中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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CAS IR Grid
机构
上海药物研究所 [10]
生态环境研究中心 [1]
采集方式
OAI收割 [11]
内容类型
期刊论文 [11]
发表日期
2025 [1]
2023 [2]
2022 [1]
2019 [2]
2017 [1]
2016 [1]
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Development of novel epoxyketone macrocyclic peptidyl proteasome inhibitors through OPA-mediated one-step cyclization of unprotected peptides
期刊论文
OAI收割
BIOORGANIC CHEMISTRY, 2025, 卷号: 156, 页码: 16
作者:
Zeng, Gongruixue
;
Xu, Gaoya
;
Gao, Lixin
;
Zheng, Xiaoli
;
Chi, Xinglong
  |  
收藏
  |  
浏览/下载:9/0
  |  
提交时间:2025/04/01
Proteasome inhibitors
Macrocycle
Stability
Anti-cancer activities
Proteasome inhibitors reduce CD73 expression partly
via
decreasing p-ERK in NSCLC cells
期刊论文
OAI收割
LIFE SCIENCES, 2023, 卷号: 332, 页码: 10
作者:
Su, Ai-Ling
;
Tian, Chang-Qing
;
Ou, Ying-Jie
;
Bao, Xu-Bin
;
Huan, Xia-Juan
  |  
收藏
  |  
浏览/下载:22/0
  |  
提交时间:2023/12/08
CD73
Proteasome inhibitors
ERK
NSCLC
Exploration of novel four-membered-heterocycle constructed peptidyl proteasome inhibitors with improved metabolic stability for cancer treatment
期刊论文
OAI收割
BIOORGANIC CHEMISTRY, 2023, 卷号: 138, 页码: 22
作者:
Wang, Hanlin
;
Wu, Zhaoxiao
;
Cao, Yu
;
Gao, Lixin
;
Shao, Jiaan
  |  
收藏
  |  
浏览/下载:25/0
  |  
提交时间:2023/10/17
Metabolic stability
Four-membered heterocycles
Proteasome inhibitors
Multiple myeloma
Metabolism guided optimization of peptidomimetics as non-covalent proteasome inhibitors for cancer treatment
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2022, 卷号: 233, 页码: 18
作者:
Cao, Yu
;
Tu, Yutong
;
Fu, Liping
;
Yu, Qian
;
Gao, Lixin
  |  
收藏
  |  
浏览/下载:43/0
  |  
提交时间:2022/06/15
Metabolism
Design
Proteasome inhibitors
Non-covalent
Multiple myeloma
Covalent docking modelling-based discovery of tripeptidyl epoxyketone proteasome inhibitors composed of aliphatic-heterocycles
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 164, 页码: 602-614
作者:
Dong, Xiao-Wu
;
Zhang, Jian-Kang
;
Xu, Lei
;
Che, Jin-Xin
;
Cheng, Gang
  |  
收藏
  |  
浏览/下载:27/0
  |  
提交时间:2020/07/01
Proteasome inhibitors
Tripeptide
Covalent docking
Interaction mode
Exploration of novel macrocyclic dipeptide N-benzyl amides as proteasome inhibitors
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 164, 页码: 423-439
作者:
Yu, Jianjun
;
Liu, Jieyu
;
Li, Daqiang
;
Xu, Lei
;
Hong, Duidui
  |  
收藏
  |  
浏览/下载:32/0
  |  
提交时间:2020/07/01
Proteasome inhibitors
Macrocyclic dipeptides
N-Benzyl amides
Metabolic stability
Exploration of novel piperazine or piperidine constructed non-covalent peptidyl derivatives as proteasome inhibitors
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2017, 卷号: 126, 页码: 1056-1070
作者:
Zhuang, Rangxiao
;
Gao, Lixin
;
Lv, Xiaoqing
;
Xi, Jianjun
;
Sheng, Li
  |  
收藏
  |  
浏览/下载:30/0
  |  
提交时间:2019/01/08
Proteasome inhibitors
Piperazine or piperidine
Non-covalent
Peptidyl derivatives
Anti-cancer
Design, synthesis and biological evaluation of novel non-covalent piperidine-containing peptidyl proteasome inhibitors
期刊论文
OAI收割
BIOORGANIC & MEDICINAL CHEMISTRY, 2016, 卷号: 24, 期号: 23, 页码: 6206-6214
作者:
Zhang, Jiankang
;
Gao, Lixin
;
Xi, Jianjun
;
Sheng, Li
;
Zhao, Yanmei
  |  
收藏
  |  
浏览/下载:61/0
  |  
提交时间:2019/01/08
Proteasome inhibitors
Piperidine
Non-covalent
Anti-cancer
SARs
Design, Synthesis and Biological Evaluation of Peptidyl Epoxyketone Proteasome Inhibitors Composed of beta-amino Acids
期刊论文
OAI收割
CHEMICAL BIOLOGY & DRUG DESIGN, 2014, 卷号: 84, 期号: 5, 页码: 497-504
作者:
Zhang, Jiankang
;
Han, Mengmeng
;
Ma, Xiaodong
;
Xu, Lei
;
Cao, Jiayi
  |  
收藏
  |  
浏览/下载:16/0
  |  
提交时间:2019/01/08
anti-cancer
di- and tripeptides
epoxyketone
proteasome inhibitors
-amino acid
Design, synthesis and biological evaluation of novel tripeptidyl epoxyketone derivatives constructed from beta-amino acid as proteasome inhibitors
期刊论文
OAI收割
BIOORGANIC & MEDICINAL CHEMISTRY, 2014, 卷号: 22, 期号: 11, 页码: 2955-2965
作者:
Zhang, Jiankang
;
Cao, Jiayi
;
Xu, Lei
;
Zhou, Yubo
;
Liu, Tao
  |  
收藏
  |  
浏览/下载:16/0
  |  
提交时间:2019/01/08
Proteasome inhibitors
beta-Amino acid
Epoxyketone
Anti-cancer
Drug design
SARs