中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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CAS IR Grid
机构
上海药物研究所 [75]
采集方式
OAI收割 [75]
内容类型
期刊论文 [75]
发表日期
2024 [3]
2023 [6]
2022 [3]
2021 [7]
2019 [6]
2018 [3]
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Pharmacolo... [1]
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专题:上海药物研究所
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New chromone derivatives bearing thiazolidine-2,4-dione moiety as potent PTP1B inhibitors: Synthesis and biological activity evaluation
期刊论文
OAI收割
BIOORGANIC CHEMISTRY, 2024, 卷号: 143, 页码: 9
作者:
Zheng, Yingying
;
Lu, Li
;
Li, Mengyue
;
Xu, Dehua
;
Zhang, Laishun
  |  
收藏
  |  
浏览/下载:8/0
  |  
提交时间:2024/01/26
Chromone
Thiazolidine-2
4-dione
Protein tyrosine phosphatase 1B
Inhibitors
Discovery of a potent and selective covalent threonine tyrosine kinase (TTK) inhibitor
期刊论文
OAI收割
BIOORGANIC CHEMISTRY, 2024, 卷号: 143, 页码: 16
作者:
Sun, Yaoliang
;
Chen, Zhiwen
;
Liu, Guobin
;
Chen, Xiaoai
;
Shi, Zihan
  |  
收藏
  |  
浏览/下载:12/0
  |  
提交时间:2024/03/25
Inhibitor
Cancer
Threonine tyrosine kinase (TTK)
Covalent
Reversible SAHH inhibitor ameliorates MIA-induced osteoarthritis of rats through suppressing MEK/ERK pathway
期刊论文
OAI收割
BIOMEDICINE & PHARMACOTHERAPY, 2024, 卷号: 170, 页码: 6
作者:
Fan, Shu-Hui
;
Chang, Yuan
;
Xiong, Xiao-Yu
;
Xiang, Mai
;
Yuan, Wen-Long
  |  
收藏
  |  
浏览/下载:11/0
  |  
提交时间:2024/02/27
DZ2002
Osteoarthritis
Osteoclast
Bone resorption
Otilonium Bromide acts as a selective USP28 inhibitor and exhibits cytotoxic activity against multiple human cancer cell lines
期刊论文
OAI收割
BIOCHEMICAL PHARMACOLOGY, 2023, 卷号: 215, 页码: 14
作者:
Xu, Zhuo
;
Wang, Hui
;
Meng, Qian
;
Ding, Yiluan
;
Zhu, Mengying
  |  
收藏
  |  
浏览/下载:11/0
  |  
提交时间:2023/10/17
Otilonium Bromide
Deubiquitinase
USP28
Selective inhibitor
DZ2002 alleviates corneal angiogenesis and inflammation in rodent models of dry eye disease via regulating STAT3-PI3KAkt-NF-kappa B pathway
期刊论文
OAI收割
ACTA PHARMACOLOGICA SINICA, 2023, 页码: 14
作者:
Wu, Chun-mei
;
Mao, Jia-wen
;
Zhu, Jin-zhi
;
Xie, Can-can
;
Yao, Jia-ying
  |  
收藏
  |  
浏览/下载:15/0
  |  
提交时间:2023/10/17
dry eye disease
DZ2002
corneal angiogenesis
immunomodulatory function
NF-kappa B
ophthalmic therapy
Design, synthesis and biological evaluation of salicylanilides as novel allosteric inhibitors of human pancreatic lipase
期刊论文
OAI收割
BIOORGANIC & MEDICINAL CHEMISTRY, 2023, 卷号: 91, 页码: 11
作者:
Zhao, Yitian
;
Zhang, Min
;
Hou, Xudong
;
Han, Jiaxin
;
Qin, Xiaoya
  |  
收藏
  |  
浏览/下载:14/0
  |  
提交时间:2023/10/17
Salicylanilide
hPL inhibitor
Structure -activity relationship
Anti -obesity
An ATG4B inhibitor blocks autophagy and sensitizes Sorafenib inhibition activities in HCC tumor cells
期刊论文
OAI收割
BIOORGANIC & MEDICINAL CHEMISTRY, 2023, 卷号: 84, 页码: 117262
作者:
Xie, Yanqiu
;
Fan, Shijie
;
Ni, Dongxuan
;
Wan, Wei
;
Xu, Pan
  |  
收藏
  |  
浏览/下载:3/0
  |  
提交时间:2024/03/27
ATG4B inhibitor
DC-ATG4in
Sorafenib
Hepatocellular Carcinoma
Combination therapy
Thimerosal, a competitive thioredoxin reductase 1 (TrxR1) inhibitor discovered via high-throughput screening
期刊论文
OAI收割
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2023, 卷号: 650, 页码: 117-122
作者:
Ni, Yicheng
;
Luo, Zhongyuan
;
Lv, Yixin
;
Ma, Shuyuan
;
Luo, Cheng
  |  
收藏
  |  
浏览/下载:18/0
  |  
提交时间:2023/10/17
Thioredoxin reductase 1 inhibitor
Chemical probe
High -throughput screening
Thimerosal
Selective Covalent Targeting of Pyruvate Kinase M2 Using Arsenous Warheads
期刊论文
OAI收割
JOURNAL OF MEDICINAL CHEMISTRY, 2023, 卷号: 66, 期号: 4, 页码: 2608-2621
作者:
Wang, Jingyao
;
Zhou, Shaoqing
;
Cheng, Yan
;
Cheng, Lin
;
Qin, Ying
  |  
收藏
  |  
浏览/下载:4/0
  |  
提交时间:2024/03/27
The discovery of a non-competitive GOT1 inhibitor, hydralazine hydrochloride, via a coupling reaction-based high-throughput screening assay
期刊论文
OAI收割
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2022, 卷号: 73, 页码: 6
作者:
Wu, Qiqi
;
Sun, Zhongya
;
Chen, Zhifeng
;
Liu, Jingqiu
;
Ding, Hong
  |  
收藏
  |  
浏览/下载:55/0
  |  
提交时间:2022/08/30
Glutamate oxaloacetate transaminase 1
Inhibitor
Hydralazine hydrochloride
High -throughput screening