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	Investigating the Metabolic Mechanisms of Butaselen, An Ebselen Analog 期刊论文 OAI收割 CURRENT DRUG METABOLISM, 2022, 卷号: 23, 期号: 11, 页码: 928-939 作者: Tian, Qianqian; Jiang, Jinfang; Yin, Hanwei; Zhang, Yifan; Li, Yilin \| 收藏 \| 浏览/下载：19/0 \| 提交时间：2023/04/10 Butaselen ebselen covalent binding Se-methylation cytosol TPMT
	Apoptosis induction and G2/M arrest of 2-methyl-1,3,6-trihydroxy-9,10-anthraquinone from Rubia yunnanensis in human cervical cancer HeLa cells 期刊论文 OAI收割 PHARMAZIE, 2013, 卷号: 68, 期号: 4, 页码: 293-299 作者: Zeng, Guang-Zhi; Fan, Jun-Ting; Xu, Jun-Ju; Li, Yan; Tan, Ning-Hua 收藏 \| 浏览/下载：36/0 \| 提交时间：2015/05/14 2-Methyl-1,3,6-trihydroxy-9,10-anthraquinone (MTA) one of the major components isolated from the traditional Chinese medicine Rubia yunnanensis exhibited inhibitory activity on the proliferation of several human cancer cell lines. The results from an annexin V-FITC (fluoresein-5-isothiocyanate) apoptosis assay and DNA content analysis showed that MTA exerted cytotoxicity via apoptosis induction and G2/M cell cycle arrest in human cervical carcinoma HeLa cells. Further MTA was found to induce apoptosis of HeLa cells through the mitochondria-mediated pathway. It caused the translocation of Bax to the mitochondria and release of cytochrome c into the cytosol which caused the cleavage of caspase and poly(ADP-ribose) polymerase and finally triggered the apoptosis. Furthermore the p53/p21/Cdc2-cyclin B1 signaling was found related to the G2/M arrest caused by MTA. The over-expression of p21 and down-expression of cyclin B1 caused by MTA inactivated the Cdc2-cyclin B1 complex of G2/M checkpoint and finally caused the G2/M arrest in HeLa cells. This study demonstrated that MTA is a potential anti-cancer component of R. yunnanensis a folk anti-cancer herb used in Yunnan China.
	Distribution of metalloproteins in hepatocellular carcinoma and surrounding tissues 期刊论文 OAI收割 HEPATO-GASTROENTEROLOGY, 2007, 卷号: 54, 期号: 80, 页码: 2291-2296 作者: Liu, YB; Li LN(李丽娜); Gao YX(高愈希); Chen CY(陈春英); Li B(李柏) 收藏 \| 浏览/下载：23/0 \| 提交时间：2016/06/29 hepatocellular carcinoma metalloproteins microsome cytosol synchrotron radiation X-ray fluorescence isoelectric focusing
	Detection of metalloproteins in human liver cytosol by synchrotron radiation X-ray fluorescence after sodium dodecyl sulphate polyacrylamide gel electrophoresis 期刊论文 OAI收割 ANALYTICA CHIMICA ACTA, 2003, 卷号: 485, 期号: 1, 页码: #REF! 作者: Gao YX(高愈希); Chen CY(陈春英); Zhang PQ(章佩群); Chai ZF(柴之芳); He W(何伟) 收藏 \| 浏览/下载：25/0 \| 提交时间：2016/04/12 synchrotron radiation X-ray fluorescence electrophoresis metal-containing proteins human liver cytosol