中国科学院机构知识库网格系统: 检索

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	Discovery of novel 2,4-diarylaminopyrimidine derivatives as potent and selective epidermal growth factor receptor (EGFR) inhibitors against L858R/T790M resistance mutation 期刊论文 OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 152, 页码: 298-306 作者: Yan, Qi; Chen, Yuzhe; Tang, Baiyou; Xiao, Qiang; Qu, Rong \| 收藏 \| 浏览/下载：86/0 \| 提交时间：2019/01/08 EGFR inhibitors Pyrimidine derivatives Mutant selective inhibitors AZD9291 T790M
	A structure-guided optimization of pyrido[2,3-d]pyrimidin-7-ones as selective inhibitors of EGFR(L858R/T790M) mutant with improved pharmacokinetic properties 期刊论文 OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2017, 卷号: 126, 页码: 1107-1117 作者: Yu, Lei; Huang, Minhao; Xu, Tianfeng; Tong, Linjiang; Yan, Xiao-e \| 收藏 \| 浏览/下载：41/0 \| 提交时间：2019/01/08 EGFR(T790M) mutant Pyrido[2,3-d]pyrimidin-7-ones Pharmacokinetic property NSCLC Irreversible inhibitor
	Identification of hydrazone moiety-bearing aminopyrimidines as potent antitumor agents with selective inhibition of gefitinib-resistant H1975 cancer cells 期刊论文 OAI收割 CHINESE CHEMICAL LETTERS, 2017, 卷号: 28, 期号: 5, 页码: 991-994 作者: Qin MingZe; Wang Lei; Yan Shuang; Ma JunJie; Tian Ye \| 收藏 \| 浏览/下载：49/0 \| 提交时间：2021/02/02 TYROSINE KINASE INHIBITOR LUNG-CANCER RECEPTOR T790M MUTANT MUTATION Aminopyrimidines EGFR T790M/L858R Selectivity Anti-resistance Antiproliferative activity
	Identification of hydrazone moiety-bearing aminopyrimidines as potent antitumor agents with selective inhibition of gefitinib-resistant H1975 cancer cells 期刊论文 OAI收割 CHINESE CHEMICAL LETTERS, 2017, 卷号: 28, 期号: 5, 页码: 991-994 作者: Qin MingZe; Wang Lei \| 收藏 \| 浏览/下载：52/0 \| 提交时间：2021/02/02 TYROSINE KINASE INHIBITOR LUNG-CANCER RECEPTOR T790M MUTANT MUTATION Aminopyrimidines EGFR T790M/L858R Selectivity Anti-resistance Antiproliferative activity