机构

• 上海药物研究所 [18]
• 成都生物研究所 [3]
• 海洋研究所 [2]

采集方式

• OAI收割 [23]

内容类型

• 期刊论文 [23]

发表日期

• 2025 [2]
• 2024 [3]
• 2023 [1]
• 2021 [4]
• 2020 [3]
• 2017 [2]
• 更多

学科主题

• Cell Biolo... [2]
• Oncology [1]
• 天然产物研究 [1]

筛选

浏览/检索结果: 共23条，第1-10条 帮助 条数/页： 5101520253035404550556065707580859095100 排序方式： 请选择题名升序题名降序发表日期升序发表日期降序提交时间升序提交时间降序作者升序作者降序 Synthesis and Evaluation of Optical Properties, SHP2 Inhibitory Activity, and Cellular Imaging for Novel 2-Quinolone Derivatives 期刊论文  OAI收割 ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY, 2025, 页码: 10 作者:  Zhang, Chun   |  收藏  |  浏览/下载：6/0  |  提交时间：2025/05/27 Fluorescent inhibitors  SHP2  2-quinolone derivatives  optical properties  drug tracing  medical diagnosis   Synthesis, fluorescence properties of novel thiazolo[3,2-b][1,2,4]triazol derivatives as potent SHP2 inhibitors and its uses in sensing for Fe3+and cell imaging 期刊论文  OAI收割 JOURNAL OF MOLECULAR STRUCTURE, 2025, 卷号: 1324, 页码: 12 作者:  Yan, Xue;  Zhang, Chun;  Gao, Li-Xin;  Cao, Zi-Tong;  Gan, Su-Ya   |  收藏  |  浏览/下载：22/0  |  提交时间：2025/01/14 Thiazolo[3,2-b][1,2,4]triazole  Salicylic acid  Fe3+ion  Fluorescence property  SHP2   SHP2-Triggered Endothelial Cell Activation Fuels Estradiol-Independent Endometrial Sterile Inflammation 期刊论文  OAI收割 ADVANCED SCIENCE, 2024, 页码: 22 作者:  Pan, Jie;  Qu, Jiao;  Fang, Wen;  Zhao, Lixin;  Zheng, Wei   |  收藏  |  浏览/下载：20/0  |  提交时间：2024/10/21 cell-cell interaction  endometrial hyperplasia  endothelial cell activation  SHP2-RIPK1-AP-1 axis  sterile inflammation   Small Molecule SHP2 Inhibitor LXQ-217 affects Lung Cancer Cell Proliferation in Vitro and in Vivo 期刊论文  OAI收割 CHEMISTRY & BIODIVERSITY, 2024, 页码: 11 作者:  Sun, Hao;  Bai, Xiaoyi;  Zhang, Yiting;  Gao, Yanan;  Dai, Jiajia   |  收藏  |  浏览/下载：17/0  |  提交时间：2024/06/04 Anti-tumor  SHP2  Orthosteric inhibitor  Apoptosis  Bromophenol   JC-010a, a novel selective SHP2 allosteric inhibitor, overcomes RTK/non-RTK-mediated drug resistance in multiple oncogene-addicted cancers 期刊论文  OAI收割 CANCER LETTERS, 2024, 卷号: 582, 页码: 15 作者:  Lu, Xuxiu;  Yu, Rilei;  Li, Zhen;  Yang, Mengke;  Dai, Jiajia   |  收藏  |  浏览/下载：37/0  |  提交时间：2024/04/07 Acquired resistance  Cancer  NSCLC  JC-010a  SHP2   From bench to bedside: current development and emerging trend of KRAS-targeted therapy 期刊论文  OAI收割 ACTA PHARMACOLOGICA SINICA, 2023, 页码: 18 作者:  Chen, Yi;  Liu, Qiu-pei;  Xie, Hua;  Ding, Jian   |  收藏  |  浏览/下载：59/0  |  提交时间：2024/01/16 KRAS mutation  KRAS(G12C) inhibitor  Pan-KRAS inhibitor  SHP2 allosteric inhibitor  SOS1 inhibitor  combination therapy   Synthesis and biological evaluation of 2,5-diaryl-1,3,4-oxadiazole derivatives as novel Src homology 2 domain-containing protein tyrosine phosphatase 2 (SHP2) inhibitors 期刊论文  OAI收割 BIOORGANIC CHEMISTRY, 2021, 卷号: 116, 页码: 13 作者:  Meng, Xiang-Dong;  Gao, Li-Xin;  Wang, Zhi-Jia;  Feng, Bo;  Zhang, Chun   |  收藏  |  浏览/下载：81/0  |  提交时间：2021/12/01 2,5-diphenyl-1,3,4-oxadiazole derivatives  SHP2  Inhibitors  Structure-activity relationships (SAR)   Synthesis of 5-Phenyl-1,3,4-thiadiazole Derivatives and Their Biochemical Evaluation against Src Homology 2 Domain-Containing Protein Tyrosine Phosphatase 1 (SHP1) 期刊论文  OAI收割 CHINESE JOURNAL OF ORGANIC CHEMISTRY, 2021, 卷号: 41, 期号: 8, 页码: 3097-3105 作者:  Yu Lijie;  Feng Bo;  Wang Zhijia;  Gao Lixin;  Zhang Chun   |  收藏  |  浏览/下载：116/0  |  提交时间：2021/11/04 5-phenyl-1,3,4-thiadiazole derivatives  Src homology 2 domain-containing protein tyrosine phosphatase 1 (SHP1)  inhibitors  structure-activity relationships   Discovery of thalidomide-based PROTAC small molecules as the highly efficient SHP2 degraders 期刊论文  OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 218, 页码: 14 作者:  Yang, Xiangbo;  Wang, Zhijia;  Pei, Yuan;  Song, Ning;  Xu, Lei   |  收藏  |  浏览/下载：43/0  |  提交时间：2021/08/17 SHP2 degradation  Proteolysis targeting chimera (PROTAC)  Thalidomide-based heterobifunctional molecules  E3 ubiquitin ligase  CRBN   Allosteric Inhibitors of SHP2: An Updated Patent Review (2015-2020) 期刊论文  OAI收割 CURRENT MEDICINAL CHEMISTRY, 2021, 卷号: 28, 期号: 19, 页码: 3825-3842 作者:  Wu, Jingwei;  Zhang, Huan;  Zhao, Guilong;  Wang, Runling   |  收藏  |  浏览/下载：24/0  |  提交时间：2021/08/17 SHP2 inhibitor  PTPN11 gene  allosteric  cancer  combination therapy  clinical trial