机构

• 上海药物研究所 [11]
• 合肥物质科学研究院 [3]

采集方式

• OAI收割 [14]

内容类型

• 期刊论文 [14]

发表日期

• 2022 [2]
• 2017 [4]
• 2014 [2]
• 2013 [1]
• 2009 [1]
• 2007 [2]
• 更多

学科主题

• Biochemist... [1]
• Cell Biolo... [1]

筛选

浏览/检索结果: 共14条，第1-10条 帮助 条数/页： 5101520253035404550556065707580859095100 排序方式： 请选择题名升序题名降序提交时间升序提交时间降序作者升序作者降序发表日期升序发表日期降序 Discovery of N-(3-bromo-1H-indol-5-yl)-quinazolin-4-amine as an effective molecular skeleton to develop reversible/irreversible pan-HER inhibitors 期刊论文  OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2022, 卷号: 233, 页码: 13 作者:  Tang, Qidong;  Peng, Ting;  Hu, Jie;  Zhang, Tao;  Chen, Pengqin   |  收藏  |  浏览/下载：43/0  |  提交时间：2022/08/16 Reversible  irreversible pan-HER inhibitor  Quinazolin-4-amine derivatives  Anti-tumor  Structure-activity relationship   CHMFL-26 is a highly potent irreversible HER2 inhibitor for use in the treatment of HER2-positive and HER2-mutant cancers 期刊论文  OAI收割 ACTA PHARMACOLOGICA SINICA, 2022 作者:  Cao, Jiang-yan;  Qi, Shuang;  Wu, Hong;  Wang, Ao-li;  Liu, Qing-wang   |  收藏  |  浏览/下载：69/0  |  提交时间：2022/03/28 HER2  breast cancers  gastric cancers  irreversible inhibitor  drug resistance   Discovery and development of pyrotinib: A novel irreversible EGFR/HER2 dual tyrosine kinase inhibitor with favorable safety profiles for the treatment of breast cancer 期刊论文  OAI收割 EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2017, 卷号: 110, 页码: 51-61 作者:  Li, Xin;  Yang, Changyong;  Wan, Hong;  Zhang, Ge;  Feng, Jun   |  收藏  |  浏览/下载：148/0  |  提交时间：2019/01/08 Pyrotinib  HER2-postive breast cancer  Irreversible EGFR/HER2 dual tyrosine kinase  inhibitor  Preclinical  Clinical  Safety  Drug metabolism   Structure-activity relationship investigation for benzonaphthyridinone derivatives as novel potent Bruton's tyrosine kinase (BTK) irreversible inhibitors 期刊论文  OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2017, 卷号: 137, 页码: 545-557 作者:  Wang, Beilei;  Deng, Yuanxin;  Chen, Yongfei;  Yu, Kailin;  Wang, Aoli   |  收藏  |  浏览/下载：48/0  |  提交时间：2018/08/16 Btk  Kinase Inhibitor  Irreversible Inhibitor  Structure-activity Relationship  B-cell Lymphoma   Discovery of N-(3-(5-((3-acrylamido-4-(morpholine-4-carbonyl) phenyl)amino)-1-methyl-6-oxo-1,6-dihydropyridin-3-yl)-2-methylphenyl)-4-(tert-butyl)benzamide (CHMFL-BTK-01) as a highly selective irreversible Bruton's tyrosine kinase (BTK) inhibitor 期刊论文  OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2017, 卷号: 131, 页码: 107-125 作者:  Liang, Qianmao;  Chen, Yongfei;  Yu, Kailin;  Chen, Cheng;  Zhang, Shouxiang   |  收藏  |  浏览/下载：44/0  |  提交时间：2018/07/26 Btk  Irreversible Inhibitor  Kinase Inhibitor  Structure-activity Relationship  B-cell Lymphoma   A structure-guided optimization of pyrido[2,3-d]pyrimidin-7-ones as selective inhibitors of EGFR(L858R/T790M) mutant with improved pharmacokinetic properties 期刊论文  OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2017, 卷号: 126, 页码: 1107-1117 作者:  Yu, Lei;  Huang, Minhao;  Xu, Tianfeng;  Tong, Linjiang;  Yan, Xiao-e   |  收藏  |  浏览/下载：40/0  |  提交时间：2019/01/08 EGFR(T790M) mutant  Pyrido[2,3-d]pyrimidin-7-ones  Pharmacokinetic property  NSCLC  Irreversible inhibitor   Design, synthesis and biological evaluation of novel 6-alkenylamides substituted of 4-anilinothieno[2,3-d]pyrimidines as irreversible epidermal growth factor receptor inhibitors 期刊论文  OAI收割 BIOORGANIC & MEDICINAL CHEMISTRY, 2014, 卷号: 22, 期号: 7, 页码: 2366-2378 作者:  Ji, Xun;  Peng, Ting;  Zhang, Xu;  Li, Jian;  Yang, Wei   |  收藏  |  浏览/下载：45/0  |  提交时间：2019/01/08 Irreversible EGFR inhibitor  EGFR T790M/L858R  Thieno[2,3-d]pyrimidines   A phase I study of AST1306, a novel irreversible EGFR and HER2 kinase inhibitor, in patients with advanced solid tumors 期刊论文  OAI收割 JOURNAL OF HEMATOLOGY & ONCOLOGY, 2014, 卷号: 7 作者:  Zhang, Jian;  Cao, Junning;  Li, Jin;  Zhang, Yifan;  Chen, Zhiyu   |  收藏  |  浏览/下载：25/0  |  提交时间：2019/01/08 AST1306  ErbB family  Irreversible tyrosine kinase inhibitor  Phase I   Design, synthesis and biological evaluation of novel 4-anilinoquinazolines with C-6 urea-linked side chains as inhibitors of the epidermal growth factor receptor 期刊论文  OAI收割 BIOORGANIC & MEDICINAL CHEMISTRY, 2013, 卷号: 21, 期号: 24, 页码: 7988-7998 作者:  Zhang, Xu;  Peng, Ting;  Ji, Xun;  Li, Jian;  Tong, Linjiang   |  收藏  |  浏览/下载：39/0  |  提交时间：2019/01/08 EGFR inhibitor  EGFR T790M/L858R  Binding mode  Irreversible EGFR inhibitor   LGH00031, a novel ortho-quinonoid inhibitor of cell division cycle 25B, inhibits human cancer cells via ROS generation 期刊论文  OAI收割 ACTA PHARMACOLOGICA SINICA, 2009, 卷号: 30, 期号: 9, 页码: 1359-1368 作者:  Zhou, Yu-bo;  Feng, Xu;  Wang, Li-na;  Du, Jun-qing;  Zhou, Yue-yang   |  收藏  |  浏览/下载：25/0  |  提交时间：2019/01/08 LGH00031  ortho-quinone  CDC25B  irreversible inhibitor  ROS