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Chinese Academy of Sciences Institutional Repositories Grid
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上海药物研究所 [30]
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期刊论文 [87]
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Development of a novel
18
F-labeled small molecule probe for PET imaging of mesenchymal epithelial transition receptor expression
期刊论文
OAI收割
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, 2023, 页码: 13
作者:
Bu, Lihong
;
Ma, Xiaowei
;
Ji, Aiyan
;
Geng, Kaijun
;
Feng, Hongyan
  |  
收藏
  |  
浏览/下载:7/0
  |  
提交时间:2023/12/19
Mesenchymal epithelial transition receptor
Gliomas
[18F]-AZC
PET
Quinoline derivative compound
Design, synthesis, and biological evaluation of novel spirocyclic compounds as potential anti-glioblastoma agents
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2023, 卷号: 258, 页码: 22
作者:
Zhu, Heping
;
Song, Xiaomin
;
Pan, Yihui
;
Li, Ming
;
Chen, Liang
  |  
收藏
  |  
浏览/下载:11/0
  |  
提交时间:2023/10/17
Glioblastoma
Spirocyclic compounds
Drug design
Antiproliferation
LogD7.4 prediction enhanced by transferring knowledge from chromatographic retention time, microscopic pKa and logP
期刊论文
OAI收割
JOURNAL OF CHEMINFORMATICS, 2023, 卷号: 15, 期号: 1, 页码: 13
作者:
Wang, Yitian
;
Xiong, Jiacheng
;
Xiao, Fu
;
Zhang, Wei
;
Cheng, Kaiyang
  |  
收藏
  |  
浏览/下载:13/0
  |  
提交时间:2023/10/17
logD7.4
Lipid solubility
Graph neural network
Molecular property prediction
Preferred microenvironments of halogen bonds and hydrogen bonds revealed using statistics and QM/MM calculation studies
期刊论文
OAI收割
PHYSICAL CHEMISTRY CHEMICAL PHYSICS, 2023, 卷号: 25, 期号: 26, 页码: 17692-17699
作者:
Zhou, Liping
;
Li, Jintian
;
Shi, Yulong
;
Wu, Leyun
;
Zhu, Weiliang
  |  
收藏
  |  
浏览/下载:21/0
  |  
提交时间:2023/10/17
Discovery of orally effective and safe GPR40 agonists by incorporating a chiral, rigid and polar sulfoxide into 8-position to the carboxylic acid
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2023, 卷号: 251, 页码: 115267
作者:
Chen, Cheng
;
Guo, Shi-Meng
;
Sun, Yuanjun
;
Li, He
;
Hu, Nan
  |  
收藏
  |  
浏览/下载:1/0
  |  
提交时间:2024/03/27
GPR40
Glucose-stimulated insulin secretion
Type 2 diabetes mellitus
Lipophilicity
Liver safety
Three-in-one pharmacophore
2-(phenylsulfinyl)acetic acid
Unsymmetrical Phosphodiesters as GPR84 Antagonists with High Blood Exposure for the Treatment of Lung Inflammation
期刊论文
OAI收割
JOURNAL OF MEDICINAL CHEMISTRY, 2023, 卷号: 66, 期号: 8, 页码: 5820-5838
作者:
Li, Shao-Xian
;
Wang, Si-Wei
;
Chen, Lin-Hai
;
Zhang, Qing
;
Lu, Dan
  |  
收藏
  |  
浏览/下载:3/0
  |  
提交时间:2024/03/27
Design, synthesis and biological evaluation of 4-aminoquinoline derivatives as receptor-interacting protein kinase 2 (RIPK2) inhibitors
期刊论文
OAI收割
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, 2023, 卷号: 38, 期号: 1, 页码: 282-293
作者:
Fan, Tiantian
;
Ji, Yinchun
;
Chen, Danqi
;
Peng, Xia
;
Ai, Jing
  |  
收藏
  |  
浏览/下载:14/0
  |  
提交时间:2023/04/10
RIPK2 inhibitor
NOD
immunity
inflammation
Structural basis for molecular recognition of G protein-coupled estrogen receptor by selected bisphenols
期刊论文
OAI收割
SCIENCE OF THE TOTAL ENVIRONMENT, 2021, 卷号: 793, 页码: -
作者:
Liu, Xiuchang
;
Xue, Qiao
;
Zhang, Huazhou
;
Fu, Jianjie
;
Zhang, Aiqian
  |  
收藏
  |  
浏览/下载:8/0
  |  
提交时间:2022/01/04
Structure-dependent GPER binding
Molecular recognition mechanism
Induced-fit effect
Molecular dynamics simulations
Bisphenols
Lipophilic Conjugates of Drugs: A Tool to Improve Drug Pharmacokinetic and Therapeutic Profiles
期刊论文
OAI收割
PHARMACEUTICAL RESEARCH, 2021, 页码: 22
作者:
Han, Sifei
;
Mei, Lianghe
;
Quach, Tim
;
Porter, Chris
;
Trevaskis, Natalie
  |  
收藏
  |  
浏览/下载:46/0
  |  
提交时间:2021/11/04
conjugate
lipid
lymphatic
pharmacokinetics
prodrug
Anisotropic Rock Poroelasticity Evolution in Ultra-low Permeability Sandstones under Pore Pressure, Confining Pressure, and Temperature: Experiments with Biot's Coefficient
期刊论文
OAI收割
ACTA GEOLOGICA SINICA-ENGLISH EDITION, 2021, 卷号: 95, 期号: 3, 页码: 937-945
作者:
Du SH(杜书恒)
;
Du SH(杜书恒)
  |  
收藏
  |  
浏览/下载:12/0
  |  
提交时间:2021/08/16