08 Alzheimer's disease  Thamnolia vermicularis  SH-SY5Y cells  APP/PS1 transgenic mice  senile plaque  cognition  amyloid-beta  Tau  autophagy  BACE1  GSK3 beta  PI3K