机构

• 长春应用化学研究所 [13]
• 上海药物研究所 [9]
• 化学研究所 [7]
• 福建物质结构研究所 [3]
• 武汉物理与数学研究所 [3]
• 高能物理研究所 [3]
• 更多

采集方式

• OAI收割 [49]
• iSwitch采集 [2]

内容类型

• 期刊论文 [51]

发表日期

• 2021 [1]
• 2020 [1]
• 2018 [5]
• 2016 [1]
• 2013 [5]
• 2012 [1]
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学科主题

• Biochemist... [1]
• Biochemist... [1]
• Biochemist... [1]
• Biochemist... [1]
• Chemistry [1]
• Chemistry,... [1]
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筛选

浏览/检索结果: 共51条，第1-10条 帮助 条数/页： 5101520253035404550556065707580859095100 排序方式： 请选择题名升序题名降序提交时间升序提交时间降序作者升序作者降序发表日期升序发表日期降序 trans Single-Stranded DNA Cleavage via CRISPR/Cas14a1 Activated by Target RNA without Destruction 期刊论文  OAI收割 ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2021, 页码: 8 作者:  Wei, Yangdao;  Yang, Zhiqing;  Zong, Chengli;  Wang, Buhua;  Ge, Xiaolin   |  收藏  |  浏览/下载：42/0  |  提交时间：2021/12/01 CRISPR-Cas14a1  DNA cleavage  pathogenic bacteria  RNA  RNA detection platform   A label-free protamine-assisted colorimetric sensor for highly sensitive detection of S1 nuclease activity 期刊论文  OAI收割 ANALYST, 2020, 卷号: 145, 期号: 7, 页码: 2774-2778 作者:  Wen, Jiahui;  Liu, Yongming;  Li, Jingwen;  Lin, Hao;  Zheng, Yiran   |  收藏  |  浏览/下载：47/0  |  提交时间：2020/07/08 SINGLE-STRANDED-DNA  TURN-ON DETECTION  COPPER NANOPARTICLES  ENZYMATIC CLEAVAGE  OXIDATIVE DAMAGE  ASSAY  FLUORESCENCE  INHIBITION  GOLD  UNIVERSAL   Graphene quantum dots in alveolar macrophage: uptake-exocytosis, accumulation in nuclei, nuclear responses and DNA cleavage 期刊论文  OAI收割 PARTICLE AND FIBRE TOXICOLOGY, 2018, 卷号: 15, 页码: 45 作者:  Xu, Lina;  Dai, Yanhui;  Wang, Zhenyu;  Zhao, Jian;  Li, Fei   |  收藏  |  浏览/下载：95/0  |  提交时间：2020/07/08 Aminated graphene quantum dots  Macrophages  Endocytosis  Nuclear accumulation  DNA cleavage  Molecular docking   A Biomimetic Surface for Infection-resistance through Assembly of Metal-phenolic Networks 期刊论文  OAI收割 CHINESE JOURNAL OF POLYMER SCIENCE, 2018, 卷号: 36, 期号: 5, 页码: 576-583 作者:  Jiang, Ru-Jian;  Yan, Shun-Jie;  Tian, Li-Mei;  Xu, Shi-Ai;  Xin, Zhi-Rong   |  收藏  |  浏览/下载：42/0  |  提交时间：2019/04/09 Antibacterial Surface  Metal-phenolic Coating  Dna-cleavage  Biomimetic Surface   Intrinsic Nucleotide Preference of Diversifying Base Editors Guides Antibody Ex Vivo Affinity Maturation 期刊论文  OAI收割 CELL REPORTS, 2018, 卷号: 25, 期号: 4, 页码: 884-+ 作者:  Liu, Liu Daisy;  Huang, Min;  Dai, Pengfei;  Liu, Tingting;  Fan, Shuangshuang   |  收藏  |  浏览/下载：87/0  |  提交时间：2019/04/28 Induced Cytidine Deaminase  Class Switch Recombination  Somatic Hypermutation  Neutralizing Antibodies  Genomic Instability  Eukaryotic Genomes  Structural Basis  Mammalian-cells  Super-enhancers  Dna Cleavage   CRISPR-Cas9-mediated base-editing screening in mice identifies DND1 amino acids that are critical for primordial germ cell development 期刊论文  OAI收割 NATURE CELL BIOLOGY, 2018, 卷号: 20, 期号: 11, 页码: 1315-+ 作者:  Li, Qing;  Yang, Suming;  Yan, Meng;  Ding, Yifu;  Yin, Qi   |  收藏  |  浏览/下载：125/0  |  提交时间：2019/04/28 Embryonic Stem-cells  Mouse Embryos  Ter Mutation  Dna Cleavage  Genomic Dna  Gene  Generation  Sites  Complex  Rnas   Peptide Nucleic Acid-Assisted Label-free Detection of Single-Nucleotide Polymorphisms Based on Light Scattering of Carbon Nanotubes 期刊论文  OAI收割 ACS OMEGA, 2018, 卷号: 3, 期号: 12, 页码: 17835-17841 作者:  Xu, Wanxing;  Xing, Shu;  Xu, Xiaojun;  Xu, Mengjia;  Fu, Pan   |  收藏  |  浏览/下载：27/0  |  提交时间：2019/12/18 I-MOTIF DNA  STRAND DISPLACEMENT  PNA  CLEAVAGE  BINDING  PROBES  FUTURE  SNPS  RNA  BIOSENSOR   Biochemical characterization of a thermostable HNH endonuclease from deep-sea thermophilic bacteriophage GVE2 期刊论文  OAI收割 APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, 2016, 卷号: 100, 期号: 18, 页码: 8003-8012 作者:  Zhang, LK;  Huang, YC;  Xu DD(徐丹丹);  Gong Y(龚勇);  Xu, DD   |  收藏  |  浏览/下载：36/0  |  提交时间：2017/07/24 Bacteriophage  Thermophile  HNH motif  Endonuclease  DNA cleavage  Divalent metal ion   Apoptosis induction and G2/M arrest of 2-methyl-1,3,6-trihydroxy-9,10-anthraquinone from Rubia yunnanensis in human cervical cancer HeLa cells 期刊论文  OAI收割 PHARMAZIE, 2013, 卷号: 68, 期号: 4, 页码: 293-299 作者:  Zeng, Guang-Zhi;  Fan, Jun-Ting;  Xu, Jun-Ju;  Li, Yan;  Tan, Ning-Hua 收藏  |  浏览/下载：40/0  |  提交时间：2015/05/14 2-Methyl-1,3,6-trihydroxy-9,10-anthraquinone (MTA)  one of the major components isolated from the traditional  Chinese medicine Rubia yunnanensis  exhibited inhibitory activity on the proliferation of several  human cancer cell lines. The results from an annexin V-FITC (fluoresein-5-isothiocyanate) apoptosis assay  and DNA content analysis showed that MTA exerted cytotoxicity via apoptosis induction and G2/M cell cycle  arrest in human cervical carcinoma HeLa cells. Further  MTA was found to induce apoptosis of HeLa cells  through the mitochondria-mediated pathway. It caused the translocation of Bax to the mitochondria and  release of cytochrome c into the cytosol  which caused the cleavage of caspase and poly(ADP-ribose)  polymerase and finally triggered the apoptosis. Furthermore  the p53/p21/Cdc2-cyclin B1 signaling was  found related to the G2/M arrest caused by MTA. The over-expression of p21 and down-expression of  cyclin B1 caused by MTA inactivated the Cdc2-cyclin B1 complex of G2/M checkpoint and finally caused  the G2/M arrest in HeLa cells. This study demonstrated that MTA is a potential anti-cancer component of  R. yunnanensis  a folk anti-cancer herb used in Yunnan  China.   Synthesis, characterization, and DNA binding of a novel ligand and its Cu(II) complex 期刊论文  OAI收割 JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY, 2013, 卷号: 18, 期号: 8, 页码: 993-1003 作者:  Li, MJ;  Lan, TY;  Lin, ZS;  Yi, CQ;  Chen, GN 收藏  |  浏览/下载：29/0  |  提交时间：2016/04/08 Copper(II) complex  DNA binding  Cytotoxicity  Nucleolytic cleavage