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Therapeutic potential and pharmacological mechanisms of Traditional Chinese Medicine in gout treatment 期刊论文  OAI收割
ACTA PHARMACOLOGICA SINICA, 2025, 页码: 21
作者:  
Guo, Jing-wen
  |  收藏  |  浏览/下载:11/0  |  提交时间:2025/04/01
Dual-channel hypergraph convolutional network for predicting herb-disease associations 期刊论文  OAI收割
BRIEFINGS IN BIOINFORMATICS, 2024, 卷号: 25, 期号: 2, 页码: 13
作者:  
Hu, Lun;  Zhang, Menglong;  Hu, Pengwei;  Zhang, Jun;  Niu, Chao
  |  收藏  |  浏览/下载:10/0  |  提交时间:2024/08/22
Astragalus membranaceus root supplementation improves average daily gain, rumen fermentation, serum immunity and antioxidant indices of Tibetan sheep 期刊论文  OAI收割
ANIMAL, 2021, 卷号: 15, 期号: 1
作者:  
  |  收藏  |  浏览/下载:83/0  |  提交时间:2021/11/18
Artemicapillasins A-N, cytotoxic coumaric acid analogues against hepatic stellate cell LX2 from Artemisia capillaris (Yin-Chen) 期刊论文  OAI收割
BIOORGANIC CHEMISTRY, 2021, 卷号: 117, 页码: 105441
作者:  
Gao,Zhen;  Huang,Xiao-Yan;  Geng,Chang-An;  Li,Tian-Ze;  Chen,Ji-Jun
  |  收藏  |  浏览/下载:17/0  |  提交时间:2022/04/02
Traditional Chinese patent medicines for cancer treatment in China: a nationwide medical insurance data analysis 期刊论文  OAI收割
ONCOTARGET, 2015, 卷号: 6, 期号: 35, 页码: 38283-38295
作者:  
Wu, Min;  Lu, Peng;  Shi, Luwen;  Li, Shao
收藏  |  浏览/下载:37/0  |  提交时间:2016/03/19
Traditional Chinese herbs as chemical resource library for drug discovery of anti-infective and anti-inflammatory 期刊论文  OAI收割
JOURNAL OF ETHNOPHARMACOLOGY, 2014, 卷号: 155, 期号: 1, 页码: 589-598
作者:  
Ding, Weixian;  Gu, Jiangyong;  Cao, Liang;  Li, Na;  Ding, Gang
  |  收藏  |  浏览/下载:19/0  |  提交时间:2019/04/09
Apoptosis induction and G2/M arrest of 2-methyl-1,3,6-trihydroxy-9,10-anthraquinone from Rubia yunnanensis in human cervical cancer HeLa cells 期刊论文  OAI收割
PHARMAZIE, 2013, 卷号: 68, 期号: 4, 页码: 293-299
作者:  
Zeng, Guang-Zhi;  Fan, Jun-Ting;  Xu, Jun-Ju;  Li, Yan;  Tan, Ning-Hua
收藏  |  浏览/下载:43/0  |  提交时间:2015/05/14
2-Methyl-1,3,6-trihydroxy-9,10-anthraquinone (MTA)  one of the major components isolated from the traditional  Chinese medicine Rubia yunnanensis  exhibited inhibitory activity on the proliferation of several  human cancer cell lines. The results from an annexin V-FITC (fluoresein-5-isothiocyanate) apoptosis assay  and DNA content analysis showed that MTA exerted cytotoxicity via apoptosis induction and G2/M cell cycle  arrest in human cervical carcinoma HeLa cells. Further  MTA was found to induce apoptosis of HeLa cells  through the mitochondria-mediated pathway. It caused the translocation of Bax to the mitochondria and  release of cytochrome c into the cytosol  which caused the cleavage of caspase and poly(ADP-ribose)  polymerase and finally triggered the apoptosis. Furthermore  the p53/p21/Cdc2-cyclin B1 signaling was  found related to the G2/M arrest caused by MTA. The over-expression of p21 and down-expression of  cyclin B1 caused by MTA inactivated the Cdc2-cyclin B1 complex of G2/M checkpoint and finally caused  the G2/M arrest in HeLa cells. This study demonstrated that MTA is a potential anti-cancer component of  R. yunnanensis  a folk anti-cancer herb used in Yunnan  China.  
Antibacterial and Anti-inflammatory Activity of Traditional Chinese Herb Pairs, Angelica sinensis and Sophora flavescens 期刊论文  OAI收割
INFLAMMATION, 2012, 卷号: 35, 期号: 3, 页码: 913-919
作者:  
Han, Chunchao;  Guo, Jianyou
收藏  |  浏览/下载:27/0  |  提交时间:2015/10/08
Ursolic acid and its derivative inhibit protein tyrosine phosphatase 1B, enhancing insulin receptor phosphorylation and stimulating glucose uptake 期刊论文  OAI收割
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, 2006, 卷号: 1760, 期号: 10, 页码: 1505-1512
作者:  
Zhang, Wei;  Hong, Di;  Zhou, Yueyang;  Zhang, Yinan;  Shen, Qiang
  |  收藏  |  浏览/下载:142/0  |  提交时间:2019/01/08