中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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CAS IR Grid
机构
合肥物质科学研究院 [3]
苏州纳米技术与纳米仿... [1]
昆明植物研究所 [1]
昆明动物研究所 [1]
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OAI收割 [6]
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期刊论文 [6]
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2021 [1]
2020 [1]
2019 [1]
2013 [1]
2011 [1]
2007 [1]
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Editorial: The Role of Different Subcellular Organelles in DNA Damage Response
期刊论文
OAI收割
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, 2021, 卷号: 9
作者:
Zhao, Guoping
  |  
收藏
  |  
浏览/下载:32/0
  |  
提交时间:2022/01/10
DNA damage repair
subcellular organelles
mitochondria
lysosomes
crosstalk
Genotoxicity of microcystin-LR in mammalian cells: Implication from peroxynitrite produced by mitochondria
期刊论文
OAI收割
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY, 2020, 卷号: 195
作者:
Wang, Xiaofei
;
Li, Yintao
;
Xiao, Hourong
;
Zhang, Min
;
Bao, Teng
  |  
收藏
  |  
浏览/下载:50/0
  |  
提交时间:2020/11/26
Microcystin-LR
DNA damage
Peroxynitrite
Mitochondria
Nuclear factor (erythroid-derived 2)-like 2 antioxidative response mitigates cytoplasmic radiation-induced DNA double-strand breaks
期刊论文
OAI收割
CANCER SCIENCE, 2019, 卷号: 110, 期号: 2, 页码: 686-696
作者:
Wang, Jun
;
Konishi, Teruaki
  |  
收藏
  |  
浏览/下载:18/0
  |  
提交时间:2020/05/21
cytoplasm
double-strand DNA break
mitochondria
radiation biology
Apoptosis induction and G2/M arrest of 2-methyl-1,3,6-trihydroxy-9,10-anthraquinone from Rubia yunnanensis in human cervical cancer HeLa cells
期刊论文
OAI收割
PHARMAZIE, 2013, 卷号: 68, 期号: 4, 页码: 293-299
作者:
Zeng, Guang-Zhi
;
Fan, Jun-Ting
;
Xu, Jun-Ju
;
Li, Yan
;
Tan, Ning-Hua
收藏
  |  
浏览/下载:44/0
  |  
提交时间:2015/05/14
2-Methyl-1,3,6-trihydroxy-9,10-anthraquinone (MTA)
one of the major components isolated from the traditional
Chinese medicine Rubia yunnanensis
exhibited inhibitory activity on the proliferation of several
human cancer cell lines. The results from an annexin V-FITC (fluoresein-5-isothiocyanate) apoptosis assay
and DNA content analysis showed that MTA exerted cytotoxicity via apoptosis induction and G2/M cell cycle
arrest in human cervical carcinoma HeLa cells. Further
MTA was found to induce apoptosis of HeLa cells
through the mitochondria-mediated pathway. It caused the translocation of Bax to the mitochondria and
release of cytochrome c into the cytosol
which caused the cleavage of caspase and poly(ADP-ribose)
polymerase and finally triggered the apoptosis. Furthermore
the p53/p21/Cdc2-cyclin B1 signaling was
found related to the G2/M arrest caused by MTA. The over-expression of p21 and down-expression of
cyclin B1 caused by MTA inactivated the Cdc2-cyclin B1 complex of G2/M checkpoint and finally caused
the G2/M arrest in HeLa cells. This study demonstrated that MTA is a potential anti-cancer component of
R. yunnanensis
a folk anti-cancer herb used in Yunnan
China.
Luminescent Peptide Labeling Based on a Histidine-Binding Iridium(III) Complex for Cell Penetration and Intracellular Targeting Studies
期刊论文
OAI收割
CHEMISTRY-A EUROPEAN JOURNAL, 2011, 卷号: 17, 期号: 29, 页码: 8028-8032
作者:
Jia, JL (贾俊丽)
;
Fei, H (费浩)
收藏
  |  
浏览/下载:26/0
  |  
提交时间:2012/08/24
PROTEIN
MITOCHONDRIA
DELIVERY
NANOPARTICLES
PROBES
DNA
Molecular identification and phylogenetic position of Cuora yunnanensis
期刊论文
OAI收割
CHINESE SCIENCE BULLETIN, 2007, 卷号: 52, 期号: 23, 页码: 3305-3309
作者:
He J
;
Zhou T
;
Rao DQ
;
Zhang YP[*]
收藏
  |  
浏览/下载:21/0
  |  
提交时间:2016/10/08
Cuora yunnanensis
mitochondria DNA
conservation