中国科学院机构知识库网格系统: 检索

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	Discovery and synthesis of 6,7,8,9-tetrahydro-5H-pyrido[4,3-c]azepin-5-one-based novel chemotype CCR2 antagonists via scaffold hopping strategy 期刊论文 OAI收割 BIOORGANIC & MEDICINAL CHEMISTRY, 2018, 卷号: 26, 期号: 12, 页码: 3559-3572 作者: Qin, Li-Huai; Wang, Zhi-Long; Xie, Xin; Long, Ya-Qiu \| 收藏 \| 浏览/下载：42/0 \| 提交时间：2019/01/08 6,7,8,9-Tetrahydro-5H-pyrido[43-c]azepin-5-one 3,4-Dihydro-2,6-naphthyridin-1(2H)-one CCR2 antagonist Scaffold hopping Structure-activity relationship Selectivity of CCR2 over CCR5
	化合物DC521018和hop-8体外抗HIV活性及作用机制研究学位论文 OAI收割北京: 中国科学院大学, 2018 作者: 陈欢 \| 收藏 \| 浏览/下载：43/0 \| 提交时间：2019/09/06 抗hiv活性,12-o-tricosanoylphorbol-20-acetate,Ccr5拮抗剂,临床前药效学评价,Apobec3g 12-o-tricosanoylphorbol-20-acetate Ccr5 Antagonist Preclinical Pharmacodynamic Apobec3g Ant-hiv Activity
	Design, synthesis, and biological evaluation of novel 2-methylpiperazine derivatives as potent CCR5 antagonists 期刊论文 OAI收割 BIOORGANIC & MEDICINAL CHEMISTRY, 2015, 卷号: 23, 期号: 5, 页码: 1157-1168 作者: Hu, Suwen; Wang, Zhilong; Hou, Tingjun; Ma, Xiaodong; Li, Jing \| 收藏 \| 浏览/下载：29/0 \| 提交时间：2019/01/08 CCR5 antagonist Anti-HIV-1 agent 2-Methylpiperazine derivatives
	Studies on the structure-activity relationship of 1,3,3,4-tetra-substituted pyrrolidine embodied CCR5 receptor antagonists. Part 2: Discovery of highly potent anti-HIV agents 期刊论文 OAI收割 BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2010, 卷号: 20, 期号: 17, 页码: 5334-5336 作者: Li, Ben; Jones, Eric Dale; Zhou, Enkun; Chen, Li; Baylis, Dean Cameron \| 收藏 \| 浏览/下载：26/0 \| 提交时间：2019/01/08 CCR5 receptor antagonist Anti-HIV
	Efficient synthesis and identification of novel propane-1,3-diamino bridged CCR5 antagonists with variation on the basic center carrier 期刊论文 OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2010, 卷号: 45, 期号: 7, 页码: 2827-2840 作者: Fan, Xing; Zhang, Hu-Shan; Chen, Li; Long, Ya-Qiu \| 收藏 \| 浏览/下载：18/0 \| 提交时间：2019/01/08 CCR5 antagonist Propane-1,3-diamine Convergent synthesis (S)-beta-amino-beta-arylpropanal 4-Amino-4-methylpiperidine Basic center carrier
	Discovery of novel (S)-alpha-phenyl-gamma-amino butanamide containing CCR5 antagonists via functionality inversion approach 期刊论文 OAI收割 BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2010, 卷号: 20, 期号: 7, 页码: 2219-2223 作者: Zhang, Hu-Shan; Feng, Dong-Zhi; Chen, Li; Long, Ya-Qiu \| 收藏 \| 浏览/下载：17/0 \| 提交时间：2019/01/08 CCR5 antagonist HIV-1 entry inhibitor Functionality inversion Bioisostere Butanamide Tropane 2-Methyl-3H-imidazo[4,5-b]pyridine 3H-[1,2,3]Triazolo[4,5-b]pyridine
	Discovery of a Novel CCR5 Antagonist Lead Compound Through Fragment Assembly 期刊论文 OAI收割 MOLECULES, 2008, 卷号: 13, 期号: 10, 页码: 2426-2441 作者: Liu, Yanqing; Zhou, Enkun; Yu, Kunqian; Zhu, Jin; Zhang, Yu \| 收藏 \| 浏览/下载：27/0 \| 提交时间：2019/01/08 CCR5 antagonist fragment assembly HIV-1 molecular modeling
	An improved synthesis of piperazino-piperidine based CCR5 antagonists with flexible variation on pharmacophore sites 期刊论文 OAI收割 TETRAHEDRON, 2005, 卷号: 61, 期号: 5, 页码: 1281-1288 作者: Jiang, XH; Song, YL; Feng, DZ; Long, YQ \| 收藏 \| 浏览/下载：17/0 \| 提交时间：2019/01/08 piperazino-piperidine nucleus CCR5 antagonist reductive amination chiral pool 4-substituent-4-aminopiperidine
	Facile synthesis of 4-substituted-4-aminopiperidine derivatives, the key building block of piperazine-based CCR5 antagonists 期刊论文 OAI收割 BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2004, 卷号: 14, 期号: 14, 页码: 3675-3678 作者: Jiang, XH; Song, YL; Long, YQ \| 收藏 \| 浏览/下载：17/0 \| 提交时间：2019/01/08 4-substituted-4-aminopiperidine piperazine-based CCR5 antagonist curtius rearrangement building block convergent synthesis HIV-1 entry inhibitor