中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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上海药物研究所 [30]
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Identification of [1,2,4]Triazolo[4,3-a]pyrazine PARP1 inhibitors with overcome acquired resistance activities
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2023, 卷号: 259, 页码: 19
作者:
Wang, Pingyuan
;
Zhu, Wen-Ting
;
Wang, Yajing
;
Song, Shan-Shan
;
Xi, Yong
  |  
收藏
  |  
浏览/下载:58/0
  |  
提交时间:2023/10/17
PARP1 inhibitor
Synthetic lethality
Drug resistance
Anticancer
Structure -activity relationship
Genomic and transcriptomic profiling indicates the prognosis significance of mutational signature for TMB-high subtype in Chinese patients with gastric cancer
期刊论文
OAI收割
JOURNAL OF ADVANCED RESEARCH, 2023, 卷号: 51, 页码: 121-134
作者:
Cheng, Yanan
;
Bu, Dechao
;
Zhang, Qiaoling
;
Sun, Rebecca
;
Lyle, Stephen
  |  
收藏
  |  
浏览/下载:6/0
  |  
提交时间:2023/12/04
Gastric cancer
Comprehensive genomic profiling
TMB
Mutational signature
Tumor metabolism
YCH1899, a Highly Effective Phthalazin-1(2H)-one Derivative That Overcomes Resistance to Prior PARP Inhibitors
期刊论文
OAI收割
JOURNAL OF MEDICINAL CHEMISTRY, 2023, 页码: 20
作者:
Sun, Yuting
;
Yang, Hui
;
Yuan, Jiaqi
;
Wang, Limin
;
Song, Shanshan
  |  
收藏
  |  
浏览/下载:10/0
  |  
提交时间:2023/10/17
Rucaparib cocrystal: Improved solubility and bioavailability over camsylate
期刊论文
OAI收割
INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2023, 卷号: 631, 页码: 10
作者:
Xia, Mengyuan
;
Jiang, Yihua
;
Cheng, Yinxiang
;
Dai, Wenjuan
;
Rong, Xiaoyi
  |  
收藏
  |  
浏览/下载:63/0
  |  
提交时间:2023/04/10
Rucaparib
Cocrystal
Solubility
Dissolution
Bioavailability
Thioparib inhibits homologous recombination repair, activates the type I IFN response, and overcomes olaparib resistance
期刊论文
OAI收割
EMBO MOLECULAR MEDICINE, 2023, 页码: 24
作者:
Wang, Li-Min
;
Wang, Pingyuan
;
Chen, Xiao-Min
;
Yang, Hui
;
Song, Shan-Shan
  |  
收藏
  |  
浏览/下载:21/0
  |  
提交时间:2023/04/10
homologous recombination repair
olaparib-resistant
PARP inhibitor
PARP7
type I interferons
Bioinformatics analysis and in vivo validation study of Ophiocordyceps sinensis (Berk.)GHSungetal against lung adenocarcinoma
期刊论文
OAI收割
JOURNAL OF ETHNOPHARMACOLOGY, 2023, 卷号: 317
作者:
Zhang, Xingfang
;
Wang, Mengyuan
;
Liang, Xinxin
;
Wang, Jianv
;
Zhang, Ming
  |  
收藏
  |  
浏览/下载:4/0
  |  
提交时间:2023/12/01
Design, synthesis and pharmacological evaluation of new PARP1 inhibitors by merging pharmacophores of olaparib and the natural product alantolactone
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2022, 卷号: 240, 页码: 114574
作者:
Kayumov, Muzaffar
;
Jia, Li
;
Pardaev, Azizbek
;
Song, Shan-Shan
;
Mirzaakhmedov, Sharafitdin
  |  
收藏
  |  
浏览/下载:12/0
  |  
提交时间:2024/03/21
PARP1
Olaparib
Alantolactone
Syntheticlethality
BRCA1/2mutant
Fuzuloparib Maintenance Therapy in Patients With Platinum-Sensitive, Recurrent Ovarian Carcinoma (FZOCUS-2): A Multicenter, Randomized, Double-Blind, Placebo-Controlled, Phase III Trial
期刊论文
OAI收割
JOURNAL OF CLINICAL ONCOLOGY, 2022, 卷号: 40
作者:
Li, Ning
;
Zhang, Youzhong
;
Wang, Jing
;
Zhu, Jianqing
;
Wang, Li
  |  
收藏
  |  
浏览/下载:26/0
  |  
提交时间:2022/12/22
BRCANet: A deep hybrid network in predicting BRCA1/2 gene mutation of breast cancer with dynamic contrast-enhanced breast MRI.
期刊论文
OAI收割
JOURNAL OF CLINICAL ONCOLOGY, 2022, 卷号: 40
作者:
Cao, Wen-Ming
;
Wang, Xiaojia
;
Liu, Jian
;
Wang, Lili
;
Zhang, Xiaodong
  |  
收藏
  |  
浏览/下载:27/0
  |  
提交时间:2022/12/23
Bioinformatics Screening of Potential Biomarkers from mRNA Expression Profiles to Discover Drug Targets and Agents for Cervical Cancer
期刊论文
OAI收割
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2022, 卷号: 23, 期号: 7, 页码: 21
作者:
Reza, Md Selim
;
Harun-Or-Roshid, Md
;
Islam, Md Ariful
;
Hossen, Md Alim
;
Hossain, Md Tofazzal
  |  
收藏
  |  
浏览/下载:17/0
  |  
提交时间:2022/12/07
cervical cancer
mRNA expression profiles
key genes
candidate drugs
integrated bioinformatics analysis