机构

• 昆明植物研究所 [1]
• 长春应用化学研究所 [1]
• 兰州化学物理研究所 [1]

采集方式

• OAI收割 [3]

内容类型

• 期刊论文 [3]

发表日期

• 2014 [1]
• 2013 [2]

学科主题

• 药物化学 [1]

筛选

浏览/检索结果: 共3条，第1-3条 帮助 条数/页： 5101520253035404550556065707580859095100 排序方式： 请选择题名升序题名降序提交时间升序提交时间降序作者升序作者降序发表日期升序发表日期降序 Chiral phosphoramide-catalyzed enantioselective synthesis of 2,3'-diindolylarylmethanes from indol-2-yl carbinols and indoles 期刊论文  OAI收割 chemical communications, 2014, 卷号: 50, 期号: 62, 页码: 8605-8608 Qi, Shuai; Liu, Chao-You; Ding, Jin-Ying; Han,Fu-She 收藏  |  浏览/下载：20/0  |  提交时间：2015/03/30 FRIEDEL-CRAFTS REACTIONS  INDUCE APOPTOSIS  CANCER CELLS  1  ALPHA-ALKYLATION  INHIBIT GROWTH  GAMMA AGONISTS  BRONSTED ACID  RECEPTOR  DERIVATIVES  1-BIS(3'-INDOLYL)-1-(P-SUBSTITUTED PHENYL)METHANES   Apoptosis induction and G2/M arrest of 2-methyl-1,3,6-trihydroxy-9,10-anthraquinone from Rubia yunnanensis in human cervical cancer HeLa cells 期刊论文  OAI收割 PHARMAZIE, 2013, 卷号: 68, 期号: 4, 页码: 293-299 作者:  Zeng, Guang-Zhi;  Fan, Jun-Ting;  Xu, Jun-Ju;  Li, Yan;  Tan, Ning-Hua 收藏  |  浏览/下载：44/0  |  提交时间：2015/05/14 2-Methyl-1,3,6-trihydroxy-9,10-anthraquinone (MTA)  one of the major components isolated from the traditional  Chinese medicine Rubia yunnanensis  exhibited inhibitory activity on the proliferation of several  human cancer cell lines. The results from an annexin V-FITC (fluoresein-5-isothiocyanate) apoptosis assay  and DNA content analysis showed that MTA exerted cytotoxicity via apoptosis induction and G2/M cell cycle  arrest in human cervical carcinoma HeLa cells. Further  MTA was found to induce apoptosis of HeLa cells  through the mitochondria-mediated pathway. It caused the translocation of Bax to the mitochondria and  release of cytochrome c into the cytosol  which caused the cleavage of caspase and poly(ADP-ribose)  polymerase and finally triggered the apoptosis. Furthermore  the p53/p21/Cdc2-cyclin B1 signaling was  found related to the G2/M arrest caused by MTA. The over-expression of p21 and down-expression of  cyclin B1 caused by MTA inactivated the Cdc2-cyclin B1 complex of G2/M checkpoint and finally caused  the G2/M arrest in HeLa cells. This study demonstrated that MTA is a potential anti-cancer component of  R. yunnanensis  a folk anti-cancer herb used in Yunnan  China.   异紫堇二酮体内外抗肿瘤活性研究 期刊论文  OAI收割 中国药理学通报, 2013, 卷号: 29, 期号: 6, 页码: 832-836 作者:  卜令娜;  赵剑喜;  李文广;  柳军玺;  刘晔玮 收藏  |  浏览/下载：37/0  |  提交时间：2013/12/26 抗肿瘤  异紫堇二酮  生物碱  活性评价  细胞周期  诱导凋亡  antitumor  isocorydione  alkaloid  activity evaluation  cell cycle  induce apoptosis