机构

• 上海药物研究所 [40]
• 过程工程研究所 [11]
• 昆明植物研究所 [9]
• 新疆理化技术研究所 [3]
• 大连化学物理研究所 [3]
• 金属研究所 [2]
• 更多

采集方式

• OAI收割 [72]
• iSwitch采集 [2]

内容类型

• 期刊论文 [74]

发表日期

• 2022 [2]
• 2020 [2]
• 2019 [5]
• 2018 [7]
• 2017 [2]
• 2016 [3]
• 更多

学科主题

• Chemistry [4]
• Pharmacolo... [4]
• Biochemist... [2]
• Biochemist... [1]
• Chemistry,... [1]
• Chemistry,... [1]
• 更多

筛选

浏览/检索结果: 共74条，第1-10条 帮助 条数/页： 5101520253035404550556065707580859095100 排序方式： 请选择题名升序题名降序提交时间升序提交时间降序作者升序作者降序发表日期升序发表日期降序 Computer-Aided Design of Self-Assembled Nanoparticles to Enhance Cancer Chemoimmunotherapy via Dual-Modulation Strategy 期刊论文  OAI收割 ADVANCED HEALTHCARE MATERIALS, 2025, 页码: 15 作者:  Shan, Xiaoting;  Cai, Ying;  Zhu, Binyu;  Sun, Xujie;  Zhou, Lingli   |  收藏  |  浏览/下载：6/0  |  提交时间：2025/04/01 cancer chemoimmunotherapy  computer-aided design  nanoparticles  pharmacophore hybridization  triple-negative breast cancer   Discovery of orally effective and safe GPR40 agonists by incorporating a chiral, rigid and polar sulfoxide into 8-position to the carboxylic acid 期刊论文  OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2023, 卷号: 251, 页码: 115267 作者:  Chen, Cheng;  Guo, Shi-Meng;  Sun, Yuanjun;  Li, He;  Hu, Nan   |  收藏  |  浏览/下载：11/0  |  提交时间：2024/03/27 GPR40  Glucose-stimulated insulin secretion  Type 2 diabetes mellitus  Lipophilicity  Liver safety  Three-in-one pharmacophore  2-(phenylsulfinyl)acetic acid   Design, synthesis and biological evaluation of novel dihydrobenzodioxine derivatives as HBV capsid protein inhibitors 期刊论文  OAI收割 BIOORGANIC CHEMISTRY, 2022, 卷号: 128, 页码: 12 作者:  Liu, Linyue;  Li, Chuanju;  Xie, Yong;  Zhang, Lei;  Chen, Yunfu   |  收藏  |  浏览/下载：18/0  |  提交时间：2023/10/17 HBV  Capsid protein inhibitors  Pharmacophore hybrid  Scaffold hopping  HepAD38 cells   Review of Voltage-gated Calcium Channel alpha 2 delta Subunit Ligands for the Treatment of Chronic Neuropathic Pain and Insight into Structure-activity Relationship (SAR) by Pharmacophore Modeling 期刊论文  OAI收割 CURRENT MEDICINAL CHEMISTRY, 2022, 卷号: 29, 期号: 30, 页码: 5097-5112 作者:  Chen, Yuting;  Wu, Qingqing;  Jin, Zhengsheng;  Qin, Yanlan;  Meng, Fancui   |  收藏  |  浏览/下载：30/0  |  提交时间：2022/11/11 Voltage-gated calcium channel  alpha 2 delta subunit  neuropathic pain  structure-activity relationship (SAR)  pharmacophore modeling  gabapentinoids   Discovery of potentially biased agonists of mu-opioid receptor (MOR) through molecular docking, pharmacophore modeling, and MD simulation 期刊论文  OAI收割 COMPUTATIONAL BIOLOGY AND CHEMISTRY, 2021, 卷号: 90, 页码: 107405 作者:  Jiang,Xuan;  Li,Shuxiang;  Zhang,Hongbin;  Wang,Liang-Liang   |  收藏  |  浏览/下载：17/0  |  提交时间：2022/04/02 mu-Opioid receptors (MOR)  Biased ligands  Molecular docking  Hip-hop pharmacophore  MD simulation   Pharmacophore-Based Virtual Screening Toward the Discovery of Novel Anti-echinococcal Compounds 期刊论文  OAI收割 FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY, 2020, 卷号: 10, 页码: 12 作者:  Liu, Congshan;  Yin, Jianhai;  Yao, Jiaqing;  Xu, Zhijian;  Tao, Yi   |  收藏  |  浏览/下载：44/0  |  提交时间：2020/07/01 echinococcosis  Echinococcus multilocularis  pharmacophore modeling  virtual screenings  in vitro drug screen  cytotoxicity  E  multilocularis-infected mice  pharmacokinetics analysis   Efficient synthesis, biological evaluation, and docking study of isatin based derivatives as caspase inhibitors 期刊论文  OAI收割 JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, 2020, 卷号: 35, 期号: 1, 页码: 1674-1684 作者:  Firoozpour, Loghman;  Gao, Lixin;  Moghimi, Setareh;  Pasalar, Parvin;  Davoodi, Jamshid   |  收藏  |  浏览/下载：22/0  |  提交时间：2020/12/24 Caspase inhibitor  Isatin sulphonamides  docking studies  Pharmacophore  apoptosis   Discovery of new multifunctional selective acetylcholinesterase inhibitors: structure-based virtual screening and biological evaluation 期刊论文  OAI收割 JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN, 2019, 卷号: 33, 期号: 5, 页码: 521-530 作者:  Jiang, Cheng-Shi   |  收藏  |  浏览/下载：37/0  |  提交时间：2020/07/01 AChE inhibitor  Pharmacophore model  Molecular docking  Anti-A aggregation  Neuroprotective activity   Three new compounds with nitric oxide inhibitory activity from Tirpitzia sinensis, an ethnomedicinal plant from Southwest China 期刊论文  OAI收割 BMC CHEMISTRY, 2019, 卷号: 13, 页码: 12 作者:  Gu, Ronghui;  Wang, Yuehu;  Wu, Shibiao;  Wang, Yeling;  Li, Ping   |  收藏  |  浏览/下载：77/0  |  提交时间：2019/07/29 Tirpitzia sinensis  Linaceae  Lignans  Inflammatory  NO inhibition  Pharmacological targets  Pharmacophore  In silico   Identification of potential AMPK activator by pharmacophore modeling, molecular docking and QSAR study 期刊论文  OAI收割 COMPUTATIONAL BIOLOGY AND CHEMISTRY, 2019, 卷号: 79, 页码: 165-176 作者:  Li, Yingying;  Peng, Jiale;  Li, Penghua;  Du, Haibo;  Li, Yaping   |  收藏  |  浏览/下载：68/0  |  提交时间：2019/07/29 Pharmacophore modeling  Molecular docking  Quantitative structure activity relationship (QSAR)  Molecular dynamics  AMPK  Activator