机构

• 上海药物研究所 [13]
• 化学研究所 [2]
• 过程工程研究所 [2]
• 武汉物理与数学研究所 [2]
• 金属研究所 [1]
• 福建物质结构研究所 [1]
• 更多

采集方式

• OAI收割 [29]

内容类型

• 期刊论文 [29]

发表日期

• 2025 [1]
• 2024 [1]
• 2023 [3]
• 2021 [1]
• 2020 [1]
• 2019 [1]
• 更多

学科主题

• Biochemist... [1]
• Chemistry [1]
• Neuroscien... [1]
• Physiology [1]
• 物理化学与绿色催化 [1]

筛选

浏览/检索结果: 共29条，第1-10条 帮助 条数/页： 5101520253035404550556065707580859095100 排序方式： 请选择题名升序题名降序提交时间升序提交时间降序作者升序作者降序发表日期升序发表日期降序 Design, synthesis and pharmacological evaluation of 1,2,3,4-tetrahydrobenzofuro[2,3-c] pyridine derivatives as p21-activated kinase 4 inhibitors for treatment of pancreatic cancer 期刊论文  OAI收割 ACTA PHARMACEUTICA SINICA B, 2025, 卷号: 15, 期号: 1, 页码: 438-466 作者:  Li, Yang;  Fang, Yan;  Chen, Xiaoyu;  Tong, Linjiang;  Feng, Fang   |  收藏  |  浏览/下载：12/0  |  提交时间：2025/04/01 P21-activated kinase 4  Tetrahydrobenzofuro[2  3-c]pyridine  Structure-activity relationship  Allosteric inhibitor  Pharmacokinetics properties  Kinase selectivity  Pancreatic cancer  Immune infiltration   Functional characterization, structural basis, and protein engineering of a rare flavonoid 2'-O-glycosyltransferase from Scutellaria baicalensis 期刊论文  OAI收割 ACTA PHARMACEUTICA SINICA B, 2024, 卷号: 14, 期号: 8, 页码: 3746-3759 作者:  Wang, Zilong;  Du, Xueqing;  Ye, Guo;  Wang, Haotian;  Liu, Yizhan   |  收藏  |  浏览/下载：92/0  |  提交时间：2024/09/26 Glycosyltransferase  Regio-selectivity  Crystal structure  De-glycosylation  Catalytic mechanisms   Reversal of subtype-selectivity and function by the introduction of a para-benzamidyl substituent to N-cyclopropylmethyl nornepenthone 期刊论文  OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2023, 卷号: 258, 页码: 15 作者:  Kong, Linghui;  Ning, Kuan;  Liu, Xiao;  Lu, Jiashuo;  Chen, Baiyu   |  收藏  |  浏览/下载：38/0  |  提交时间：2023/10/17 N-cyclopropylmethyl nornepenthone derivatives  derivatives  Structure-activity relationship  MOR antagonist  Functional reversal  Reversal of subtype-selectivity  Opioid use disorder   Discovery of seven-membered ring berberine analogues as highly potent and specific hCES2A inhibitors 期刊论文  OAI收割 CHEMICO-BIOLOGICAL INTERACTIONS, 2023, 卷号: 378, 页码: 11 作者:  Yang, Yun;  Xiong, Yuan;  Zhu, Guanghao;  Sun, Mengru;  Zou, Kun   |  收藏  |  浏览/下载：34/0  |  提交时间：2023/10/17 Human carboxylesterase 2 (hCES2A)  Berberine analogues  Structure -activity relationships (SAR)  Inhibition kinetics  Selectivity   Optimization of potent, selective and orally bioavailable biphenyl scaffold as FABP4 inhibitors for anti-inflammation 期刊论文  OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2023, 卷号: 253, 页码: 16 作者:  He, Yulong;  Li, Shunyi;  Zhu, Yueyue;  Wang, Yujie;  Chen, Yuqi   |  收藏  |  浏览/下载：79/0  |  提交时间：2023/10/17 Structure-activity relationship  FABP4 inhibitor  Biphenyl scaffold  Selectivity  Oral bioavailability  Anti-inflammation   Discovery of pseudolaric acid A as a new Hsp90 inhibitor uncovers its potential anticancer mechanism 期刊论文  OAI收割 BIOORGANIC CHEMISTRY, 2021, 卷号: 112, 页码: 104963 作者:  Liu,Jiangxin;  Wu,Xing-De;  Li,Wenyan;  Yuan,Zaifeng;  Yang,Kun   |  收藏  |  浏览/下载：26/0  |  提交时间：2022/04/02 Pseudolaric acid A  Hsp90 inhibitor  Apoptosis  NMR  Structure-activity relationship  Photoaffinity-based probe  Protein-ligand interaction  MOLECULAR CHAPERONE  PROTEIN  TARGET  CANCER  KINASE  NMR  IDENTIFICATION  SELECTIVITY  BINDING  DESIGN   An oxygen vacancy-rich two-dimensional Au/TiO2 hybrid for synergistically enhanced electrochemical N2 activation and reduction 期刊论文  OAI收割 Journal of Materials Chemistry A, 2020, 卷号: 8, 期号: 14, 页码: 6586-6596 作者:  Zhao, Sen;  Liu, Han-Xuan;  Qiu, Yu;  Liu, Shuang-Quan;  Diao, Jin-Xiang   |  收藏  |  浏览/下载：68/0  |  提交时间：2021/09/06 Gold compounds  Ammonia  Catalyst selectivity  Chemical activation  Electrocatalysts  Electronic structure  Nitrogen  Oxide minerals  Oxygen  Oxygen vacancies  Reduction  Titanium dioxide  Electrocatalytic activity  Electron  donating effects  Faradaic efficiencies  Nitrogen reduction  Rate  limiting steps  Reversible hydrogen electrodes  Technical challenges  Theoretical calculations   Discovery of a series of dimethoxybenzene FGFR inhibitors with 5H-pyrrolo[2,3-b]pyrazine scaffold: structure-activity relationship, crystal structural characterization and and in vivo study 期刊论文  OAI收割 ACTA PHARMACEUTICA SINICA B, 2019, 卷号: 9, 期号: 2, 页码: 351-368 作者:  Wei, Peng;  Liu, Bo;  Wang, Ruifeng;  Gao, Yinglei;  Li, Lanlan   |  收藏  |  浏览/下载：52/0  |  提交时间：2020/07/01 Fibroblast growth factor  Tyrosine kinase receptor  Structure-based  Crystallography  Selectivity  Hybrid  5-Hydrosulfonyl-5H- pyrrolo[2.3-b]pyrazine  Inhibitor   Discovery and synthesis of 6,7,8,9-tetrahydro-5H-pyrido[4,3-c]azepin-5-one-based novel chemotype CCR2 antagonists via scaffold hopping strategy 期刊论文  OAI收割 BIOORGANIC & MEDICINAL CHEMISTRY, 2018, 卷号: 26, 期号: 12, 页码: 3559-3572 作者:  Qin, Li-Huai;  Wang, Zhi-Long;  Xie, Xin;  Long, Ya-Qiu   |  收藏  |  浏览/下载：42/0  |  提交时间：2019/01/08 6,7,8,9-Tetrahydro-5H-pyrido[43-c]azepin-5-one  3,4-Dihydro-2,6-naphthyridin-1(2H)-one  CCR2 antagonist  Scaffold hopping  Structure-activity relationship  Selectivity of CCR2 over CCR5   Characterization and structure-activity relationship studies of flavonoids as inhibitors against human carboxylesterase 2 期刊论文  OAI收割 BIOORGANIC CHEMISTRY, 2018, 卷号: 77, 页码: 320-329 作者:  Zou, Li-Wei;  Weng, Zi-Miao;  Ge, Guang-Bo;  Dou, Tong-Yi;  Wang, Ping   |  收藏  |  浏览/下载：35/0  |  提交时间：2019/06/20 Flavonoids  Human Carboxylesterase 2 (Hce2)  Structure-inhibition Relationships  Selectivity  Inhibition Mechanism