中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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CAS IR Grid
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上海药物研究所 [80]
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Structure-based design of potent FABP4 inhibitors with high selectivity against FABP3
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2024, 卷号: 264, 页码: 10
作者:
Chen, Guofeng
;
Xie, Hang
;
Liu, Jiayuan
;
Shao, Qiang
;
Li, Minjun
  |  
收藏
  |  
浏览/下载:7/0
  |  
提交时间:2024/01/26
Methyl substitution
Selectivity
FABP4 inhibitor
Anti-inflammation
Metabolic stability
Benzothiozinone derivatives with anti-tubercular Activity-Further side chain investigation
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2024, 卷号: 264, 页码: 11
作者:
Wu, Xiaomei
;
Wang, Wenxin
;
Stelitano, Giovanni
;
Riabova, Olga
;
Wang, Bin
  |  
收藏
  |  
浏览/下载:8/0
  |  
提交时间:2024/01/26
Anti -tubercular activity
DprE1 inhibitor
Benzothiazinone derivatives
Structure activity relationship
Discovery and optimization of thieno[3,2-d]pyrimidine derivatives as highly selective inhibitors of cyclin-dependent kinase 7
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2024, 卷号: 263, 页码: 21
作者:
Zhang, Hongjin
;
Lin, Guohao
;
Jia, Suyun
;
Zhang, Ying
;
Wu, Jianbo
  |  
收藏
  |  
浏览/下载:5/0
  |  
提交时间:2024/01/26
Thieno[3
d ]pyrimidine derivative
Cyclin-dependent kinase 7
Small molecule inhibitor
Kinome selectivity
Triple negative breast cancer
Elevational characteristics of soil bacterial community and their responses to soil translocation at a mountainside in northwest Sichuan, China
期刊论文
OAI收割
SCIENTIFIC REPORTS, 2023, 卷号: 13, 期号: 1, 页码: 13
作者:
Wang, Xuemei
;
Huang, Tianzhi
;
Li, Yunyun
;
Zhao, Guang
;
Zhao, Jixia
  |  
收藏
  |  
浏览/下载:7/0
  |  
提交时间:2023/12/07
Design, synthesis and biological evaluation of chalcone derivatives as potent and orally active hCYP3A4 inhibitors
期刊论文
OAI收割
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2023, 卷号: 95, 页码: 9
作者:
Lu, Shiwei
;
Zhang, Feng
;
Gong, Jiahao
;
Huang, Jian
;
Zhu, Guanghao
  |  
收藏
  |  
浏览/下载:10/0
  |  
提交时间:2023/12/08
Cytochrome P450 3A4 (CYP3A4)
Inhibitors
Isoquinoline chalcones
Orally active
Effects of exposure to nanoplastics on the gill of mussels
Mytilus
galloprovincialis:
An integrated perspective from multiple biomarkers
期刊论文
OAI收割
MARINE ENVIRONMENTAL RESEARCH, 2023, 卷号: 191, 页码: 8
作者:
Wang, Xin
;
Shao, Shengyuan
;
Zhang, Tianyu
;
Zhang, Qianqian
;
Yang, Dinglong
  |  
收藏
  |  
浏览/下载:8/0
  |  
提交时间:2023/11/15
Nanoplastics
Nanotoxicology
Biomarkers
Invertebrates
Ecotoxicology
Exploration of novel four-membered-heterocycle constructed peptidyl proteasome inhibitors with improved metabolic stability for cancer treatment
期刊论文
OAI收割
BIOORGANIC CHEMISTRY, 2023, 卷号: 138, 页码: 22
作者:
Wang, Hanlin
;
Wu, Zhaoxiao
;
Cao, Yu
;
Gao, Lixin
;
Shao, Jiaan
  |  
收藏
  |  
浏览/下载:13/0
  |  
提交时间:2023/10/17
Metabolic stability
Four-membered heterocycles
Proteasome inhibitors
Multiple myeloma
Discovery of novel triazine derivatives as potent retinoic acid receptor-related orphan receptor gamma t (ROR gamma t) inverse agonists
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2023, 卷号: 256, 页码: 18
作者:
Lu, Lixue
;
Chen, Song
;
Yu, Mingcheng
;
Zhou, Ronghui
;
Guo, Siqi
  |  
收藏
  |  
浏览/下载:15/0
  |  
提交时间:2023/10/17
ROR gamma t
Triazines
Inverse agonist
Psoriasis
Autoimmune diseases
Soil CO2 emission reduction with no-tillage and medium nitrogen fertilizer applications in semi-humid maize cropland in North China Plain
期刊论文
OAI收割
EUROPEAN JOURNAL OF AGRONOMY, 2023, 卷号: 147, 页码: 126838
作者:
Li, Zhaoxin
;
Zhang, Qiuying
;
Li, Fadong
;
Li, Zhao
;
Qiao, Yunfeng
  |  
收藏
  |  
浏览/下载:13/0
  |  
提交时间:2023/06/10
No-tollage
Nitrogen fertilizer
SoilCO2 emissions
Maize yields
Microbial mechanism
Discovery of seven-membered ring berberine analogues as highly potent and specific hCES2A inhibitors
期刊论文
OAI收割
CHEMICO-BIOLOGICAL INTERACTIONS, 2023, 卷号: 378, 页码: 11
作者:
Yang, Yun
;
Xiong, Yuan
;
Zhu, Guanghao
;
Sun, Mengru
;
Zou, Kun
  |  
收藏
  |  
浏览/下载:22/0
  |  
提交时间:2023/10/17
Human carboxylesterase 2 (hCES2A)
Berberine analogues
Structure -activity relationships (SAR)
Inhibition kinetics
Selectivity