中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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CAS IR Grid
机构
上海药物研究所 [12]
采集方式
OAI收割 [12]
内容类型
期刊论文 [12]
发表日期
2024 [1]
2023 [4]
2022 [7]
学科主题
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D3Rings: A Fast and Accurate Method for Ring System Identification and Deep Generation of Drug-Like Cyclic Compounds
期刊论文
OAI收割
JOURNAL OF CHEMICAL INFORMATION AND MODELING, 2024, 卷号: 64, 期号: 3, 页码: 724-736
作者:
Ma, Minfei
;
Zhang, Xinben
;
Zhou, Liping
;
Han, Zijian
;
Shi, Yulong
  |  
收藏
  |  
浏览/下载:18/0
  |  
提交时间:2024/03/13
Discovery of zolinium TSG1180 as a novel agonist of transgelin-2 for treating asthma
期刊论文
OAI收割
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2023, 卷号: 167, 页码: 115556
作者:
Yuan, Hong-Kai
;
Li, Bo
;
Wu, Leyun
;
Wang, Xue-Ling
;
Lv, Zhi-Ying
  |  
收藏
  |  
浏览/下载:6/0
  |  
提交时间:2024/03/26
Active learning
Consensus labelling
Eye irritation
Serious eye damage
Structural alerts
D3CARP: a comprehensive platform with multiple-conformation based docking, ligand similarity search and deep learning approaches for target prediction and virtual screening
期刊论文
OAI收割
COMPUTERS IN BIOLOGY AND MEDICINE, 2023, 卷号: 164, 页码: 8
作者:
Shi, Yulong
;
Zhang, Xinben
;
Yang, Yanqing
;
Cai, Tingting
;
Peng, Cheng
  |  
收藏
  |  
浏览/下载:21/0
  |  
提交时间:2023/10/17
Target prediction
Virtual screening
Molecular docking
Ligand similarity search
Deep learning
Preferred microenvironments of halogen bonds and hydrogen bonds revealed using statistics and QM/MM calculation studies
期刊论文
OAI收割
PHYSICAL CHEMISTRY CHEMICAL PHYSICS, 2023, 卷号: 25, 期号: 26, 页码: 17692-17699
作者:
Zhou, Liping
;
Li, Jintian
;
Shi, Yulong
;
Wu, Leyun
;
Zhu, Weiliang
  |  
收藏
  |  
浏览/下载:21/0
  |  
提交时间:2023/10/17
Molecular dynamics study on the behavior and binding mechanism of target protein Transgelin-2 with its agonist TSG12 for anti-asthma drug discovery
期刊论文
OAI收割
COMPUTERS IN BIOLOGY AND MEDICINE, 2023, 卷号: 153, 页码: 7
作者:
Wu, Leyun
;
Wang, Guangpu
;
Zhou, Liping
;
Mo, Mengxia
;
Shi, Yulong
  |  
收藏
  |  
浏览/下载:15/0
  |  
提交时间:2023/04/10
Pharmaceutical sciences
Molecular dynamics simulation
Free energy calculation
Asthma
Target protein
Transgelin-2
Agonist
Exploring the Binding Affinity and Mechanism between ACE2 and the Trimers of Delta and Omicron Spike Proteins by Molecular Dynamics Simulation and Bioassay
期刊论文
OAI收割
JOURNAL OF CHEMICAL INFORMATION AND MODELING, 2022, 页码: 11
作者:
Zhou, Liping
;
Liu, Tingting
;
Mo, Mengxia
;
Shi, Yulong
;
Wu, Leyun
  |  
收藏
  |  
浏览/下载:22/0
  |  
提交时间:2022/11/11
Conserved protein targets for developing pan-coronavirus drugs based on sequence and 3D structure similarity analyses
期刊论文
OAI收割
COMPUTERS IN BIOLOGY AND MEDICINE, 2022, 卷号: 145, 页码: 105455
作者:
Ma, Minfei
;
Yang, Yanqing
;
Wu, Leyun
;
Zhou, Liping
;
Shi, Yulong
  |  
收藏
  |  
浏览/下载:8/0
  |  
提交时间:2024/03/21
Pharmaceutical informatics
Drug design
Target discovery
Medicinal chemistry
Broad-spectrum drugs
D3AI-CoV: a deep learning platform for predicting drug targets and for virtual screening against COVID-19
期刊论文
OAI收割
BRIEFINGS IN BIOINFORMATICS, 2022, 页码: 16
作者:
Yang, Yanqing
;
Zhou, Deshan
;
Zhang, Xinben
;
Shi, Yulong
  |  
收藏
  |  
浏览/下载:35/0
  |  
提交时间:2022/06/15
D3AI-CoV
COVID-19
deep learning
target prediction
virtual screening
Replica Exchange Molecular Dynamics
期刊论文
OAI收割
PROGRESS IN CHEMISTRY, 2022, 卷号: 34, 期号: 2, 页码: 384-396
作者:
Peng, Cheng
;
Wu, Leyun
;
Xu, Zhijian
;
Zhu, Weiliang
  |  
收藏
  |  
浏览/下载:13/0
  |  
提交时间:2022/08/16
replica exchange molecular dynamics
variation
sampling efficiency
number of replica
conformational change
Predicting spike protein NTD mutations of SARS-CoV-2 causing immune evasion by molecular dynamics simulations
期刊论文
OAI收割
PHYSICAL CHEMISTRY CHEMICAL PHYSICS, 2022, 卷号: 24, 期号: 5, 页码: 3410-3419
作者:
Zhou, Liping
;
Wu, Leyun
;
Peng, Cheng
;
Yang, Yanqing
;
Shi, Yulong
  |  
收藏
  |  
浏览/下载:25/0
  |  
提交时间:2022/06/15