中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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CAS IR Grid
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上海药物研究所 [55]
合肥物质科学研究院 [16]
广州生物医药与健康... [15]
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期刊论文 [86]
学位论文 [5]
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JC-010a, a novel selective SHP2 allosteric inhibitor, overcomes RTK/non-RTK-mediated drug resistance in multiple oncogene-addicted cancers
期刊论文
OAI收割
CANCER LETTERS, 2024, 卷号: 582, 页码: 15
作者:
Lu, Xuxiu
;
Yu, Rilei
;
Li, Zhen
;
Yang, Mengke
;
Dai, Jiajia
  |  
收藏
  |  
浏览/下载:13/0
  |  
提交时间:2024/04/07
Acquired resistance
Cancer
NSCLC
JC-010a
SHP2
Epigenetic-based combination therapy and liposomal codelivery overcomes osimertinib-resistant NSCLC via repolarizing tumor-associated macrophages
期刊论文
OAI收割
ACTA PHARMACOLOGICA SINICA, 2023, 页码: 12
作者:
Lin, Ting-ting
;
Xiong, Wei
;
Chen, Gui-hua
;
He, Yang
;
Long, Li
  |  
收藏
  |  
浏览/下载:6/0
  |  
提交时间:2024/01/26
osimertinib resistance
targeted drug delivery
liposomes
panobinostat
tumor-associated macrophage
combination therapy
Synthesis, and biological evaluation of EGFR/HER2-NAMPT conjugates for tumor treatment
期刊论文
OAI收割
MOLECULAR DIVERSITY, 2023, 页码: 20
作者:
Ding, Mengyuan
;
Shen, Qianqian
;
Lu, Wei
  |  
收藏
  |  
浏览/下载:62/0
  |  
提交时间:2023/10/17
EGFR
HER2
NAMPT
Resistance
Selectivity
Molecular docking
Discovery of HCD3514 as a potent EGFR inhibitor against C797S mutation in vitro and in vivo
期刊论文
OAI收割
JOURNAL OF CANCER, 2023, 卷号: 14, 期号: 1, 页码: 152-162
作者:
Lai, Mengzhen
;
Zhang, Tao
;
Chen, Hao
;
Song, Peiran
;
Tong, Linjiang
  |  
收藏
  |  
浏览/下载:80/0
  |  
提交时间:2023/04/10
fourth-generation EGFR inhibitor
EGFRC797S mutation
NSCLC
drug resistance
small molecular inhibitor
Design, synthesis and evaluation of the Brigatinib analogues as potent inhibitors against tertiary EGFR mutants (EGFR(del19/T790M/C797S) and EGFR(L858R/T790M/C797S))
期刊论文
OAI收割
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2022, 卷号: 72, 页码: 11
作者:
Fang, Haotian
;
Wu, Yingming
;
Xiao, Qitao
;
He, Dongbo
;
Zhou, Tongrui
  |  
收藏
  |  
浏览/下载:73/0
  |  
提交时间:2022/08/16
Non-small cell lung cancer
EGFR
Triple mutations
C797S
EGFR-TKIs
A Phase 2 Study of Befotertinib in Patients with EGFR T790M Mutated NSCLC after Prior EGFR TKIs
期刊论文
OAI收割
JOURNAL OF THORACIC ONCOLOGY, 2022, 卷号: 17
作者:
Lu, S.
;
Zhang, Y.
;
Zhang, G.
;
Zhou, J.
;
Cang, S.
  |  
收藏
  |  
浏览/下载:73/0
  |  
提交时间:2022/12/23
third-generation EGFR-TKI
befotertinib
T790M
Impact of clinical and molecular features on efficacy and outcome of patients with non-small cell lung cancer receiving second-line osimertinib
期刊论文
OAI收割
BMC CANCER, 2022, 卷号: 22
作者:
Jin, Ying
;
Lin, Chen
;
Shi, Xun
;
He, Qiong
;
Yan, Junrong
  |  
收藏
  |  
浏览/下载:71/0
  |  
提交时间:2022/12/23
Clinical and molecular features
Efficacy and outcome
EGFR T790M mutation
Non-small-cell lung cancer
Osimertinib
Conformational Constrained 4-(1-Sulfonyl-3-indol)yl-2-phenylaminopyrimidine Derivatives as New Fourth-GenerationEpidermal Growth Factor Receptor Inhibitors Targeting T790M/C797S Mutations br
期刊论文
OAI收割
JOURNAL OF MEDICINAL CHEMISTRY, 2022, 卷号: 65, 期号: 9, 页码: 6840-6858
作者:
Chen, Hao
;
Lai, Mengzhen
;
Zhang, Tao
;
Chen, Yuqing
;
Tong, Linjiang
  |  
收藏
  |  
浏览/下载:23/0
  |  
提交时间:2022/08/16
Conformational Constrained 4-(1-Sulfonyl-3-indol)yl-2-phenylaminopyrimidine Derivatives as New Fourth-GenerationEpidermal Growth Factor Receptor Inhibitors Targeting T790M/C797S Mutations
期刊论文
OAI收割
JOURNAL OF MEDICINAL CHEMISTRY, 2022, 卷号: 65, 期号: 9, 页码: 6840-6858
作者:
Chen, Hao
;
Lai, Mengzhen
;
Zhang, Tao
;
Chen, Yuqing
;
Tong, Linjiang
  |  
收藏
  |  
浏览/下载:5/0
  |  
提交时间:2024/03/21
Discovery of N-(3-bromo-1H-indol-5-yl)-quinazolin-4-amine as an effective molecular skeleton to develop reversible/irreversible pan-HER inhibitors
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2022, 卷号: 233, 页码: 13
作者:
Tang, Qidong
;
Peng, Ting
;
Hu, Jie
;
Zhang, Tao
;
Chen, Pengqin
  |  
收藏
  |  
浏览/下载:30/0
  |  
提交时间:2022/08/16
Reversible
irreversible pan-HER inhibitor
Quinazolin-4-amine derivatives
Anti-tumor
Structure-activity relationship