中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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CAS IR Grid
机构
昆明动物研究所 [3]
上海药物研究所 [1]
昆明植物研究所 [1]
中国科学院大学 [1]
采集方式
OAI收割 [5]
iSwitch采集 [1]
内容类型
期刊论文 [6]
发表日期
2018 [1]
2017 [2]
2016 [1]
2013 [1]
2012 [1]
学科主题
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Accepted Article Preview: Published ahead of advance online publication
期刊论文
OAI收割
NEUROPSYCHOPHARMACOLOGY, 2018, 卷号: 43, 期号: 5, 页码: 1128-1137
作者:
Hong Chang
;
Xiong-Jian Luo
;
Yina Ma
;
Xiao Xiao
;
Ming Li
  |  
收藏
  |  
浏览/下载:69/0
  |  
提交时间:2018/09/28
Major Depressive Disorder
Genome-wide Association Study
Meta-analysis
Pcdh9
Expression
The gene encoding protocadherin 9 (PCDH9), a novel risk factor for major depressive disorder
期刊论文
OAI收割
Neuropsychopharmacology, 2017, 卷号: **, 期号: **, 页码: Epub ahead of print
作者:
Luo JX
;
Li M*
;
Xiao X
;
Yao YG
;
Ma YN
  |  
收藏
  |  
浏览/下载:38/0
  |  
提交时间:2017/10/12
Major Depressive Disorder
Genome-wide Association Study
Meta-analysis
Pcdh9
Expression
SZDB: A Database for Schizophrenia Genetic Research
期刊论文
OAI收割
Schizophrenia Bulletin, 2017, 卷号: 43, 期号: 2, 页码: 459–471
作者:
Wu Y[1,2]
;
Yao YG
;
Luo XJ[*]
收藏
  |  
浏览/下载:49/0
  |  
提交时间:2016/07/29
schizophrenia
genetic study
database
gene expression
integrative analysis
Pooled analysis of genome-wide association studies of cervical intraepithelial neoplasia 3 (cin3) identifies a new susceptibility locus
期刊论文
iSwitch采集
Oncotarget, 2016, 卷号: 7, 期号: 27, 页码: 42216-42224
作者:
Chen, Dan
;
Enroth, Stefan
;
Liu, Han
;
Sun, Yang
;
Wang, Huibo
收藏
  |  
浏览/下载:46/0
  |  
提交时间:2019/05/09
Cervical intraepithelial neoplasia 3
Genome-wide association study
Genetic variants
Expression quantitative trait locus
Human leukocyte antigen
Apoptosis induction and G2/M arrest of 2-methyl-1,3,6-trihydroxy-9,10-anthraquinone from Rubia yunnanensis in human cervical cancer HeLa cells
期刊论文
OAI收割
PHARMAZIE, 2013, 卷号: 68, 期号: 4, 页码: 293-299
作者:
Zeng, Guang-Zhi
;
Fan, Jun-Ting
;
Xu, Jun-Ju
;
Li, Yan
;
Tan, Ning-Hua
收藏
  |  
浏览/下载:42/0
  |  
提交时间:2015/05/14
2-Methyl-1,3,6-trihydroxy-9,10-anthraquinone (MTA)
one of the major components isolated from the traditional
Chinese medicine Rubia yunnanensis
exhibited inhibitory activity on the proliferation of several
human cancer cell lines. The results from an annexin V-FITC (fluoresein-5-isothiocyanate) apoptosis assay
and DNA content analysis showed that MTA exerted cytotoxicity via apoptosis induction and G2/M cell cycle
arrest in human cervical carcinoma HeLa cells. Further
MTA was found to induce apoptosis of HeLa cells
through the mitochondria-mediated pathway. It caused the translocation of Bax to the mitochondria and
release of cytochrome c into the cytosol
which caused the cleavage of caspase and poly(ADP-ribose)
polymerase and finally triggered the apoptosis. Furthermore
the p53/p21/Cdc2-cyclin B1 signaling was
found related to the G2/M arrest caused by MTA. The over-expression of p21 and down-expression of
cyclin B1 caused by MTA inactivated the Cdc2-cyclin B1 complex of G2/M checkpoint and finally caused
the G2/M arrest in HeLa cells. This study demonstrated that MTA is a potential anti-cancer component of
R. yunnanensis
a folk anti-cancer herb used in Yunnan
China.
Ice breaking in GPCR structural biology
期刊论文
OAI收割
ACTA PHARMACOLOGICA SINICA, 2012, 卷号: 33, 期号: 3, 页码: 324-334
作者:
Zhao, Qiang
;
Wu, Bei-li
  |  
收藏
  |  
浏览/下载:16/0
  |  
提交时间:2019/01/08
G-protein-coupled receptors (GPCRs)
expression study
mutagenesis
surfactant
crystallization
bicelle
lipidic cubic phase