中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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De Novo Design of Structure-Tunable Multivalent Targeting Chimeras for Tumor-Targeted PD-L1 Degradation and Potentiated Cancer Immunotherapy
期刊论文
OAI收割
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2025, 页码: 17
作者:
Zhou, Huiling
;
Hou, Bo
;
Shan, Yiming
;
Huang, Lujia
;
Chen, Fangmin
  |  
收藏
  |  
浏览/下载:1/0
  |  
提交时间:2025/06/23
Combinatory therapy, Immune checkpoint blockade, Multivalent targeting chimeras
Tumor microenvironment
Tumor-specific PD-L1 degradation
Multi-gene metabolic engineering of
Pichia pastoris
to synthesize ectoine
期刊论文
OAI收割
JOURNAL OF BIOSCIENCE AND BIOENGINEERING, 2025, 卷号: 139, 期号: 5, 页码: 347-353
作者:
Zhang, Shuai
;
Cheng, Bingjie
;
Liao, Qing
;
Huang, Xuewu
;
Mi, Mengjiao
  |  
收藏
  |  
浏览/下载:3/0
  |  
提交时间:2025/05/27
Pichia pastoris
Ectoine
ectABC
Metabolic engineering
L-Aspartate-beta-semialdehyde
Dynamic Cap-Mediated Substrate Access and Potent Inhibitor Design of Monkeypox Virus I7L Protease
期刊论文
OAI收割
ADVANCED SCIENCE, 2025, 页码: 13
作者:
Su, Haixia
;
Wu, Guoqing
;
Xiong, Muya
;
Wang, Yuhang
;
Cao, Junyuan
  |  
收藏
  |  
浏览/下载:3/0
  |  
提交时间:2025/05/27
covalent inhibitors
I7L protease
monkeypox virus
protein structures
substrate proteolysis
Jatrophane and ingenane diterpenoids with anti-inflammatory activity from
Euphorbia esula
期刊论文
OAI收割
PHYTOCHEMISTRY, 2025, 卷号: 232, 页码: 13
作者:
Li, Yu-Peng
;
Li, Ying
;
Gao, Wen-Jing
;
Fang, Chu-Hong
;
Lv, Ming-Jun
  |  
收藏
  |  
浏览/下载:63/0
  |  
提交时间:2025/04/01
Euphorbia esula L.
Euphorbiaceae
Diterpenoid
Anti-inflammatory
NF-kappa B/MAPK
Nrf2/HO-1
Interface and microstructure of heterogeneous laminated steels upon shear loading
期刊论文
OAI收割
JOURNAL OF ALLOYS AND COMPOUNDS, 2025, 卷号: 1020, 页码: 13
作者:
Liu, Yanke
;
Wang, Wei
;
Yang, Muxin
;
Jiao, Sihai
;
Zhou, Lingling
  |  
收藏
  |  
浏览/下载:18/0
  |  
提交时间:2025/04/14
Multilayer laminates of 304L stainless steel
low C steel and medium-Mn steel
Dynamic properties
Interface effects
Strain hardening
Martensitic transformation
Geriatric Nutritional Risk Index is an effective prognostic predictor for metastatic/recurrent or unresectable esophageal cancer receiving immunotherapy
期刊论文
OAI收割
JOURNAL OF GASTROINTESTINAL ONCOLOGY, 2025, 卷号: 16, 期号: 1, 页码: 22
作者:
Wang, Bei
;
Wang, Zixuan
;
Xu, Chuanhai
;
Wang, Yueqin
;
Gao, Honglan
  |  
收藏
  |  
浏览/下载:1/0
  |  
提交时间:2025/05/27
Geriatric Nutritional Risk Index (GNRI)
esophageal squamous cell carcinoma (ESCC)
immune checkpoint inhibitors (ICIs)
programmed cell death ligand 1 (PD-L1)
Silybin Cocrystals with Improved Solubility and Bioavailability
期刊论文
OAI收割
PHARMACEUTICALS, 2025, 卷号: 18, 期号: 1, 页码: 11
作者:
Zhu, Bingqing
;
Ding, Zhenfeng
;
Rong, Xiaoyi
;
Li, Shengqiang
;
Mei, Xuefeng
  |  
收藏
  |  
浏览/下载:16/0
  |  
提交时间:2025/04/01
silybin
cocrystal
solubility
bioavailability
L-proline
Berberine Derivative B68 Promotes Tumor Immune Clearance by Dual-Targeting BMI1 for Senescence Induction and CSN5 for PD-L1 Degradation
期刊论文
OAI收割
ADVANCED SCIENCE, 2024, 页码: 21
作者:
Hu, Hongmei
;
Wang, Qun
;
Yu, Dianping
;
Tao, Xiaoyu
;
Guo, Mengmeng
  |  
收藏
  |  
浏览/下载:11/0
  |  
提交时间:2025/02/28
BMI1
colorectal cancer
CSN5
PD-L1
tumor cell senescence
Excess supply of sulfur mitigates thallium toxicity to rice (
Oryza
sativa
L.) growth in hydroponic experiment
期刊论文
OAI收割
SCIENCE OF THE TOTAL ENVIRONMENT, 2024, 卷号: 954, 页码: 10
作者:
Zhao, Jiayin
;
Deng, Hongmei
;
Song, Zhiyi
;
Wu, Shishi
;
Liang, Bixia
  |  
收藏
  |  
浏览/下载:8/0
  |  
提交时间:2025/04/01
Thallium
Rice (Oryza sativa L.)
Sulfur supply
Iron plaque
Hydroponic experiment
Assessing the physiological responses and uptake patterns of lanthanum and yttrium in rice and Phytolacca americana L.
期刊论文
OAI收割
PROCESS SAFETY AND ENVIRONMENTAL PROTECTION, 2024, 卷号: 191, 页码: 249-258
作者:
Wang, Mingyuan
;
Wang, Yazhu
;
Wang, Lingqing
;
Dai, Lijun
;
Zhang, Haiyan
  |  
收藏
  |  
浏览/下载:21/0
  |  
提交时间:2024/10/21
Rice
Lanthanum
Yttrium
Phytolacca americana L.
Physiological response
Structural Equation Modeling (SEM)