中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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CAS IR Grid
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上海药物研究所 [28]
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期刊论文 [55]
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Thioparib inhibits homologous recombination repair, activates the type I IFN response, and overcomes olaparib resistance
期刊论文
OAI收割
EMBO MOLECULAR MEDICINE, 2023, 页码: 24
作者:
Wang, Li-Min
;
Wang, Pingyuan
;
Chen, Xiao-Min
;
Yang, Hui
;
Song, Shan-Shan
  |  
收藏
  |  
浏览/下载:51/0
  |  
提交时间:2023/04/10
homologous recombination repair
olaparib-resistant
PARP inhibitor
PARP7
type I interferons
Discovery and biological evaluation of a new type of dual inhibitors of indoleamine 2,3-dioxygenase 1 and tryptophan 2,3-dioxygenase from ethnomedicinal plant Dactylicapnos scandens
期刊论文
OAI收割
PHYTOCHEMISTRY, 2023, 卷号: 214, 页码: 113794
作者:
Bao,Mei-Fen
;
Yang,Xin-Ni
;
Wu,Jing
;
Liu,Jiang-Xin
;
Cai,Xiang-Hai
  |  
收藏
  |  
浏览/下载:26/0
  |  
提交时间:2024/07/25
Dactylicapnos scandens (D. don) hutch.
Isoquinoline alkaloids
Aporphine-type alkaloids
Dactycapnine a
IDO1/TDO dual inhibitor
APORPHINE ALKALOIDS
N-OXIDE
INFLAMMATION
PATHWAY
THALIPORPHINE
COMPLEXES
CANCER
ROOTS
Novel tetrahydrobenzo[b]thiophen-2-yl)urea derivatives as novel alpha-glucosidase inhibitors: Synthesis, kinetics study, molecular docking, and in vivo anti-hyperglycemic evaluation
期刊论文
OAI收割
BIOORGANIC CHEMISTRY, 2021, 卷号: 115, 页码: 17
作者:
Xie, Hong-Xu
;
Zhang, Juan
;
Li, Yue
;
Zhang, Jin-He
;
Liu, Shan-Kui
  |  
收藏
  |  
浏览/下载:81/0
  |  
提交时间:2021/11/04
Tetrahydrobenzo[b]thiophen-2-yl)urea
alpha-Glucosidase inhibitors
Non-competitive inhibitor
Molecular docking
Anti-hyperglycaemic activity
Type 2 diabetes
Combined treatment with FABP4 inhibitor ameliorates rosiglitazone-induced liver steatosis in obese diabetic db/db mice
期刊论文
OAI收割
BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY, 2021, 页码: 10
作者:
Chen, Meng-Ting
;
Huang, Jun-Shang
;
Gao, Ding-Ding
;
Li, Ying-Xia
;
Wang, He-Yao
  |  
收藏
  |  
浏览/下载:31/0
  |  
提交时间:2021/08/17
combined treatment
FABP4 inhibitor
liver steatosis
obese type 2 diabetes
rosiglitazone
Characterization and function analysis of a Kazal-type serine proteinase inhibitor in the red claw crayfish Cherax quadricarinatus
期刊论文
OAI收割
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY, 2021, 卷号: 114, 页码: 10
作者:
Wang, Yan
;
Wang, Baojie
;
Liu, Mei
;
Jiang, Keyong
;
Wang, Mengqiang
  |  
收藏
  |  
浏览/下载:36/0
  |  
提交时间:2021/04/12
Cherax quadricarinatus
Kazal-type serine proteinase inhibitor
Innate immunity
Identification and Characterization of ShSPI, a Kazal-Type Elastase Inhibitor from the Venom of Scolopendra Hainanum
期刊论文
OAI收割
TOXINS, 2019, 卷号: 11, 期号: 12, 页码: 13
作者:
Luan, Ning
;
Zhao, Qiyu
;
Duan, Zilei
;
Ji, Mengyao
;
Xing, Meichen
  |  
收藏
  |  
浏览/下载:25/0
  |  
提交时间:2020/03/18
centipede
kazal-type inhibitor
human neutrophils elastase
ShSPI
Saxagliptin alters bile acid profiles and yields metabolic benefits in drug-naive overweight or obese type 2 diabetes patient
期刊论文
OAI收割
JOURNAL OF DIABETES, 2019, 页码: 11
作者:
Li, Wen
;
Liu, Ruixin
;
Li, Xuelin
;
Tao, Bei
;
Zhai, Nan
  |  
收藏
  |  
浏览/下载:87/0
  |  
提交时间:2019/12/02
bile acids
dipeptidyl peptidase-4 inhibitor
obesity
saxagliptin
type 2 diabetes
Antiproliferative Aspidosperma-Type Monoterpenoid Indole Alkaloids from Bousigonia mekongensis Inhibit Tubulin Polymerization
期刊论文
OAI收割
MOLECULES, 2019, 卷号: 24, 期号: 7, 页码: 10
作者:
Zhang, Yu
;
Goto, Masuo
;
Oda, Akifumi
;
Hsu, Pei-Ling
;
Guo, Ling-Li
  |  
收藏
  |  
浏览/下载:81/0
  |  
提交时间:2019/07/29
aspidosperma-type
monoterpenoid indole alkaloids
antiproliferative activity
tubulin inhibitor
Bousigonia mekongensis
Saxagliptin alters bile acid profiles and yields metabolic benefits in drug-naive overweight or obese type 2 diabetes patient
期刊论文
OAI收割
JOURNAL OF DIABETES, 2019, 卷号: 11, 期号: 12, 页码: 982-992
作者:
Li, Wen
;
Liu, Ruixin
;
Li, Xuelin
;
Tao, Bei
;
Zhai, Nan
  |  
收藏
  |  
浏览/下载:17/0
  |  
提交时间:2020/12/09
bile acids
dipeptidyl peptidase-4 inhibitor
obesity
saxagliptin
type 2 diabetes
Design, synthesis and biological evaluation of novel pyrimidinedione derivatives as DPP-4 inhibitors
期刊论文
OAI收割
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2018, 卷号: 28, 期号: 12, 页码: 2131-2135
作者:
Li, Ning
;
Wang, Li-Jun
;
Jiang, Bo
;
Guo, Shu-Ju
;
Li, Xiang-Qian
  |  
收藏
  |  
浏览/下载:66/0
  |  
提交时间:2019/08/21
Pyrimidinedionederivatives
DPP-4 inhibitor
Molecular hybrid
SARs
Type 2 diabetes