机构

• 上海药物研究所 [19]
• 合肥物质科学研究院 [4]
• 上海生物化学与细胞生... [3]
• 化学研究所 [2]

采集方式

• OAI收割 [28]

内容类型

• 期刊论文 [28]

发表日期

• 2025 [2]
• 2024 [5]
• 2023 [4]
• 2022 [4]
• 2021 [2]
• 2020 [1]
• 更多

学科主题

• Cell Biolo... [1]
• Oncology [1]
• Oncology; ... [1]
• Respirator... [1]

筛选

浏览/检索结果: 共28条，第1-10条 帮助 条数/页： 5101520253035404550556065707580859095100 排序方式： 请选择提交时间升序提交时间降序作者升序作者降序题名升序题名降序发表日期升序发表日期降序 An overview of PROTACs targeting KRAS and SOS1 as antitumor agents 期刊论文  OAI收割 BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2025, 卷号: 125, 页码: 13 作者:  Han, Zhiqiu;  Wu, Qianping;  Rao, Hongxin;  Xu, Tianfeng;  Zhou, Chuan   |  收藏  |  浏览/下载：5/0  |  提交时间：2025/08/20 KRAS  SOS1  PROTAC  Antitumor agent   Design and structural optimization of novel SOS1 inhibitors in KRAS-driven cancers 期刊论文  OAI收割 BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2025, 卷号: 125, 页码: 8 作者:  Chen, Yating;  Liu, Qiupei;  Meng, Xianghui;  Cao, Wenxu;  Duo, Lihui   |  收藏  |  浏览/下载：7/0  |  提交时间：2025/08/20 SOS1 inhibitor  KRAS mutation  SOS1-KRAS interaction  Resistance   Identification of USP2 as a novel target to induce degradation of KRAS in myeloma cells 期刊论文  OAI收割 ACTA PHARMACEUTICA SINICA B, 2024, 卷号: 14, 期号: 12, 页码: 5235-5248 作者:  Wang, Yingying;  Zhang, Youping;  Luo, Hao;  Wei, Wei;  Liu, Wanting   |  收藏  |  浏览/下载：31/0  |  提交时间：2025/04/01 Ubiquitin-specific protease 2  KRAS  Gambogic acid  Multiple myeloma  Degradation  Ubiquitination  Allosteric pocket  Deubiquitination   An updated patent review of SOS1 inhibitors (2022-present) 期刊论文  OAI收割 EXPERT OPINION ON THERAPEUTIC PATENTS, 2024, 页码: 15 作者:  Zhou, Guizhen;  Zhou, Chuan;  Ma, Xinyi;  Xu, Jiahang;  Zhou, Zehui   |  收藏  |  浏览/下载：21/0  |  提交时间：2024/12/11 SOS1  KRAS  cancer  inhibitor  drug discovery   Unraveling the CDK9/PP2A/ERK Network in Transcriptional Pause Release and Complement Activation in KRAS-mutant Cancers 期刊论文  OAI收割 ADVANCED SCIENCE, 2024, 页码: 20 作者:  Wang, Yafang;  Xu, Lansong;  Ling, Lijun;  Yao, Mingyue;  Shi, Shangxuan   |  收藏  |  浏览/下载：36/0  |  提交时间：2024/10/21 KRAS  CDK9  ERK  complement activation  immunosuppression   Design, synthesis, and bioevaluation of SOS1 PROTACs derived from pyrido [2,3- d ]pyrimidin-7-one-based SOS1 inhibitor 期刊论文  OAI收割 BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2024, 卷号: 107, 页码: 9 作者:  Wang, Kun;  Zhou, Zehui;  Ma, Xinyi;  Xu, Jiahang;  Xu, Wangyang   |  收藏  |  浏览/下载：38/0  |  提交时间：2024/07/12 SOS1  KRAS mutation  PROTAC  Anti-cancer activity   Transcription factor EHF interacting with coactivator AJUBA aggravates malignancy and acts as a therapeutic target for gastroesophageal adenocarcinoma 期刊论文  OAI收割 ACTA PHARMACEUTICA SINICA B, 2024, 卷号: 14 作者:  Peng, Li;  Jiang, Yanyi;  Chen, Hengxing;  Wang, Yongqiang;  Lan, Qiusheng   |  收藏  |  浏览/下载：23/0  |  提交时间：2024/11/22 EHF  AJUBA  KRAS pathway  Enhancer  Core transcriptional regulatory circuitry  Gastroesophageal adenocarcinoma  Gastric adenocarcinoma  Esophageal adenocarcinoma  Transcription factor  Coactivator  Lipid nanoparticles   Targeting ST8SIA6-AS1 counteracts KRASG12C inhibitor resistance through abolishing the reciprocal activation of PLK1/c-Myc signaling 期刊论文  OAI收割 EXPERIMENTAL HEMATOLOGY & ONCOLOGY, 2023, 卷号: 12, 期号: 1, 页码: 22 作者:  Wang, Yafang;  Yao, Mingyue;  Li, Cheng;  Yang, Kexin;  Qin, Xiaolong   |  收藏  |  浏览/下载：45/0  |  提交时间：2024/01/26 KRAS(G12C)  c-Myc  PLK1  LncRNA  ST8SIA6-AS1  Drug resistance   From bench to bedside: current development and emerging trend of KRAS-targeted therapy 期刊论文  OAI收割 ACTA PHARMACOLOGICA SINICA, 2023, 页码: 18 作者:  Chen, Yi;  Liu, Qiu-pei;  Xie, Hua;  Ding, Jian   |  收藏  |  浏览/下载：77/0  |  提交时间：2024/01/16 KRAS mutation  KRAS(G12C) inhibitor  Pan-KRAS inhibitor  SHP2 allosteric inhibitor  SOS1 inhibitor  combination therapy   Tetrandrine synergizes with MAPK inhibitors in treating KRAS-mutant pancreatic ductal adenocarcinoma via collaboratively modulating the TRAIL-death receptor axis 期刊论文  OAI收割 PHARMACOLOGICAL RESEARCH, 2023, 卷号: 197, 页码: 12 作者:  Tang, Shuai;  Duan, Yichen;  Yuan, Tao;  Hu, Yutinh;  Yuan, Liang   |  收藏  |  浏览/下载：37/0  |  提交时间：2023/12/11 KRAS  Pancreatic ductal adenocarcinoma  MAPK pathway  Tetrandrine  TRAIL  Death receptors